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Brimonidine Tartrate-Timolol

Brimonidine Tartrate-Timolol 5ML of 0.2-0.5%

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What is Brimonidine Tartrate-Timolol?

Brimonidine Tartrate-Timolol is a medication used to lower eye pressure in people with glaucoma or ocular hypertension. It helps prevent vision loss by reducing fluid in the eyes.

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What is Brimonidine Tartrate-Timolol ?

Brimonidine Tartrate-Timolol is a medication used to lower eye pressure in people with glaucoma or ocular hypertension. It helps prevent vision loss by reducing fluid in the eyes.

Source: MedlinePlus, U.S. National Library of Medicine

  • Chest pain or discomfort
  • Slow, fast, or uneven heartbeat
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Eye redness, pain, swelling of your eye or eyelid, sensitivity to light
  • Trouble breathing
  • Blurred vision or other changes in vision
  • Unusual tiredness or weakness
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Burning, dryness, itching, or stinging in the eyes
  • Tell your doctor if you are pregnant or breastfeeding, or if you have a blood vessel disorder, depression, diabetes, heart disease, low blood pressure, lung disease, myasthenia gravis, overactive thyroid, or a history of stroke or allergies. Tell your doctor if you have had eye surgery.
  • Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • This medicine may raise or lower your blood sugar level.
  • This medicine may make you drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Trouble breathing
  • Unusual tiredness or weakness
What is brimonidine-timolol (Combigan) used for?
It is used to lower elevated intraocular pressure (eye pressure) in people with open-angle glaucoma or ocular hypertension whose pressure is not adequately controlled on a single medicine. It combines brimonidine and timolol in one drop and is usually dosed as one drop in the affected eye or eyes twice daily, about 12 hours apart.
How long does it take for brimonidine-timolol eye drops to lower eye pressure?
The drops begin lowering eye pressure within hours of dosing, but your eye doctor measures the true effect over the following days and weeks and may adjust your treatment. Keep using the drops exactly as prescribed and attend your follow-up pressure checks, even if your eyes feel normal, since high eye pressure usually has no symptoms.
What are the most common side effects of brimonidine-timolol eye drops?
Common effects include eye redness, burning or stinging, and eye itching or irritation. The brimonidine component can also cause drowsiness or fatigue and may lower blood pressure. Because the timolol component is absorbed into the body, tell your doctor promptly about any trouble breathing, wheezing, slow or irregular heartbeat, or unusual dizziness.
Can you use brimonidine-timolol if you have asthma or COPD?
No. Brimonidine-timolol is contraindicated in people with bronchial asthma or a history of asthma and in severe COPD, because the timolol (beta-blocker) component is absorbed systemically and can trigger serious bronchospasm. If you have any breathing condition, tell your eye doctor so they can choose a safer pressure-lowering drop for you.
Is there a generic version of Combigan?
Yes. Brimonidine tartrate / timolol maleate ophthalmic solution is the FDA-approved generic equivalent of Combigan and is widely available. The generic is generally much less expensive than the brand, though the cash price varies by pharmacy, so enter your ZIP above to compare prices and get a free Rx.com coupon.
How much does Brimonidine Tartrate-Timolol cost without insurance?
The price of Brimonidine Tartrate-Timolol without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Brimonidine Tartrate-Timolol?
Common side effects of Brimonidine Tartrate-Timolol may include: Chest pain or discomfort, Slow, fast, or uneven heartbeat, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Eye redness, pain, swelling of your eye or eyelid, sensitivity to light, Trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Brimonidine Tartrate-Timolol?
Generic versions may be available for Brimonidine Tartrate-Timolol. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Brimonidine Tartrate-Timolol on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Brimonidine Tartrate-Timolol?
The cheapest pharmacy for Brimonidine Tartrate-Timolol depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Brimonidine Tartrate-Timolol near you.

Brimonidine Tartrate-Timolol Coupons & Prices

Brimonidine Tartrate-Timolol 5ML of 0.2-0.5%

Prescriptions & Refills
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Looking for a brimonidine-tartrate-timolol coupon? Brimonidine tartrate / timolol maleate ophthalmic solution is the generic form of Combigan, a twice-daily eye drop that lowers elevated eye pressure in open-angle glaucoma or ocular hypertension. Because it is a generic, it is already one of the lower-cost ways to treat high eye pressure, but the cash price still varies widely from one pharmacy to the next. Enter your ZIP above to see today's price and compare a free Rx.com discount across more than 60,000 pharmacies near you.

What is brimonidine-timolol and how does it work?

Brimonidine tartrate / timolol maleate is a combination eye drop that pairs two pressure-lowering medicines in a single bottle. Brimonidine is an alpha-2 adrenergic agonist and timolol is a non-selective beta-adrenergic blocker. Together they reduce the amount of fluid the eye makes and help fluid drain, which lowers intraocular pressure (IOP). It is the generic equivalent of the brand Combigan.

It is prescribed for people with open-angle glaucoma or ocular hypertension whose eye pressure is not controlled well enough on a single medicine, either as add-on (adjunctive) therapy or as a replacement. The usual dose is one drop in the affected eye or eyes twice a day, roughly 12 hours apart. Always follow the exact directions from your eye doctor.

Cost of generic brimonidine-timolol without insurance

Generic brimonidine-timolol is widely available and substitutable for Combigan, so it is generally far less expensive than the brand. Even so, the cash price without insurance can differ a lot depending on which pharmacy you use, so it pays to compare before you fill. Rx.com checks discounted prices across more than 60,000 pharmacies so you can find a lower price near you. Enter your ZIP above to see today's price and print or text yourself a free coupon.

If your prescriber wants you on the brand, the maker of Combigan (AbbVie) runs an official manufacturer savings program on the Combigan website; eligibility and terms vary and it typically cannot be combined with a discount coupon. For most people, comparing cash prices on the generic with a free Rx.com coupon is the simplest way to keep costs down.

Alternatives and related eye-pressure drops

Brimonidine-timolol is one of several options for lowering eye pressure, and your doctor chooses based on how well your pressure is controlled and how you tolerate each drop. Related medicines you may want to compare include:

  • Combigan - the brand-name version of this same brimonidine-timolol combination.
  • Brimonidine - the alpha-2 agonist component used on its own.
  • Timolol - the beta-blocker component used on its own.
  • Dorzolamide-timolol - another twice-daily combination eye drop that pairs a beta-blocker with a carbonic anhydrase inhibitor.
  • Latanoprost - a once-daily prostaglandin drop often used as a first-line option.

Do not switch or stop drops on your own. Ask your eye doctor which option fits your pressure targets and health history, then compare prices here.

Safety, contraindications, and who should not use it

Brimonidine-timolol has no FDA boxed warning, but the timolol (beta-blocker) part is absorbed into the bloodstream and carries real cautions. It is contraindicated in people with reactive airway disease such as bronchial asthma or a history of asthma, severe COPD, sinus bradycardia, second- or third-degree AV block, overt heart failure, or cardiogenic shock. Because the beta-blocker can reach the rest of the body, it may cause serious breathing reactions (bronchospasm) and serious heart reactions, and it can mask the warning signs of low blood sugar and of an overactive thyroid.

The brimonidine part can cause drowsiness, fatigue, and lower blood pressure. This medicine is not for newborns or infants under 2 years old because of the risk of apnea and central nervous system depression, and it should be used with caution in older children. Tell your doctor about all your health conditions and medicines. This is general information, not medical advice, so talk with your provider or pharmacist about what is right for you.

Sources & accuracy

This Brimonidine Tartrate-Timolol information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Brimonidine Tartrate-Timolol on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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