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Vial of compounded semaglutide
Illustrative image

Compounded · weekly GLP-1 injection

Compounded Semaglutide, prescribed online and shipped to your door

$99 $175 /mo · 12-month plan Save $912

$1,188 total. Same price at every dose.

Continue to checkout Nothing charged until a provider approves you
  • No auto-renew. Refills ship only when you confirm.
  • One price at every dose. 0.25 mg to 2.4 mg, no step-up charges.
  • Everything included. Provider visit, supplies and cold-packed shipping.
Verify LegitScript Approval for www.rx.com

LegitScript certified. Licensed U.S. providers and a licensed U.S. compounding pharmacy, available in 49 states. Provider review usually within 24 hours.

Pricing

Your dose goes up. Your price doesn't.

Semaglutide is usually stepped up about every 4 weeks. Programs that price by the milligram get more expensive at each step. Ours stays flat from the first dose to the last.

What's included

One price covers all of it

Provider visit
Included, plus ongoing check-ins
Medication
Compounded semaglutide, 0.25 mg to 2.4 mg
Supplies
Syringes, alcohol pads, dosing guide
Shipping
Cold-packed and discreet, no charge
Care team
Unlimited messaging
Membership or visit fees
None
Renewal
Never automatic

This is a compounded medication and is not FDA-approved. Its safety and effectiveness have not been verified by the FDA. Compounded medications are prepared by licensed compounding pharmacies under Section 503A of the Federal Food, Drug, and Cosmetic Act, based on a valid patient-specific prescription from a licensed healthcare provider. Rx.com does not manufacture compounded medications.

How it works

From checkout to your door

  1. Today
    2 min

    Choose a plan and check out

    Nothing is charged until a provider approves you.

  2. Within
    24 hrs

    Complete your online visit

    A confidential health questionnaire and a photo ID. A licensed provider in your state reviews it, usually within 24 hours. Some states require a short video visit.

  3. After
    approval

    Your medication ships

    A licensed U.S. compounding pharmacy prepares your prescription and ships it cold-packed with syringes, alcohol pads and a dosing guide.

Cost

How much does compounded semaglutide cost?

Compounded semaglutide through Rx.com is $99 a month on the 12-month plan, or $175 month to month. That price covers your online provider visit, the medication, supplies and cold-packed shipping, and it stays the same when your dose goes up.

Price by plan

PlanTotalPer month
12 months$1,188$99
6 months$875$145.83
3 months$495$165
Month to month$175$175

Price at every dose

Weekly doseMedication per month (about)Your price per month
0.25 mg1.1 mg$99
0.5 mg2.2 mg$99
1 mg4.3 mg$99
1.7 mg7.4 mg$99
2.4 mg10.4 mg$99

Per-month amounts are the weekly dose × 52 weeks ÷ 12 months. Price shown is the 12-month plan. Your provider decides your starting dose and when to step up.

Semaglutide is started at 0.25 mg once a week and usually stepped up about every 4 weeks. At 2.4 mg you use roughly 10 times as much medication each month as at the starting dose, so a price quoted per milligram or per vial keeps rising as you titrate. With one flat price, stepping up never changes your bill.

Before you prepay for any semaglutide plan, ask

  • Does the price change when my dose goes up? Per-milligram pricing gets more expensive every few weeks.
  • Is the provider visit included? Some programs add an intake fee or a monthly membership.
  • Are supplies and cold shipping included? Syringes, alcohol pads and cold-packed delivery can be billed separately.
  • How much ships at once? An opened multi-dose vial has a beyond-use date, so a large shipment only saves money if you can use it in time.
Compare

Semaglutide or tirzepatide?

CompareSemaglutideTirzepatide
Works onGLP-1GLP-1 + GIP
TakenOnce a weekOnce a week
Dose range0.25 mg to 2.4 mg2.5 mg to 15 mg
From$99/mo$149/mo

Both are once-weekly injections. Your provider recommends the one that fits your health history. See compounded tirzepatide →

How it works in the body

How semaglutide works

Semaglutide is a GLP-1 receptor agonist. Taken once a week, it works with your body's own appetite and blood-sugar signals.

  • Feel full soonerIt slows how quickly food leaves your stomach, so meals keep you satisfied longer and portions naturally shrink.
  • Quiet the cravingsIt acts on appetite centers in the brain, turning down hunger and the constant pull toward snacking.
  • Steadier blood sugarIt helps your body release insulin when blood sugar rises, which supports more stable energy through the day.

In the 68-week STEP 1 trial of FDA-approved semaglutide 2.4 mg (Wegovy), adults lost an average of about 15% of their body weight alongside diet and exercise. Individual results vary, and compounded semaglutide has not been studied in those trials. Semaglutide works best alongside a reduced-calorie diet and regular activity.

The basics

What is compounded semaglutide?

What compounded semaglutide is

Compounded semaglutide is semaglutide prepared by a licensed compounding pharmacy for one patient, from a prescription written by that patient's provider. It contains the same active ingredient studied in the clinical trials, but the finished product is made by the pharmacy rather than a drug manufacturer, so it has not been reviewed by the FDA for safety, effectiveness or quality. Rx.com prescribes it as a weekly injection, not a pill or drops.

Is compounded semaglutide legal?

Yes, when it is prescribed for you. The FDA declared the semaglutide shortage over in February 2025. State-licensed 503A pharmacies may still compound it for an individual patient with a valid prescription when the prescriber decides a compounded version meets that patient's medical need. The FDA has warned about products sold without a prescription, products labeled “for research use only” and products that are not made by a licensed pharmacy.

Is compounded semaglutide safe?

The active ingredient has a known safety profile, with the same boxed warning and side effects described below. The added risks with any compounded medication come from how it is made and used: the FDA has received reports of dosing mistakes when people confused milligrams, milliliters and syringe markings, and it has warned about versions made with salt forms of the drug, which are different active ingredients. That is why your prescription, your pharmacy label and the syringe your pharmacy sends matter.

How to tell a legitimate source

A prescription from a licensed provider after a medical review. A pharmacy licensed in your state that you can look up on your state board of pharmacy website. A label with the drug, strength and pharmacy name. Cold-packed shipping and a dosing guide. Walk away from anything sold without a prescription, labeled for research only, or shipped from outside the U.S.

Is compounded semaglutide legal?

Yes, when it is prescribed for you. State-licensed 503A compounding pharmacies may prepare semaglutide for an individual patient with a valid prescription when the prescriber decides a compounded version meets that patient's medical need. It is not FDA-approved.

Is compounded semaglutide safe?

The active ingredient has a known safety profile, but compounded products are not reviewed by the FDA for quality. The main added risks are dosing mistakes and poorly made products, so use a licensed provider and a state-licensed pharmacy, and follow your label and the syringe your pharmacy sends.

Is compounded semaglutide the same as the FDA-approved product?

It contains the same active ingredient, but it is not FDA-approved and is not the same as any brand-name medication. It is prepared by a compounding pharmacy for you rather than mass-produced by a manufacturer.

Read the full compounded semaglutide guide: how it is made, legal status and safety →

Important safety information

Boxed warning: Semaglutide caused thyroid C-cell tumors in rodent studies. It is not known whether it causes thyroid tumors, including medullary thyroid carcinoma, in people. Do not use semaglutide if you or any of your family have had medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2.

Common side effects include nausea, vomiting, diarrhea, constipation, stomach pain and decreased appetite, most often while your dose is being increased. Serious risks include pancreatitis, gallbladder disease, low blood sugar (especially with insulin or sulfonylureas), kidney injury from dehydration, and severe allergic reactions. Stop and seek care right away for severe stomach pain, a lump in your neck, trouble swallowing or breathing, or signs of an allergic reaction.

Do not use if you are pregnant, breastfeeding or planning pregnancy, or under 18. Tell your provider about every medication and condition during your visit. This is not a complete list of risks; your provider and the pharmacy will give you full medication information.

Questions

Frequently asked questions

What is compounded semaglutide?
Semaglutide is a GLP-1 receptor agonist that mimics a gut hormone to reduce appetite, slow stomach emptying and help control blood sugar. Compounded semaglutide is prepared for you by a licensed U.S. compounding pharmacy from a prescription written by your provider. It is not an FDA-approved product and is not the same as any brand-name medication.
How does the online visit work?
After checkout you complete a confidential medical questionnaire. A licensed provider in your state reviews it, follows up if they need more information, and decides whether semaglutide is appropriate for you. Some states require a brief video or live-chat visit. If you are not approved, you are not charged for medication.
What dose will I start on?
Most people start at 0.25 mg once a week for four weeks and step up from there as tolerated. Your provider sets your starting dose and your step-up schedule.
Does the price go up when my dose increases?
No. We do not charge by strength. Every dose costs the same, so when your provider steps you up your plan price stays exactly where it started. The only thing that changes your price is the plan length you choose.
What does the price include?
One price covers the provider visit, your medication at any prescribed dose for the plan length you choose, injection supplies and cold-packed shipping. There are no visit fees, membership fees, dose upcharges or shipping charges added at checkout.
Do I need insurance?
No. This is a cash-pay program and we do not bill insurance. You can pay with a debit or credit card, and many HSA and FSA cards are accepted.
How do I take semaglutide?
Semaglutide is injected once a week under the skin of the stomach, thigh or upper arm using a small insulin-style syringe. Your shipment includes a dosing guide and your care team can walk you through your first injection by message.
What are the side effects?
The most common side effects are nausea, vomiting, diarrhea, constipation and stomach pain, most often while your dose is being increased. Less common but serious risks include pancreatitis, gallbladder problems, low blood sugar (especially with other diabetes medicines) and kidney problems from dehydration. Semaglutide carries a boxed warning for thyroid C-cell tumors seen in rodent studies; do not use it if you or a family member has had medullary thyroid carcinoma or MEN 2.
Who should not take semaglutide?
Do not take semaglutide if you are pregnant, breastfeeding or planning pregnancy, have a personal or family history of medullary thyroid carcinoma or MEN 2, have had pancreatitis, or are under 18. Tell your provider about every medication and condition during your visit.
How do refills and cancellation work?
Your plan does not renew automatically. Before each refill your care team checks in with you, and nothing ships or is charged until you confirm. You can pause or cancel from your account at any time with no fees. Federal and state law do not allow medication to be returned once shipped, so all medication sales are final.
Where is this available?
We currently serve 49 states (all except Alaska). Some states have additional visit requirements, which are handled during intake.
Articles & guides

Semaglutide articles & guides

Independent, provider-reviewed reading on dosing, side effects, cost and what to expect, written by our editorial team.

GLP-1 Diet Plan: What to Eat on Tirzepatide or Semaglutide (7-Day Sample Menu) Eating smaller, protein-rich meals and staying hydrated can cut nausea and boost weight loss on tirzepatide or semaglutide. This guide breaks down dai... How to Get Zepbound Covered by Insurance: Prior Authorization and Appeal Steps Struggling to get your Zepbound prescription approved? This guide explains exactly how health plans decide coverage, what paperwork your doctor must s... Does Anthem Cover Zepbound? What Anthem Plans Require in 2026 Anthem’s coverage for the weight-loss shot Zepbound is plan-specific. This guide explains how to read your Anthem drug list, the BMI and documentation... Does Tirzepatide Burn Fat or Just Reduce Appetite? Does tirzepatide melt fat or only suppress appetite? We explain its dual GIP/GLP-1 mechanism, share DXA scan data on fat-versus-muscle loss, and give... Zepbound KwikPen: How the Multi-Dose Pen Works, Doses and Self-Pay Price The Zepbound KwikPen is a four-dose, single-patient-use pen that lets adults self-inject tirzepatide for weight management once a week. Learn how it d... Medicare GLP-1 Bridge Program: Who Qualifies for $50 Wegovy or Zepbound and How to Enroll The Medicare GLP-1 Bridge is a limited pilot that lets eligible beneficiaries fill Wegovy or Zepbound for a flat $50 through December 31 2027. This gu... Microdosing GLP-1s: What It Means and What the Evidence Says Microdosing a GLP-1 usually means taking less than the labeled dose of semaglutide or tirzepatide. No clinical trial has tested it; here is what is kn... What Size Needle Do You Need for Semaglutide or Tirzepatide? Gauge and length explained, why the syringe your pharmacy sends matters, comfort tips, and how to throw needles away safely. How Many Units Is 2 mg of Semaglutide? Why Your Label Has the Answer Units on a syringe measure liquid, not drug, and compounded semaglutide comes in different strengths. Why your label, not a chart, has the answer. Spoiled Ozempic or Zepbound in Transit? Replacement Rules, Fees and Shipping Insurance Explained Worried your Ozempic or Zepbound pens will arrive warm? This guide explains temperature-controlled shipping, replacement rules, optional insurance fee... Costco Pharmacy Ozempic, Wegovy, Zepbound & Rybelsus Prices for 2026 Costco’s new Member Value Pricing slashes cash prices on GLP-1 drugs. This guide shows the exact 2026 costs for every dose of Ozempic, Wegovy, Zepboun... My GLP-1 Telehealth Provider Shut Down: What to Do Next If your online clinic for semaglutide or tirzepatide just went dark, don’t panic. This step-by-step guide shows how to get your chart, move your presc... Switching GLP-1 Providers at a High Dose: How to Keep Your Current Dose Already at a high weekly dose of semaglutide or tirzepatide? This guide shows you exactly how to switch doctors or telehealth platforms while keeping... Compounded Semaglutide Monthly Cost: Visit, Medication & Shipping Included Wondering what you will actually pay each month for compounded semaglutide? This deep-dive breaks down every line item-provider visit, pharmacy dispen... Belly Fat and Low Testosterone: Can GLP-1 Weight Loss Help? Stubborn belly fat can suppress testosterone, leaving many men tired and foggy. This guide explains the biology, the exact numbers behind how much wei... How Much Weight Can You Lose on Compounded Semaglutide in 6 Months? Wondering how many pounds you can realistically drop on compounded semaglutide in half a year? This evidence-packed guide reviews the latest real-worl... Semaglutide for Women: Weight-Loss Results, Safe Dosing and What It Costs in 2026 Women lose roughly 15 % of their body weight on average with once-weekly semaglutide. This guide explains female-specific results, dosing, side effect... Can You Get a GLP-1 Prescription Online Without Lab Tests? Wondering if you can start a GLP-1 weight-loss shot like semaglutide or tirzepatide through telehealth without getting blood work first? This evidence... What’s Included in an Online GLP-1 Program: Provider Visit, Medication, Supplies and Ongoing Support Thinking about starting a virtual semaglutide or tirzepatide plan? This guide breaks down every element of a reputable online GLP-1 program-medical vi... GLP-1 for Menopause Weight Gain: How to Get Treatment Online Estrogen decline after age 45 makes it easier to gain mid-section weight and harder to lose it. Clinical trials show GLP-1 medicines such as semagluti... Which States Can You Get Compounded GLP-1s Shipped To in 2026? Wondering if a pharmacy can legally ship compounded semaglutide or tirzepatide to your door? This 2026 state-by-state guide explains where it’s allowe... Restarting Semaglutide After a Break: Dose, Cost and How to Get a New Prescription Stopped taking semaglutide and want to get back on track? This step-by-step guide explains when you must retitrate to a lower dose, how much you’ll pa... Semaglutide vs Tirzepatide Cost Per Pound Lost: A Value Breakdown We divided the annual out-of-pocket cost of Wegovy and Zepbound by the average pounds lost in landmark trials. The result: brand semaglutide costs abo... Best GLP-1 Weight Loss Medication for Men: Semaglutide vs Tirzepatide Trying to decide between semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound) for weight loss? This doctor-reviewed guide compares how muc... Who Qualifies for GLP-1 Weight-Loss Medication at BMI 27 With One Health Condition? Do you have a BMI of 27 plus high blood pressure, diabetes, or sleep apnea? You may already meet the FDA’s threshold for prescription GLP-1 weight-los... Compounded Semaglutide: What It Is, Safety, Legal Status and Cost in 2026 Compounded semaglutide is a pharmacy-made version of the GLP-1 medicine semaglutide. It is not FDA-approved. Here is how it is regulated in 2026, the... Semaglutide Titration Cost Guide 2026: How Much You’ll Spend From 0.25 mg to 1 mg and Beyond Ready to move from 0.25 mg up the semaglutide ladder? This guide lists the real 2026 prices for every dose, shows which format is cheapest and maps th... 12-Month GLP-1 Cost Calculator 2026: What a Full Year of Ozempic, Wegovy or Zepbound Really Costs Planning a full year of GLP-1 therapy? This guide breaks down every dollar (drug, telehealth, needles and labs) and lets you add it up instantly with... GLP-1 Injection Supplies in 2026: Exact Prices for Syringes, Alcohol Swabs, Bacteriostatic Water & Sharps Disposal How much do Ozempic® and semaglutide users really pay for syringes, pen needles, alcohol swabs, bacteriostatic water and sharps disposal? This 2026 gu... Compounded Oral Semaglutide in 2026: Does It Work, Is It Legal, and How Much Does It Cost? Thinking about cheaper oral semaglutide pills you saw on TikTok? This guide explains how compounded capsules are made, the 2026 FDA rules, real prices... Semaglutide Maintenance Dose After You Reach Your Goal Weight Reached your goal weight with semaglutide? Discover why most people stay on the full 2.4 mg weekly dose, what happens if you taper, real-world cost es... What Is Food Noise, and How Do You Quiet It? Food noise is the relentless mental chatter about what, when, or how much to eat. This guide unpacks the brain and hormone science behind it, why GLP-... Ozempic vs Wegovy: Same Drug, So What Is the Difference? Ozempic and Wegovy contain the same active ingredient, semaglutide, yet they are not interchangeable at the pharmacy counter. This guide breaks down t... How Much Fiber Should You Eat on a GLP-1? Constipation is the #1 digestive complaint on GLP-1 medications. This evidence-based guide shows exactly how many grams of fiber you need each day, wh... Can You Take Your Zepbound or Semaglutide Shot a Day Early? Need to move your weekly Zepbound or Ozempic injection for a holiday or trip? The FDA labels allow it-as long as doses stay 72 hours apart. This guide... How Long Does a GLP-1 Stay in Your System? Wondering how long a once-weekly GLP-1 medicine like Ozempic or Mounjaro stays in your body? Their long half-lives mean they can linger for a month af... I Took Expired Semaglutide or Tirzepatide - What Now? Worried after using an outdated GLP-1 pen or vial? This guide explains how semaglutide and tirzepatide break down, whether the dose will still work, a... Why Electrolytes Matter on a GLP-1 (and Which Ones You Actually Need) Using a GLP-1 drug can curb appetite and cause GI side effects that quietly drain electrolytes. This guide breaks down how much sodium, potassium and... Is Ozempic Made From Lizard Venom? The Gila Monster Story, Explained Viral videos claim Ozempic is “lizard spit.” This guide debunks the myth, traces the Gila-monster discovery that led to exenatide, and explains why mo... Do GLP-1 Patches Work? What to Know Before You Buy One Are “semaglutide” or “tirzepatide” skin patches legit? This expert guide explains why GLP-1 peptides cannot be absorbed through intact skin, what thos... How to Get Rid of Sulfur Burps on GLP-1 Drugs (Ozempic, Wegovy, Mounjaro) Sulfur burps are a surprisingly common, embarrassing side effect of GLP-1 weight-loss injections. Learn why they happen and science-backed ways to sto... How Long Ozempic (Semaglutide) Can Safely Sit Out of the Fridge Worried your Ozempic pen got too warm during travel or a power outage? This in-depth guide gives the precise room-temperature limits for every major G... Ozempic Weight-Loss Journey: What It’s Really Like to Drop 25 Pounds on Semaglutide Wondering if Ozempic can really take 25 lbs off the scale? We break down a Reddit user’s journey plus clinical data, side-effect hacks, dosing, and pr... Semaglutide Groupon Deals: Are They Safe and Do They Really Save Money? Groupon ads for bargain semaglutide look tempting, but most come from unregulated compounders that may ship the wrong drug, dose, or even a salt form... Semaglutide Price in 2026: Brand vs Compounded Cost Breakdown What semaglutide costs in 2026: brand list prices, NovoCare self-pay ($349/month for most doses), insurance savings cards, the $50 Medicare GLP-1 Brid... 4-Month Compounded Semaglutide Results: Weight-Loss Timeline, Side Effects and Price Most adults shed 11–15 % of their starting weight in the first four months of compounded semaglutide. Learn the dosing schedule, real-world results, a... Switching from Semaglutide to Tirzepatide: Dose, Timing & Cost Guide Thinking about moving from semaglutide to tirzepatide? This doctor-reviewed guide explains when a switch makes sense, how to line up your doses, what... Semaglutide vs Tirzepatide: Weight Loss, Side Effects and Cost Compared Tirzepatide produced more weight loss on average than semaglutide in the SURMOUNT-5 head-to-head trial, but it usually costs more. Here is how the two... How to Lose 30 Pounds in 3 Months: The Complete 12-Week, Doctor-Backed Plan A realistic, science-based roadmap for dropping 30 pounds in just 12 weeks—without crash dieting. Learn exactly how many calories to cut, which workou... Semaglutide Dosage Chart for Weight Loss: Doses by Week Week-by-week semaglutide dosing from the FDA labels: the Wegovy shot steps from 0.25 mg to 2.4 mg over 16 weeks (up to 7.2 mg for some adults), and th... Semaglutide (Ozempic) Side Effects: What’s Normal and What’s Not Semaglutide (Ozempic, Wegovy) can cause nausea, constipation, gallstones and more. This guide breaks down real clinical numbers, red-flag symptoms and... Creatine for Weight Loss: Does It Help or Hurt Your Fat-Loss Goals? Wondering if creatine can help—or hurt—your weight-loss progress? This guide separates science from myths, explains who benefits, and shows how to use... GLP-1 Weight-Loss Medications: How They Work, How Much Weight You Can Lose, and How to Get Started GLP-1 medications are changing obesity care. This in-depth guide explains exactly how they work, typical weight-loss averages, dosing schedules, real-... How to Switch GLP-1 Telehealth Providers Without Losing Your Dose Worried you’ll have to start over if you move your GLP-1 prescription to a new virtual clinic? This step-by-step guide explains how to switch teleheal... 9 Things I Wish I Knew Before Starting GLP-1 Weight-Loss Injections New to GLP-1 weight-loss shots? This in-depth guide distills the nine lessons real patients wish they knew before their first injection—from dosing sc... GLP-1 Survival Guide for New Ozempic, Wegovy, and Mounjaro Users Starting Ozempic, Wegovy, or Mounjaro? This step-by-step survival guide covers dosing, side-effect hacks, red-flag symptoms, and where to get GLP-1 pr... A 6-Week Semaglutide Plan: Realistic Results What to actually expect in your first 6 weeks on a semaglutide GLP-1 — week by week. Compounded GLP-1s: How They Work, Legality & Cost How compounded semaglutide and tirzepatide compare, what the regulatory landscape looks like, and how to find a reputable provider. Is GLP-1 the Same as Ozempic? What "GLP-1" actually means, how Ozempic fits in, and why the distinction matters for choosing a treatment. Peptides for Weight Loss How GLP-1 peptides like semaglutide compare to research peptides for weight loss — a complete guide.

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Wegovy® and Ozempic® are registered trademarks of Novo Nordisk A/S. Compounded semaglutide is not FDA-approved and is not equivalent to any brand-name medication. Information on this page is educational and is not a substitute for advice from your own healthcare provider. See our Weight Loss Program page for the full program FAQ.

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