Buprenorphine Hcl-Naloxone Hcl
Buprenorphine HCl-Naloxone HCl 30 Film
What is Buprenorphine Hcl-Naloxone Hcl?
Buprenorphine HCl-Naloxone HCl is a combination medication used primarily to treat opioid addiction by reducing withdrawal symptoms and cravings. Buprenorphine acts as a partial opioid agonist, offering pain relief and mood stabilization, while Naloxone is an opioid antagonist that blocks opioid effects, deterring misuse. This dual-action therapy is crucial for maintaining sobriety and managing dependency effectively.Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
- Blue lips, fingernails, or skin, trouble breathing
Warnings
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease (including hepatitis), lung or breathing problems (including sleep apnea), tooth problems (including history of cavities), adrenal gland problems, an enlarged prostate, trouble urinating, gallbladder problems, thyroid problems, stomach problems, or a history of depression. Tell your doctor if you have heart disease, congestive heart failure, a slow heartbeat, or a history of heart rhythm problems (including long QT syndrome). Tell your doctor if you have a brain tumor, head injury, or alcohol or drug abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Adrenal gland problemsSleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Low blood pressureLiver problemsQT prolongation (heart rhythm problem)Tooth problems (including tooth fracture, tooth loss)Serotonin syndrome, when used with certain medicines
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
Prescription savings · · · ·
What is Buprenorphine Hcl-Naloxone Hcl ?
Buprenorphine HCl-Naloxone HCl is a combination medication used primarily to treat opioid addiction by reducing withdrawal symptoms and cravings. Buprenorphine acts as a partial opioid agonist, offering pain relief and mood stabilization, while Naloxone is an opioid antagonist that blocks opioid effects, deterring misuse. This dual-action therapy is crucial for maintaining sobriety and managing dependency effectively.- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
- Blue lips, fingernails, or skin, trouble breathing
- Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Shaking, trembling, hunger
- Trouble breathing or slow breathing
- Toothache
- Fast, pounding, or uneven heartbeat
- Severe confusion, lightheadedness, dizziness, or fainting
- Extreme dizziness, drowsiness, or weakness, slow heartbeat, sweating, seizures, cold or clammy skin
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease (including hepatitis), lung or breathing problems (including sleep apnea), tooth problems (including history of cavities), adrenal gland problems, an enlarged prostate, trouble urinating, gallbladder problems, thyroid problems, stomach problems, or a history of depression. Tell your doctor if you have heart disease, congestive heart failure, a slow heartbeat, or a history of heart rhythm problems (including long QT syndrome). Tell your doctor if you have a brain tumor, head injury, or alcohol or drug abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Adrenal gland problemsSleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Low blood pressureLiver problemsQT prolongation (heart rhythm problem)Tooth problems (including tooth fracture, tooth loss)Serotonin syndrome, when used with certain medicines
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- Tell any doctor or dentist who treats you that you are using this medicine. Schedule regular dental checkups while taking this medicine.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Buprenorphine Hcl-Naloxone Hcl Coupons & Prices
Buprenorphine HCl-Naloxone HCl 30 Film
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a buprenorphine/naloxone coupon? Buprenorphine/naloxone (the generic of Suboxone) is a widely used, FDA-approved medication for the maintenance treatment of opioid use disorder. Because a substitutable generic is available, the cash price is often much lower than the brand, but what you pay can still vary widely from one pharmacy to the next. Enter your ZIP above to compare today's price across more than 60,000 pharmacies with a free Rx.com discount and see where it costs the least near you.
What is buprenorphine/naloxone and how does it work?
Buprenorphine/naloxone is a combination medicine taken under the tongue (sublingual film or tablet) as part of a complete treatment plan for opioid use disorder (OUD) in adults, alongside counseling and psychosocial support. Buprenorphine is a partial mu-opioid agonist that eases cravings and withdrawal, while naloxone is an opioid antagonist added to deter misuse. It is sold under brand names including Suboxone, Zubsolv, and Cassipa.
These sublingual products are generally used for maintenance rather than for starting (inducting) treatment in people transitioning from long-acting opioids, because the naloxone component can precipitate withdrawal if taken too soon after a full-agonist opioid. This page is educational and not a substitute for advice from your prescriber.
Cost and savings without insurance
Buprenorphine/naloxone is available as an FDA-approved generic, which is typically far less expensive than brand-name Suboxone. Even so, cash prices are not the same everywhere: the amount you pay for the same strength and quantity can differ significantly between two nearby pharmacies, which is exactly why comparing before you fill matters.
Enter your ZIP above to see today's discounted price at pharmacies near you. There is no membership fee to use an Rx.com coupon. The brand maker of Suboxone also offers a savings program on its official website (suboxone.com); eligibility and terms vary and it generally cannot be combined with a discount coupon, so it is worth checking both to see which works out lower for you.
Related medications and alternatives
Buprenorphine/naloxone is one of several medications for opioid use disorder. Your prescriber chooses among them based on your history and needs. Related options include:
- Suboxone — the brand-name version of this same buprenorphine/naloxone combination.
- Zubsolv — another sublingual buprenorphine/naloxone brand.
- Buprenorphine alone — used in certain situations, such as induction or pregnancy, where the naloxone component is not wanted.
- Methadone — a full-agonist option dispensed through certified opioid treatment programs.
- Naltrexone — an opioid antagonist used after a person is fully detoxified.
Compare prices on any of these with your ZIP code to find the lowest cash cost near you.
Safety information
Buprenorphine/naloxone can cause life-threatening respiratory depression and death, especially when combined with benzodiazepines, alcohol, or other central nervous system depressants. Tell your provider about every medication you take. It carries a risk of dependence, misuse, and diversion, and can precipitate opioid withdrawal if taken too soon after a full-agonist opioid. Do not stop it abruptly.
Other reported risks include accidental exposure in children (keep it stored safely out of reach, as it can be fatal to a child), neonatal opioid withdrawal syndrome if used in pregnancy, liver injury (your provider may monitor liver function), adrenal insufficiency, dose-related QT prolongation, and orthostatic (positional) low blood pressure. This is not a complete list. Talk with your prescriber or pharmacist about your personal risks before making any changes.
This Buprenorphine Hcl-Naloxone Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Buprenorphine Hcl-Naloxone Hcl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Related Drugs
Browse more medications: starting with B · full A-Z directory · by condition · common drugs
Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.