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Entecavir

Entecavir 0.5MG

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What is Entecavir?

Entecavir (Baraclude) is a prescription antiviral medication used to treat chronic hepatitis B virus (HBV) infection in adults and children. It helps reduce the amount of hepatitis B virus in the body, slowing liver damage and lowering the risk of serious complications such as cirrhosis and liver cancer.

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What is Entecavir ?

Entecavir (Baraclude) is a prescription antiviral medication used to treat chronic hepatitis B virus (HBV) infection in adults and children. It helps reduce the amount of hepatitis B virus in the body, slowing liver damage and lowering the risk of serious complications such as cirrhosis and liver cancer.

  • Fast breathing, trouble breathing, nausea and vomiting, lightheadedness, severe weakness, tiredness, or confusion
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or you had a liver transplant.
  • Tell your doctor if you have HIV. You may need to get an HIV test before you start taking this medicine and anytime after that if there is a chance you were exposed to HIV.
  • This medicine may cause lactic acidosis (a buildup of acid in your blood).
  • This medicine will not cure hepatitis B or prevent you from spreading hepatitis B to another person through sexual contact or contact with your blood.
What is entecavir used for?
Entecavir is used to treat chronic (long-term) hepatitis B virus infection in adults and children at least 2 years old who have evidence of active viral replication and either persistent liver enzyme (ALT) elevations or active liver disease. It lowers the amount of virus in the body to help protect the liver, but it does not cure hepatitis B.
What are the most common side effects of entecavir?
Commonly reported side effects include headache, tiredness, dizziness, and nausea. More serious but less common risks include worsening of hepatitis B if the medicine is stopped and, with this drug class, a rare buildup of lactic acid in the blood along with liver enlargement. Contact your provider if you have unusual muscle pain, severe tiredness, stomach pain, or yellowing of the skin or eyes.
Should entecavir be taken with or without food?
Entecavir should be taken on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal. Taking it with food can lower how much of the medicine your body absorbs. Try to take it at the same time each day, and follow your provider's instructions.
What happens if you stop taking entecavir?
Stopping entecavir can cause a severe, sudden flare-up (acute exacerbation) of hepatitis B, which is why it carries a boxed warning about this risk. Do not stop taking it without talking to your provider. If you do stop, your provider will monitor your liver function closely for at least several months afterward.
Is entecavir a cure for hepatitis B?
No. Entecavir controls hepatitis B by suppressing the virus and lowering the viral load, which helps reduce liver damage, but it does not cure the infection. Many people need to keep taking it long term, and your provider will decide how long treatment should continue.
How much does Entecavir 0.5MG cost without insurance?
The price of Entecavir 0.5MG without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Entecavir 0.5MG?
Common side effects of Entecavir 0.5MG may include: Fast breathing, trouble breathing, nausea and vomiting, lightheadedness, severe weakness, tiredness, or confusion, Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Entecavir 0.5MG?
Generic versions may be available for Entecavir 0.5MG. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Entecavir 0.5MG on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Entecavir 0.5MG?
The cheapest pharmacy for Entecavir 0.5MG depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Entecavir 0.5MG near you.

Entecavir Coupons & Prices

Entecavir 0.5MG

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Looking for an entecavir coupon? Entecavir is the generic version of Baraclude, a once-daily antiviral used to treat chronic hepatitis B. Because it is available as a generic, it is already one of the lower-cost hepatitis B treatments, but the cash price can still vary widely from one pharmacy to the next. Rx.com compares entecavir prices across more than 60,000 pharmacies so you can find a free discount coupon and pay the lowest cash price near you. Enter your ZIP above to see today's price.

What is entecavir and how does it work?

Entecavir is a nucleoside analogue (a guanosine analogue) antiviral used to treat long-term (chronic) infection with the hepatitis B virus (HBV) in adults and in children at least 2 years of age who have signs of active viral replication along with either ongoing liver enzyme (ALT) elevations or active liver disease. It works by interfering with the enzyme the virus needs to copy itself, which lowers the amount of virus in the body and helps reduce liver damage over time.

Entecavir is the active ingredient in the brand-name product Baraclude, and it is taken once a day by mouth. It is important to understand that entecavir controls hepatitis B by suppressing the virus; it is not a cure. This is general information, not medical advice, so talk with your provider about whether entecavir is right for you.

Entecavir cost and coupons without insurance

Entecavir is available as an FDA-approved generic, so it typically costs far less than brand-name Baraclude. Even so, the cash price for the same tablet strength can differ significantly between nearby pharmacies, which is exactly why comparing prices matters. If you are paying without insurance, a lower sticker price at one store versus another can make a real difference on a medication you take every day, long term.

Rx.com lets you compare entecavir prices across more than 60,000 U.S. pharmacies and print or show a free discount coupon at the counter. The coupon can be used whether or not you have insurance, and in some cases the discounted cash price may beat an insurance copay. Enter your ZIP above to see today's price at pharmacies near you.

Entecavir alternatives and related hepatitis B drugs

Entecavir is one of several first-line oral antivirals for chronic hepatitis B. Your provider chooses a treatment based on your kidney function, prior therapy, and other health factors. Related medications include:

  • tenofovir (tenofovir disoproxil fumarate), another commonly used first-line HBV antiviral
  • Vemlidy (tenofovir alafenamide), a newer tenofovir prodrug
  • Viread (tenofovir disoproxil fumarate), the brand form of tenofovir
  • lamivudine, an older nucleoside analogue used for HBV
  • adefovir, sometimes used when resistance to other agents develops

Do not switch or combine hepatitis B medicines on your own. Only your provider can decide which regimen fits your situation, and you can compare cash prices for these options on Rx.com.

Important safety information

Entecavir carries FDA boxed warnings. Stopping hepatitis B therapy, including entecavir, can cause severe, sudden worsening (acute exacerbations) of hepatitis B, so your provider will monitor your liver for at least several months after you stop. Lactic acidosis and severe liver enlargement with fat buildup (steatosis), including fatal cases, have been reported with this class of drugs. In addition, entecavir is not recommended for people who have both HIV and HBV unless they are also on a fully effective HIV antiretroviral regimen, because HIV resistance may develop otherwise.

Entecavir should be taken on an empty stomach, and the dose may need to be lowered if you have reduced kidney function. Do not start or stop entecavir without talking to your provider. This is a brief summary and not a complete list of risks, so review the full information with your pharmacist or doctor.

Sources & accuracy

This Entecavir information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Entecavir on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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