What is Leflunomide ?

Leflunomide is a disease-modifying antirheumatic drug (DMARD) primarily used to manage the symptoms of rheumatoid arthritis and psoriatic arthritis. It works by inhibiting the enzyme dihydroorotate dehydrogenase, which is crucial in the synthesis of pyrimidine nucleotides and thus reduces inflammation and slows the progression of the disease. Leflunomide also has immunomodulatory properties that help in reducing joint damage and improving physical function.

• Chest pain or discomfort, trouble breathing
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow eyes or skin
• Unusual bleeding, bruising, or weakness
• Fever, chills, cough, sore throat, body aches
• Blistering, peeling, or red skin rash
• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Numbness, tingling, or burning pain in your hands, arms, legs, or feet

• It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
• Tell your doctor if you have kidney disease, liver disease, diabetes, any infection, lung disease, or a history of tuberculosis or blood or bone marrow problems.
• This medicine may cause the following problems:Liver problemsSerious skin reactions, including drug reaction with eosinophilia and systemic reaction which can cause organ damagePossible increased risk of cancerNerve problemsLung problems
• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
• Unusual bleeding, bruising, or weakness
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor will also check your blood pressure.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.