Lidocaine-Prilocaine
Lidocaine-Prilocaine (Livixil Pak)
What is Lidocaine-Prilocaine?
Lidocaine-Prilocaine Cream (EMLA) is a prescription topical anesthetic used to numb the skin before medical procedures such as injections, blood draws, IV placement, laser treatments, and minor skin surgeries. It combines two local anesthetics to temporarily reduce pain and discomfort at the application site.
Side Effects
- Redness or pale skin at the application site
- Mild burning or stinging sensation
- Swelling at the site of application
Warnings
- Avoid contact with eyes. In case of accidental contact, rinse eyes thoroughly with water.
- Do not apply to broken or inflamed skin.
- Use with caution if you have a history of severe liver disease or methemoglobinemia.
- Do not use for prolonged periods or in large amounts without consulting a doctor.
- Seek immediate medical attention if experiencing difficulty breathing, face, lip, or tongue swelling, dizziness, or rash.
Prescription savings · · · ·
What is Lidocaine-Prilocaine ?
Lidocaine-Prilocaine Cream (EMLA) is a prescription topical anesthetic used to numb the skin before medical procedures such as injections, blood draws, IV placement, laser treatments, and minor skin surgeries. It combines two local anesthetics to temporarily reduce pain and discomfort at the application site.
- Redness or pale skin at the application site
- Mild burning or stinging sensation
- Swelling at the site of application
- Bruising or unusual sensations on the skin (tingling, itching)
- Changes in skin color at the site of application
- Blistering or peeling skin
- Avoid contact with eyes. In case of accidental contact, rinse eyes thoroughly with water.
- Do not apply to broken or inflamed skin.
- Use with caution if you have a history of severe liver disease or methemoglobinemia.
- Do not use for prolonged periods or in large amounts without consulting a doctor.
- Seek immediate medical attention if experiencing difficulty breathing, face, lip, or tongue swelling, dizziness, or rash.
- Consult your doctor before using if pregnant or breastfeeding.
Lidocaine-Prilocaine Coupons & Prices
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Lidocaine-Prilocaine prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 5gm of 2.5-2.5% · Tube Of Cream | 30 | $86.39 | $15.29 |
| 30gm of 2.5-2.5% · Tube Of Cream | 30 | $49.99 | $15.29 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a lidocaine-prilocaine coupon? Lidocaine and prilocaine (brand names EMLA and Oraqix) is a topical local anesthetic combination used to numb the skin or gum tissue before minor procedures. It is available as a lower-cost generic, but the cash price can vary widely from one pharmacy to another, so comparing matters. Rx.com checks prices across more than 60,000 pharmacies so you can find the best price near you. Enter your ZIP above to see today's price at pharmacies in your area.
What is lidocaine and prilocaine, and how does it work?
Lidocaine and prilocaine is a combination of two amide-type local anesthetics applied to the surface of the body rather than swallowed or injected. It temporarily blocks nerve signals in the treated area, producing local numbness so a procedure can be done with less pain.
The 2.5%/2.5% cream (EMLA) is FDA-approved for use on normal intact skin to provide local numbing before minor procedures such as needle insertion, venipuncture (blood draws), IV placement, and superficial skin surgery, and on genital mucous membranes before superficial minor surgery or as pretreatment for infiltration anesthesia. The periodontal gel form (Oraqix, 2.5%/2.5%) is approved to provide localized numbing in periodontal pockets during scaling and root planing at the dentist. Your provider or pharmacist can confirm which form and strength is right for your situation.
Lidocaine-prilocaine cost and savings without insurance
Lidocaine and prilocaine is available as a generic, which typically keeps it more affordable than a brand-name product. Even so, the cash price is not the same everywhere. Without insurance, what one pharmacy charges for the same tube or gel can differ from the pharmacy down the street, which is exactly why comparing prices is worth the few seconds it takes.
Rx.com compares live prices across 60,000+ pharmacies and shows you a coupon you can bring to the counter. There is no membership fee to use it. Enter your ZIP above to see today's price near you and pick the lowest option. Prices change, so we show them live on the page rather than quoting a fixed figure.
Related drugs and alternatives
Lidocaine and prilocaine combines two anesthetics that are also available on their own: lidocaine and prilocaine. The best-known brand of this specific combination is EMLA.
Other topical local anesthetics used to numb skin or surfaces include benzocaine and tetracaine. These products differ in their approved uses, strengths, and how they are applied, so which one is appropriate depends on the procedure and your provider's guidance. If you have a prescription for a specific product, you can compare its price using the tool above.
Safety and side effects
The most important risk with lidocaine and prilocaine is methemoglobinemia, a serious blood disorder that reduces how well the blood carries oxygen. Warning signs include pale, gray, or blue-tinged skin, headache, rapid heartbeat, shortness of breath, lightheadedness, and unusual tiredness. These symptoms can appear hours after the product is applied and need immediate medical attention. The risk is higher in infants under 12 months (especially under 6 months), people with G6PD deficiency, those with congenital or idiopathic methemoglobinemia, people with heart or lung problems, and anyone taking other medicines that can raise methemoglobin levels.
To use it safely, do not apply it to large areas of skin or leave it on longer than directed, and keep it away from the eyes. Applying too much can lead to nervous system or heart-related effects from the medicine being absorbed into the body. Common, usually temporary local reactions include paleness, redness, swelling, burning, or itching where it was applied. This information is for general education and is not medical advice; follow your provider's or pharmacist's directions and talk to them about your specific health situation.
This Lidocaine-Prilocaine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Lidocaine-Prilocaine on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.