Liothyronine Sodium
Liothyronine Sodium 5MCG
What is Liothyronine Sodium?
Liothyronine Sodium is a medication used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. It can also help with goiters and testing for hyperthyroidism.
Side Effects
- Bone pain
- Changes in skin color, dark freckles
- Chest pain, trouble breathing, fast or uneven heartbeat
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, diabetes, blood clotting problems, adrenal gland problems, or pituitary gland problems.
- This medicine may cause the following problems:Heart and heart rhythm problemsMyxedema coma, which may be life-threateningAdrenal gland problemsLow bone mineral density
- Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will replace a hormone that is normally produced by your thyroid gland. You may have to take this medicine for the rest of your life.
- Tell any doctor or dentist who treats you that you are using this medicine.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Prescription savings · · · ·
What is Liothyronine Sodium ?
Liothyronine Sodium is a medication used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. It can also help with goiters and testing for hyperthyroidism.
- Bone pain
- Changes in skin color, dark freckles
- Chest pain, trouble breathing, fast or uneven heartbeat
- Cold feeling, weakness, tiredness, nausea, vomiting, weight loss, confusion
- Leg cramps, headache, nervousness, irritability, tremors, excessive sweating, heat intolerance, fever, changes in menstrual periods
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Rapid weight gain, swelling in your face, hands, ankles, or feet
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, diabetes, blood clotting problems, adrenal gland problems, or pituitary gland problems.
- This medicine may cause the following problems:Heart and heart rhythm problemsMyxedema coma, which may be life-threateningAdrenal gland problemsLow bone mineral density
- Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will replace a hormone that is normally produced by your thyroid gland. You may have to take this medicine for the rest of your life.
- Tell any doctor or dentist who treats you that you are using this medicine.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Liothyronine Sodium Coupons & Prices
Liothyronine Sodium 5MCG
Weight-loss medication, prescribed online
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Looking for a liothyronine sodium coupon? Liothyronine sodium is the generic form of the thyroid hormone T3 (sold under brand names like Cytomel), and because it is already available as a generic it usually costs far less than the brand. Even so, the cash price can vary a lot from one pharmacy to the next, so it pays to compare. Enter your ZIP above to see today's price at pharmacies near you — Rx.com checks discounts across more than 60,000 U.S. pharmacies so you can find a lower price on your prescription.
What is liothyronine sodium and how does it work?
Liothyronine sodium is a synthetic form of triiodothyronine (T3), one of the two main hormones your thyroid gland normally makes. When your thyroid does not make enough hormone, your body slows down. Liothyronine replaces the missing T3 so your metabolism can work more normally. It is FDA-approved to treat hypothyroidism (an underactive thyroid) and, as an adjunct to surgery and radioiodine, to help manage well-differentiated thyroid cancer. It is also used as a diagnostic agent in the T3 suppression test. The injectable form (Triostat) is used in a hospital for myxedema coma, a severe form of hypothyroidism.
Liothyronine is sometimes added to levothyroxine (T4) therapy, or used in other situations, at a doctor's discretion. Any use should be guided by your prescriber and follow-up blood tests — this page is general information, not medical advice.
Cost of liothyronine sodium without insurance
Liothyronine sodium is available as a generic, which typically makes it much more affordable than brand-name Cytomel. But "generic" does not mean every pharmacy charges the same amount — cash prices for the same tablet strength and quantity can differ widely between pharmacies, even ones on the same street. That is exactly why comparing before you fill matters.
Rx.com compares discount prices across more than 60,000 pharmacies so you can see where liothyronine is cheapest near you. There is no manufacturer copay savings card for generic liothyronine sodium, so a discount coupon is often the most reliable way to lower the cash price. Enter your ZIP above to see today's price and print or show the coupon at the pharmacy. If you have insurance, it is worth comparing the coupon price against your copay, since the discount price is sometimes lower.
Liothyronine vs. levothyroxine and other thyroid options
Liothyronine is T3; the most commonly prescribed thyroid medicine, levothyroxine, is T4. Your body converts T4 into the active T3 hormone over time, so levothyroxine gives a steady, long-acting effect, while liothyronine acts faster and is shorter-lasting. Many people do well on levothyroxine (brand Synthroid) alone; some are prescribed T3 in addition. Which is right for you is a decision for your doctor based on your labs and symptoms.
Related thyroid medicines you can compare on Rx.com include the brand version of this drug, Cytomel, and the natural desiccated thyroid products Armour Thyroid and NP Thyroid, which contain both T4 and T3. Do not switch between these on your own — they are not interchangeable dose-for-dose.
Safety, side effects, and important warnings
Liothyronine should not be used for weight loss or to treat obesity. In people with normal thyroid function, ordinary doses do not help with weight, and larger doses can cause serious, even life-threatening effects — especially if combined with stimulant (sympathomimetic) drugs such as amphetamines. Taking too much thyroid hormone can cause symptoms of an overactive thyroid: a fast or pounding heartbeat, chest pain, tremor, sweating, feeling too warm, unwanted weight loss, nervousness, and trouble sleeping. Over the long term, too much can weaken bones.
Tell your doctor about heart problems (such as angina, coronary artery disease, or an irregular heartbeat), diabetes, or if you take a blood thinner like warfarin, since liothyronine can change how those are managed. Older adults and people with heart disease are usually started at a low dose. It should not be used in untreated overactive thyroid (thyrotoxicosis) or uncorrected adrenal insufficiency. This is a summary, not a complete list — talk with your doctor or pharmacist about your full history and any side effects.
This Liothyronine Sodium information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Liothyronine Sodium on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.