Misoprostol
Misoprostol
What is Misoprostol?
Misoprostol is used to prevent stomach ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDS). Misoprostol is a generic drug. The average price of Misoprostol is about $12 for a supply of 2, 200 mcg tablets.You can use our Rx.com savings offer to get an average Misoprostol discount of up to 80% off of the retail price at participating pharmacies near you.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Unusual bleeding or bruising, including heavy vaginal bleeding
- Vaginal bleeding after menopause
Warnings
- Do not use this medicine if you are pregnant or planning to become pregnant. This medicine can cause miscarriage, premature birth, or birth defects if taken during pregnancy. You will need to have a negative pregnancy test within 2 weeks before you start using this medicine. Continue to use birth control for at least 1 month after you stop using this medicine. Tell your doctor right away if you become pregnant.
- Begin using this medicine on the 2nd or 3rd day of your next monthly period. This is to make sure you are not pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel problems, bowel problems, or a history of stomach ulcers.
- This medicine may cause diarrhea in some people. The diarrhea will usually disappear within a few days as your body adjusts to the medicine. However, check with your doctor if the diarrhea is severe or does not stop after a week.
- It is dangerous for anyone else to use your medicine. Do not give this medicine to another person. Keep your unused tablets in a safe and secure place.
Prescription savings · · · ·
What is Misoprostol ?
Misoprostol is used to prevent stomach ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDS). Misoprostol is a generic drug. The average price of Misoprostol is about $12 for a supply of 2, 200 mcg tablets.You can use our Rx.com savings offer to get an average Misoprostol discount of up to 80% off of the retail price at participating pharmacies near you.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Unusual bleeding or bruising, including heavy vaginal bleeding
- Vaginal bleeding after menopause
- Do not use this medicine if you are pregnant or planning to become pregnant. This medicine can cause miscarriage, premature birth, or birth defects if taken during pregnancy. You will need to have a negative pregnancy test within 2 weeks before you start using this medicine. Continue to use birth control for at least 1 month after you stop using this medicine. Tell your doctor right away if you become pregnant.
- Begin using this medicine on the 2nd or 3rd day of your next monthly period. This is to make sure you are not pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel problems, bowel problems, or a history of stomach ulcers.
- This medicine may cause diarrhea in some people. The diarrhea will usually disappear within a few days as your body adjusts to the medicine. However, check with your doctor if the diarrhea is severe or does not stop after a week.
- It is dangerous for anyone else to use your medicine. Do not give this medicine to another person. Keep your unused tablets in a safe and secure place.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Misoprostol Coupons & Prices
Misoprostol
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Misoprostol prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 1gm of 1% · Bottle | 1 | $122.99 | $98.50 |
| 2 tablets · Bottle | 1 | $15.49 | $13.39 |
| 4 tablets · Bottle | 4 | $24.75 | $8.99 |
| 5gm of 1% · Bottle | 5 | $526.99 | $434.10 |
| 8 tablets · Bottle | 8 | $76.59 | $58.13 |
| 30 tablets · Bottle | 6 | $69.69 | $41.48 |
| 60 tablets · Bottle | 12 | $22.39 | $14.79 |
| 100 tablets · Bottle | 60 | $75.59 | $26.65 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a misoprostol coupon? Misoprostol is the generic form of Cytotec, a prescription medicine FDA-approved to reduce the risk of stomach (gastric) ulcers in people who must take NSAID pain relievers and are at high risk of ulcer complications. As a generic, misoprostol is already one of the lower-cost prescription options, but the cash price can vary widely from one pharmacy to the next, so it pays to compare. Rx.com checks prices across more than 60,000 pharmacies so you can find the best price near you. Enter your ZIP above to see today's price and print or text yourself a free discount coupon.
What is misoprostol and how does it work?
Misoprostol is a synthetic prostaglandin E1 analog. It works on the lining of the stomach in two ways: it reduces the amount of acid the stomach makes and helps protect the stomach lining. Because NSAID pain relievers (such as ibuprofen, naproxen, and diclofenac) can wear down that protective lining and cause ulcers, misoprostol is FDA-approved to lower the risk of NSAID-induced gastric ulcers in people at high risk of ulcer complications, such as older adults, people with a history of ulcers, or those with a debilitating illness who must keep taking an NSAID.
Misoprostol is a prostaglandin, so it can also affect the uterus. Because of this, it is widely used in obstetrics and gynecology, though those uses are off-label rather than part of its FDA-approved stomach-protection labeling. If your prescriber has recommended misoprostol, follow their directions exactly; this page is general information, not medical advice.
Misoprostol cost and coupons without insurance
Misoprostol is available as an FDA-approved generic, which is why it is usually far less expensive than brand-name Cytotec. Even so, the cash price is not the same everywhere. Two pharmacies on the same street can charge noticeably different amounts for the exact same tablets, so comparing prices is the single easiest way to save. That matters whether or not you have insurance, since a discount-coupon price is sometimes lower than an insurance copay.
Rx.com compares misoprostol prices across more than 60,000 U.S. pharmacies and gives you a free discount coupon you can use at the counter. There is no membership required. Enter your ZIP code above to see today's price near you, then show the coupon to your pharmacist.
Related medicines and alternatives
Misoprostol is the generic of the brand Cytotec; the two contain the same active ingredient, so most people can save by choosing the generic. Misoprostol is also combined with the NSAID diclofenac in the branded product Arthrotec, which pairs anti-inflammatory relief with stomach protection in one tablet. If you take an NSAID and are worried about ulcers, your prescriber might instead consider a stomach-acid reducer such as omeprazole, or the standalone NSAID diclofenac.
Misoprostol is a different medicine from mifepristone, though the two are sometimes discussed together. Only your prescriber can decide which option fits your situation. You can compare prices on any of these medicines on Rx.com by entering your ZIP code.
Important safety information
Misoprostol carries a prominent boxed warning. Because it acts on the uterus, it can cause miscarriage (abortion), premature birth, birth defects (including skull, cranial nerve, facial, and limb defects), and uterine rupture. For this reason, when used for the FDA-approved ulcer indication, misoprostol must not be taken during pregnancy. The risk of uterine rupture is higher later in pregnancy and in women who have had prior uterine surgery or a Cesarean delivery, or who have had many prior pregnancies. Women who can become pregnant should have a negative pregnancy test before starting and use effective birth control while taking it. Never share this medicine with anyone else.
The most common side effects are diarrhea and abdominal (stomach) pain, which are often mild and may ease over time. Misoprostol should not be used by anyone allergic to prostaglandins. This is a summary, not a complete list of risks. Talk with your doctor or pharmacist about your full health history and any other medicines you take before starting misoprostol.
This Misoprostol information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Misoprostol on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.