What is Mitoxantrone Hcl ?

Mitoxantrone hydrochloride is a synthetic antineoplastic agent, chemically related to anthracenediones, with antitumor and immunomodulatory properties. It intercalates into DNA and inhibits topoisomerase II, leading to disruption of DNA synthesis and repair, ultimately inducing apoptosis in susceptible cells. Mitoxantrone is primarily used in the treatment of certain types of cancer, including acute myeloid leukemia, non-Hodgkin's lymphoma, and prostate cancer, as well as in the management of multiple sclerosis.

• Uncontrollable nausea, vomiting, or diarrhea.
• Unusual tiredness or weakness.
• Swelling in your hands, ankles, or feet.
• Unusual bleeding or bruising.
• Uneven heartbeats.
• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Burning, pain, swelling, or bruising of your skin where the needle is placed.
• Fever, chills, cough, runny or stuffy nose, sore throat, and body aches.
• Nausea, vomiting, loss of appetite, or pain in your upper stomach.
• Pain or burning when you urinate, change in how much or how often you urinate.
• Pain or redness at the place of injection.
• Rapid weight gain.
• Shortness of breath, cold sweat, and bluish-colored skin.
• Yellowing of your skin or the whites of your eyes.

• Injection routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Your doctor may require you to have a pregnancy test before you receive each dose of this medicine, to make sure you are not pregnant.
• Make sure your doctor knows if you have liver disease, anemia, blood clotting problems, bone marrow problems, low white blood cell counts, bleeding problems, or any kind of infection. Also, tell your doctor if you have had cancer treatment or radiation in the past.
• Make sure your doctor knows if you have heart or blood vessel disease, congestive heart failure, or any type of swelling (such as in your ankles, feet, or hands). Your doctor may need to check your heart function before you start using this medicine.
• If you have pain, burning, redness, or swelling of your skin area where the IV needle is placed, tell your doctor right away.
• This medicine may change the color of your urine to bluish-green. The whites of your eyes may also appear slightly bluish-green. This is normal, especially within the first 24 hours after you receive the medicine.
• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor may also want to check your heart while you are using this medicine.
• Injection routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.
• Swelling in your hands, ankles, or feet.
• Uncontrollable nausea, vomiting, or diarrhea.
• Uneven heartbeats.
• Unusual bleeding or bruising.
• Unusual tiredness or weakness.
• Yellowing of your skin or the whites of your eyes.