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Podofilox

Podofilox

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What is Podofilox?

Podofilox (Condylox) is a prescription topical medication used to treat external genital and perianal warts caused by the human papillomavirus (HPV). It works by destroying wart tissue, helping the warts shrink and eventually disappear. 

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What is Podofilox ?

Podofilox (Condylox) is a prescription topical medication used to treat external genital and perianal warts caused by the human papillomavirus (HPV). It works by destroying wart tissue, helping the warts shrink and eventually disappear. 

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bleeding, swelling, or severe pain
  • Tell your doctor if you are pregnant or breastfeeding.
  • Call your doctor if the warts are not gone after 4 weeks of treatment.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is podofilox used to treat?
Podofilox is a prescription topical medicine used to treat external genital warts (condylomata acuminata), which are caused by HPV. The 0.5% gel is FDA-approved for external genital and perianal warts, while the 0.5% solution is approved for external genital warts only. It is not used for warts on mucous membranes or for cervical, urethral, or internal warts.
How do you apply podofilox gel or solution?
Podofilox is usually applied to the visible external warts twice a day for 3 days, then not used for the next 4 days. This weekly cycle can be repeated for up to 4 cycles if your clinician directs. Apply it only to the wart tissue and avoid the surrounding healthy skin, keep it away from your eyes, and follow the exact directions your prescriber gives you.
How long does it take for podofilox to clear genital warts?
Podofilox is used in weekly treatment cycles, and warts may clear over the course of up to 4 cycles. Response varies from person to person. Keep in mind that podofilox removes visible warts but does not eradicate the underlying HPV, so warts commonly come back and may need further treatment. Ask your clinician what to expect in your case.
Is podofilox the same as Condylox?
Yes. Podofilox is the active ingredient in the brand-name product Condylox, and podofilox is available as a lower-cost generic. Both contain the same medicine at 0.5% strength. Prices for the generic can vary by pharmacy, so it is worth comparing before you fill.
Can you use podofilox while pregnant?
No. Podofilox should not be used during pregnancy because of the potential for harm to the baby. If you are pregnant, could become pregnant, or are breastfeeding, talk with your clinician first, and discuss effective contraception. This is general information, not medical advice, so follow your provider's guidance.
How much does Podofilox 3.5ML of 0.5% cost without insurance?
The price of Podofilox 3.5ML of 0.5% without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Podofilox 3.5ML of 0.5%?
Common side effects of Podofilox 3.5ML of 0.5% may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Bleeding, swelling, or severe pain. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Podofilox 3.5ML of 0.5%?
Generic versions may be available for Podofilox 3.5ML of 0.5%. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Podofilox 3.5ML of 0.5% on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Podofilox 3.5ML of 0.5%?
The cheapest pharmacy for Podofilox 3.5ML of 0.5% depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Podofilox 3.5ML of 0.5% near you.

Podofilox Coupons & Prices

Podofilox

Prescriptions & Refills
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Podofilox Bottle — prescription drug image
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Podofilox prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
1gm of · Bottle 1 $69.59 $52.92
3.5ml of 0.5% · Bottle 3.5 $116.99 $93.14

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a podofilox coupon? Podofilox (the active ingredient in the brand Condylox) is a prescription topical gel and solution used to treat external genital and perianal warts. It is available as a lower-cost generic, but the cash price can vary widely from one pharmacy to the next. Rx.com compares prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see the current price on podofilox at pharmacies in your area.

What is podofilox and how does it work?

Podofilox (also known as podophyllotoxin) is a topical keratolytic and antimitotic medicine used to treat external genital warts (condylomata acuminata), which are caused by the human papillomavirus (HPV). It works by causing the visible wart tissue to break down and die off over repeated treatment cycles. The 0.5% gel is FDA-approved for external genital and perianal warts, while the 0.5% solution is approved for external genital warts only (not perianal warts).

Podofilox is applied only to the visible warts on external skin. It is not intended for warts on mucous membranes or for cervical, urethral, or internal warts. It is worth knowing that podofilox treats the warts you can see but does not cure the underlying HPV infection, so warts can come back after treatment.

Podofilox cost and coupons without insurance

Podofilox is available as a generic, which is typically much less expensive than the brand-name Condylox. Even so, the cash price for the same prescription can differ significantly from pharmacy to pharmacy, so it pays to compare before you fill. With or without insurance, a discount price shown on Rx.com is sometimes lower than a standard pharmacy cash price.

Because prices change and depend on your location, we show live pricing on this page. Enter your ZIP above to see today's price on podofilox and a coupon you can bring to the pharmacy. Rx.com compares more than 60,000 pharmacies so you can pick the lowest option near you.

Podofilox alternatives and related treatments

Podofilox is one of several topical options for external genital warts. The brand-name version is Condylox. Other prescription topicals your clinician may consider include imiquimod (brand Aldara), an immune-response cream, and sinecatechins (brand Veregen), a green-tea-derived ointment.

These medicines work in different ways and have different application schedules, so the right choice depends on your situation and your provider's guidance. Comparing prices across brand and generic options can help you and your clinician land on an effective treatment that also fits your budget.

Safety and how to use podofilox

Podofilox is typically applied to external warts twice a day for 3 days, followed by 4 days with no treatment, and this weekly cycle may be repeated for up to 4 cycles as directed. Apply it only to the wart tissue and avoid the surrounding healthy skin. Common local reactions include burning, pain, inflammation, erosion, and itching. Avoid contact with the eyes, and if the medicine gets in your eyes, flush them with water. The gel is flammable, so keep it away from open flame.

Podofilox should not be used during pregnancy because of the potential for harm to the baby; talk with your clinician about effective contraception and about breastfeeding. Avoid intercourse on the days you apply the medicine. This information is not a substitute for medical advice, so follow your prescriber's instructions and reach out to your pharmacist or clinician with any questions.

Sources & accuracy

This Podofilox information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Podofilox on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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