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Pseudoephedrine Hcl Er

Pseudoephedrine HCl ER 10 Tablets Extended Release 12 Hour

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What is Pseudoephedrine Hcl Er?

Pseudoephedrine HCl ER is a medication used to relieve nasal congestion caused by allergies or colds. It helps to open up the nasal passages, making it easier to breathe.

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What is Pseudoephedrine Hcl Er ?

Pseudoephedrine HCl ER is a medication used to relieve nasal congestion caused by allergies or colds. It helps to open up the nasal passages, making it easier to breathe.

Source: MedlinePlus, U.S. National Library of Medicine

  • Convulsions (seizures)
  • Hallucinations
  • Severe restlessness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain
  • Very fast, pounding, or irregular heartbeat
  • Wheezing or shortness of breath
  • Check with your doctor before using if you are pregnant or breastfeeding, or if you have heart disease, high blood pressure, diabetes, trouble urinating due to an enlarged prostate, or an overactive thyroid.
  • You should not use this medicine for more than 7 days unless ordered by a doctor.
  • If you do not get better after using this medicine for 7 days, or if you have a fever, talk to your doctor.
  • Wheezing or shortness of breath
  • Convulsions (seizures)
  • Severe restlessness
  • Hallucinations
Is pseudoephedrine HCl ER available over the counter?
Yes. Pseudoephedrine does not require a prescription, but under a federal law (the Combat Methamphetamine Epidemic Act) it is kept behind the pharmacy counter. You ask the pharmacy staff for it, show a photo ID, and sign a log, and there are limits on how much you can buy in a set period.
How long does 12-hour and 24-hour pseudoephedrine last?
The extended-release tablets release the medicine slowly. The 120 mg tablet is made to relieve congestion for about 12 hours, and the 240 mg tablet is made to last about 24 hours. Do not take more than the label directs, even if symptoms return before the next scheduled dose.
Can I take pseudoephedrine if I have high blood pressure?
Ask a doctor or pharmacist first. Pseudoephedrine narrows blood vessels and can raise blood pressure and heart rate, so it may not be a good choice if you have high blood pressure or heart disease. Your provider can suggest a safer option for controlling congestion.
What is the difference between pseudoephedrine and phenylephrine?
Both are decongestants, but they are different drugs. Pseudoephedrine is kept behind the pharmacy counter and requires showing ID. Phenylephrine is sold on the open shelf in many "PE" cold products. They are not interchangeable, so check the active ingredient on the label.
Why is pseudoephedrine kept behind the pharmacy counter?
Pseudoephedrine can be misused to illegally make methamphetamine. A federal law, the Combat Methamphetamine Epidemic Act, requires stores to keep it behind the counter, check a buyer's photo ID, log the sale, and enforce limits on how much can be purchased over time.
How much does Pseudoephedrine Hcl Er cost without insurance?
The price of Pseudoephedrine Hcl Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Pseudoephedrine Hcl Er?
Common side effects of Pseudoephedrine Hcl Er may include: Convulsions (seizures), Hallucinations, Severe restlessness, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Chest pain. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Pseudoephedrine Hcl Er?
Generic versions may be available for Pseudoephedrine Hcl Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Pseudoephedrine Hcl Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Pseudoephedrine Hcl Er?
The cheapest pharmacy for Pseudoephedrine Hcl Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Pseudoephedrine Hcl Er near you.

Pseudoephedrine Hcl Er Coupons & Prices

Pseudoephedrine HCl ER 10 Tablets Extended Release 12 Hour

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Pseudoephedrine HCl ER is an extended-release nasal decongestant sold over the counter as Sudafed 12 Hour and Sudafed 24 Hour, and as store-brand generics. Even though you do not need a prescription, a free Rx.com pseudoephedrine HCl ER coupon can help you compare what different pharmacies charge and pay less when you pick it up at the counter. Enter your ZIP above to see today's price near you.

What pseudoephedrine HCl ER is and how it works

Pseudoephedrine hydrochloride is a nasal decongestant in the sympathomimetic (alpha-adrenergic agonist) class. It relieves the stuffy, congested feeling in your nose and sinuses by narrowing the swollen blood vessels in your nasal passages, which opens the airways and eases sinus pressure. It is used for the temporary relief of nasal and sinus congestion and pressure caused by the common cold, hay fever, or other upper respiratory allergies. It treats the symptom, not the underlying cause, and it does not make a cold go away faster.

The extended-release (ER) tablets release the medicine slowly over time, so you take fewer doses per day. The 120 mg tablet is designed to last about 12 hours, and the 240 mg tablet is designed to last about 24 hours. ER forms are intended for adults and children 12 years and older.

Saving on pseudoephedrine HCl ER with an Rx.com coupon

Because pseudoephedrine ER is behind-the-counter rather than on the open shelf, the price can vary quite a bit from one pharmacy to another. It is an over-the-counter product, but some pharmacies will still ring it up against a discount coupon, and in some cases asking your prescriber to write it as a prescription can unlock a lower cash price. An Rx.com coupon is free to use and works like a cash-discount card at the register.

To check what you would pay, enter your ZIP code above to see today's price at nearby pharmacies, then show the coupon at the counter when you buy. Prices change over time and by location, so it is worth comparing the 12-hour and 24-hour strengths and the store-brand generic, which is the same medicine as the Sudafed brand.

How it compares to other congestion and allergy options

Pseudoephedrine is often confused with phenylephrine, the decongestant found in many "PE" cold products sold on the open shelf. They are not the same drug, and pseudoephedrine is the one kept behind the pharmacy counter. If your congestion comes along with sneezing, itching, or a runny nose from allergies, an antihistamine such as cetirizine, loratadine, or fexofenadine may help more with those symptoms.

For allergy sufferers who also need decongestion, there are combination products that pair an antihistamine with pseudoephedrine in one tablet, such as fexofenadine-pseudoephedrine and loratadine-pseudoephedrine. Another single-ingredient decongestant option is phenylephrine. Ask your pharmacist which fits your symptoms, and compare prices on each with a coupon before you decide.

Important safety information

Pseudoephedrine HCl ER has no FDA boxed warning, but it is not right for everyone. Do not use it if you are taking, or have taken within the past 2 weeks, an MAO inhibitor (a type of medicine for depression, psychiatric conditions, or Parkinson's disease). Ask a doctor before use if you have high blood pressure, heart disease, thyroid disease, diabetes, or trouble urinating due to an enlarged prostate, because pseudoephedrine can raise blood pressure and heart rate. People with a narrowing or stricture of the digestive tract should avoid the 24-hour ER tablet. ER forms are not for children under 12.

Possible effects include nervousness, dizziness, sleeplessness, headache, and a fast, pounding, or irregular heartbeat. Stop use and ask a doctor if nervousness, dizziness, or sleeplessness happens, if symptoms last more than 7 days, or if they come with a fever. Do not take more than the label recommends. This is general information, not medical advice, so check with your doctor or pharmacist about your own situation.

Sources & accuracy

This Pseudoephedrine Hcl Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Pseudoephedrine Hcl Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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