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Sprix

Sprix 1 Solution

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What is Sprix?

Sprix is a nonsteroidal anti-inflammatory drug used treat mild to severe pain in patients recovering from surgery. There is not a Sprix generic drug currently available on the market. Sprix costs around $944 for a supply of 5, 15.75 mg sprays, but luckily there are ways to save money. You can use our Rx.com Sprix savings card to save significantly on the retail price at participating pharmacies near you.

Prescription savings · · · ·

What is Sprix ?

Sprix is a nonsteroidal anti-inflammatory drug used treat mild to severe pain in patients recovering from surgery. There is not a Sprix generic drug currently available on the market. Sprix costs around $944 for a supply of 5, 15.75 mg sprays, but luckily there are ways to save money. You can use our Rx.com Sprix savings card to save significantly on the retail price at participating pharmacies near you.
  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, or problems with vision, speech, or walking
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
  • Red or black stools, severe stomach pain, vomiting blood or material that looks like coffee grounds
  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, unusual sweating, fainting
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Blistering, peeling, or red skin rash
  • Change in how much or how often you urinate
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Red or black stools, severe stomach pain, vomiting blood or material that looks like coffee grounds
  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, or problems with vision, speech, or walking
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • This medicine may cause the following problems: Higher risk of blood clots, heart failure, heart attack, or strokeBleeding in your stomach or intestinesLiver problemsHigh blood pressureKidney problems and high potassium levelsSerious skin reactions
  • Tell your doctor if you have kidney disease, liver disease, asthma, anemia, blood clotting problems, heart failure, high blood pressure, heart or blood vessel problems, a recent heart attack, or a history of stomach ulcers or bleeding problems. Tell your doctor if you drink alcohol.
  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
What is Sprix nasal spray used for?
Sprix is FDA-approved for the short-term (up to 5 days) management of moderate to moderately severe pain in adults that requires analgesia at the opioid level, such as pain after surgery. It is a nasal-spray form of the NSAID ketorolac.
How long can you use Sprix?
No more than 5 days. The FDA label limits total ketorolac therapy from all routes combined (nasal spray, oral, and injectable) to a maximum of 5 days. It is only for short-term, acute pain, not ongoing or chronic pain.
Is Sprix an opioid or a narcotic?
No. Sprix is not an opioid or a narcotic and is not a controlled substance. It is a nonsteroidal anti-inflammatory drug (NSAID) containing ketorolac. It is strong enough to treat pain at the opioid level, but it works through a different, non-opioid mechanism.
Is there a generic version of Sprix?
No. There is currently no FDA-approved, substitutable generic of the Sprix nasal spray. The same active ingredient, ketorolac, is available as an affordable generic in oral tablet and injectable forms, but those are given differently and are not direct substitutes for the nasal spray.
How much does Sprix cost with a savings card?
The price depends on your pharmacy, location, and coverage. The manufacturer's Sprix Direct program is generally for people with commercial insurance and its terms vary, so check the current rules. If you are uninsured, on Medicare, or the card is declined, enter your ZIP above to see today's Rx.com cash price near you.
How much does Sprix cost without insurance?
The price of Sprix without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Sprix?
Common side effects of Sprix may include: Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, or problems with vision, speech, or walking, Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes, Red or black stools, severe stomach pain, vomiting blood or material that looks like coffee grounds, Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, unusual sweating, fainting, Rapid weight gain, swelling in your hands, ankles, or feet. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Sprix?
Generic versions may be available for Sprix. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Sprix on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Sprix?
The cheapest pharmacy for Sprix depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Sprix near you.

Sprix Coupons & Prices

Sprix 1 Solution

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Sprix Spray Btl — prescription drug image
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a Sprix coupon? Sprix is a brand-name prescription nasal spray that delivers ketorolac tromethamine, a nonsteroidal anti-inflammatory drug (NSAID), for the short-term relief of moderate to moderately severe pain in adults. Because there is no substitutable generic of the Sprix nasal spray, the price can be high at the pharmacy counter. An Rx.com cash coupon can lower what you pay whether or not you have insurance. Enter your ZIP above to see today's price at pharmacies near you.

What is Sprix and how does it work?

Sprix is a nasal-spray form of ketorolac tromethamine, an NSAID. Like other NSAIDs, ketorolac lowers pain and inflammation by blocking the enzymes (COX) your body uses to make prostaglandins. What sets ketorolac apart is its strength: it is FDA-approved for moderate to moderately severe pain that requires analgesia at the opioid level, without being an opioid itself. The nasal spray is used for acute short-term pain, such as pain after surgery.

Sprix is meant for short-term use only. The FDA label limits total ketorolac therapy, by all routes combined (nasal, oral, and injectable), to no more than 5 days. It is not a maintenance medicine for chronic or long-lasting pain. Always follow your prescriber's directions; this page is educational and not a substitute for medical advice.

Sprix cost: manufacturer savings card vs. Rx.com cash coupon

The manufacturer runs an official savings program, Sprix Direct, described on the brand's own website (sprix.com). Manufacturer copay cards like this are generally limited to people with commercial (private) insurance, and the exact terms, eligibility, and any expiration change over time, so read the current rules before you rely on it. These cards typically cannot be used if you are uninsured or covered by Medicare, Medicaid, or another government program.

That is where an Rx.com cash coupon helps. Our coupon is a cash-price discount, not insurance, so it works for the uninsured, for people with Medicare or Medicaid, and any time a manufacturer card is declined or you simply want to compare. You cannot combine a cash coupon with insurance on the same fill, but you are free to choose whichever route costs less that day. Enter your ZIP above to see today's Sprix price at pharmacies near you. If cost is a barrier, ask your prescriber or the manufacturer about patient-assistance options as well.

Sprix alternatives and related NSAIDs

Sprix contains the same active ingredient, ketorolac, as the injectable and oral forms sold under the brand Toradol and as generic ketorolac. Those other ketorolac forms do have affordable generics, though they are given differently, so the nasal spray is not always interchangeable with them.

For other pain and inflammation needs, prescribers may consider other NSAIDs, many of which are available as low-cost generics:

  • Diclofenac - an NSAID available in oral and topical forms
  • Meloxicam - a once-daily NSAID often used for arthritis
  • Celecoxib - a COX-2 selective NSAID

These medicines differ in how they are taken and how long they are used. Only your prescriber can decide which option fits your pain and your health history.

Sprix safety and boxed warning

Sprix carries the NSAID BOXED WARNING. NSAIDs can raise the risk of serious cardiovascular events such as heart attack and stroke, and serious gastrointestinal bleeding, ulcers, and perforation, which can happen without warning. Ketorolac also inhibits platelet function, so it increases bleeding risk. Because of this, it is contraindicated before major surgery (including coronary artery bypass graft, or CABG, surgery), in people with active peptic ulcer disease or a recent GI bleed, and in those at high risk of bleeding.

Sprix is also contraindicated during labor and delivery, in nursing mothers, in advanced kidney impairment or people at risk of kidney failure, and when taken with aspirin, other NSAIDs, probenecid, or pentoxifylline. It can cause kidney problems, high blood pressure, heart failure, and severe allergic (anaphylactoid) reactions. Do not exceed 5 days of total ketorolac therapy. Tell your prescriber about all your conditions and medicines, and get emergency help for chest pain, weakness on one side, black or bloody stools, or trouble breathing. This is general information, not medical advice.

Sources & accuracy

This Sprix information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Sprix on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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