Tresiba
Tresiba
What is Tresiba?
Insulin Degludec is the generic (unbranded) version of Tresiba®, an ultra-long-acting basal insulin used to improve blood sugar control in adults and children with type 1 and type 2 diabetes. It provides up to 42 hours of blood sugar control with a convenient once-daily injection.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting, uneven heartbeat
- Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart failure.
- This medicine may cause the following problems:Low blood sugar or low potassium levels in the bloodFluid retention or heart failure (when used together with a thiazolidinedione [TZD] medicine)
- This medicine can cause low blood sugar. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Never share insulin pens or needles with anyone. Sharing these can pass hepatitis viruses, HIV, or other illnesses from one person to another.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Prescription savings · · · ·
What is Tresiba ?
Insulin Degludec is the generic (unbranded) version of Tresiba®, an ultra-long-acting basal insulin used to improve blood sugar control in adults and children with type 1 and type 2 diabetes. It provides up to 42 hours of blood sugar control with a convenient once-daily injection.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting, uneven heartbeat
- Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
- Rapid weight gain, swelling in your hands, ankles, or feet, chest pain, trouble breathing, tiredness
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart failure.
- This medicine may cause the following problems:Low blood sugar or low potassium levels in the bloodFluid retention or heart failure (when used together with a thiazolidinedione [TZD] medicine)
- This medicine can cause low blood sugar. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Never share insulin pens or needles with anyone. Sharing these can pass hepatitis viruses, HIV, or other illnesses from one person to another.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Tresiba Coupons & Prices
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Looking for a Tresiba coupon? Tresiba (insulin degludec) is a once-daily long-acting (basal) insulin used to improve blood sugar control in adults and children 1 year and older with type 1 or type 2 diabetes. There is no generic version yet, so the brand can be costly at the pharmacy. The Rx.com cash coupon on this page can lower the price whether you are uninsured, on Medicare, or paying cash. Enter your ZIP code above to see today's price at pharmacies near you.
What is Tresiba and how does it work?
Tresiba (insulin degludec) is a long-acting, or basal, human insulin analog. It is FDA-approved to improve glycemic control (blood sugar control) in adults and pediatric patients 1 year of age and older who have type 1 or type 2 diabetes and require insulin. It is taken once daily and works steadily in the background to help keep blood sugar in range between meals and overnight.
Tresiba is a basal insulin, not a mealtime insulin. In type 1 diabetes it must be used together with a short-acting (mealtime) insulin such as NovoLog or Humalog. In type 2 diabetes it may be combined with mealtime insulin or with oral antidiabetic medicines. It comes in two strengths (U-100 and U-200), and Tresiba is not used to treat diabetic ketoacidosis. Your provider will set your dose and adjust it over time.
Tresiba cost: manufacturer savings card vs. Rx.com cash coupon
The "Tresiba coupon" search results are usually dominated by the manufacturer's savings card and by discount-card sites. It helps to know how these differ. Novo Nordisk offers an official Tresiba savings card through NovoCare. Manufacturer copay cards like this are generally limited to people with commercial (private) insurance and are not available to people with government coverage such as Medicare or Medicaid. Terms, eligibility, and any limits are set by the manufacturer and can change, so check the official page for current details: Tresiba savings offer (NovoCare).
The Rx.com cash coupon works differently. It is a cash-price discount, so it can help when you are uninsured, covered by Medicare or Medicaid, or when the manufacturer card is declined. You do not use it together with insurance; you use it instead of insurance as a cash payment. Because there is no generic insulin degludec yet, comparing the cash price across pharmacies is one of the best ways to save. Enter your ZIP code above to see today's Tresiba price at pharmacies near you. Novo Nordisk also runs patient assistance programs for people who qualify based on income and insurance status; you can ask about eligibility through NovoCare.
Tresiba alternatives and how it compares
Tresiba is one of several long-acting basal insulins. Others your provider may discuss include Lantus, Basaglar, and Toujeo (all insulin glargine products), and Levemir (insulin detemir). These are all basal insulins, but they differ in how long they last and in how they are dosed, so they are not automatically interchangeable.
Tresiba is also sold as Tresiba FlexTouch, the prefilled pen form, and the active ingredient is insulin degludec. Only your provider can decide whether switching insulins is right for you, since any change requires careful dose adjustment and blood sugar monitoring. If cost is your main concern, comparing the cash price of each option on Rx.com can help you and your provider weigh the choices.
Tresiba safety: what to know
Tresiba does not carry a boxed warning, but there are important safety points. The most common risk is hypoglycemia (low blood sugar), which can be severe and even life-threatening. This risk goes up with dose changes, changes in your meals or activity, or when combined with other blood-sugar-lowering medicines. Learn the signs of low blood sugar and how to treat them. Low potassium (hypokalemia) can also occur and, though uncommon, can be serious. Allergic reactions, including rare severe reactions, are possible. When Tresiba is used with certain diabetes pills called thiazolidinediones (TZDs), fluid retention and heart failure can occur.
Never share pens or needles with another person, even with a new needle, because of the risk of passing on bloodborne infections. Do not dilute Tresiba, do not transfer it from the pen or vial into a separate syringe, and do not mix it with other insulins, as this can lead to serious dosing errors. Because Tresiba comes in two concentrations (U-100 and U-200), pay close attention to which strength you have. This information is not medical advice. Talk with your doctor or pharmacist about your dose, your monitoring plan, and any questions about side effects.
This Tresiba information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Tresiba on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.