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Xdemvy

Xdemvy 10ML of 0.25%

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What is Xdemvy?

Xdemvy is an eye drop solution used to treat certain eye conditions. It helps relieve symptoms associated with these conditions, improving comfort and vision.

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What is Xdemvy ?

Xdemvy is an eye drop solution used to treat certain eye conditions. It helps relieve symptoms associated with these conditions, improving comfort and vision.

Source: MedlinePlus, U.S. National Library of Medicine

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision, tearing
  • Burning, stinging, or irritation of the eye
  • Swelling, redness, pain, or tenderness of the eyelid
  • Tell your doctor if you are pregnant or breastfeeding.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is Xdemvy used to treat?
Xdemvy (lotilaner ophthalmic solution) is FDA-approved to treat Demodex blepharitis in adults, an inflammation of the eyelids caused by an infestation of Demodex mites. It is the first and only FDA-approved therapy that directly targets these mites. It is used as one drop in each eye twice a day for 6 weeks.
How long does it take for Xdemvy to work?
Xdemvy is prescribed as a full 6-week course, one drop in each eye twice daily. Complete the entire course as directed even if your eyes feel better sooner. Your eye-care provider can tell you what improvement to expect and when to follow up.
How much does Xdemvy cost without insurance?
As a newer brand-name drug with no generic, Xdemvy can be expensive when paid in cash. Prices vary by pharmacy and location. Enter your ZIP code above to see today's Rx.com cash price near you, and compare it against your insurance and the manufacturer's savings program.
Is there a generic version of Xdemvy available?
No. There is currently no FDA-approved generic version of Xdemvy (lotilaner ophthalmic solution) marketed in the United States. Because only the brand is available, comparing a cash coupon, your insurance, and the manufacturer's savings program is the best way to lower your cost.
What are the side effects of Xdemvy eye drops?
The most common side effect is stinging or burning where the drop is placed, reported by about 1 in 10 people. Xdemvy has no boxed warning. To avoid contamination, do not touch the dropper tip to your eye or other surfaces. Talk to your doctor about any side effects that concern you.
How much does Xdemvy cost without insurance?
The price of Xdemvy without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Xdemvy?
Common side effects of Xdemvy may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blurred vision, tearing, Burning, stinging, or irritation of the eye, Swelling, redness, pain, or tenderness of the eyelid. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Xdemvy?
Generic versions may be available for Xdemvy. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Xdemvy on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Xdemvy?
The cheapest pharmacy for Xdemvy depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Xdemvy near you.

Xdemvy Coupons & Prices

Xdemvy 10ML of 0.25%

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Xdemvy Bottle — prescription drug image
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Xdemvy 10ml of 0.25% (1)
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Looking for an Xdemvy coupon? Xdemvy (lotilaner ophthalmic solution) is a prescription eye drop and the first and only FDA-approved treatment that directly targets the Demodex mites behind Demodex blepharitis, an inflammation of the eyelids in adults. There is no generic version yet, so it can be costly without help. Enter your ZIP code above to see today's Rx.com cash price at pharmacies near you, and compare it against your insurance and the manufacturer's savings program below.

What is Xdemvy and how does it work?

Xdemvy is the brand name for lotilaner ophthalmic solution, an antiparasitic eye drop. It belongs to a drug class that works as a GABA-gated chloride channel inhibitor, which paralyzes and kills Demodex mites. It is FDA-approved to treat Demodex blepharitis, the eyelid inflammation caused by an infestation of these tiny mites, in adults. Xdemvy is the first and only FDA-approved therapy that directly targets the mites themselves rather than only easing symptoms.

The usual dose is one drop in each eye twice a day for 6 weeks. If you wear contact lenses, take them out before using the drops and wait 15 minutes before putting them back in. This page is educational and not a substitute for your doctor's or pharmacist's advice.

Xdemvy cost, coupons, and the manufacturer savings card

Because Xdemvy is a newer brand-name drug with no generic, the cash price can be high. There are two main ways to save, and the right one depends on your coverage:

  • Manufacturer savings card: Tarsus Pharmaceuticals runs an official Xdemvy savings program, described on the manufacturer's website (xdemvy.com). Like most drug-maker copay cards, it is generally limited to people with commercial (private) insurance and is not available if you have Medicare, Medicaid, or other government coverage. Eligibility and terms vary, so read the program's current terms and conditions.
  • Rx.com cash coupon: Our free coupon is a cash-price discount, not insurance. It can help if you are uninsured, have Medicare or other government coverage that excludes you from the manufacturer card, or if the savings card is declined at the pharmacy. Enter your ZIP code above to see today's price at pharmacies near you.

You cannot combine a manufacturer copay card with our cash coupon on the same fill, but it is worth comparing both. If cost is still a barrier, ask your doctor's office whether Tarsus offers any patient-assistance help for those who qualify.

Xdemvy vs. other prescription eye drops

Xdemvy is unique because it treats Demodex blepharitis specifically by killing the mites. It is not a dry-eye drug. If your eye condition is chronic dry eye rather than Demodex blepharitis, your doctor may discuss different prescription options, such as Restasis (cyclosporine), Cequa (cyclosporine), or Xiidra (lifitegrast). These target inflammation associated with dry eye disease and are not interchangeable with Xdemvy.

Only a qualified eye-care provider can diagnose the cause of your eyelid or eye symptoms and choose the right treatment. Use the links above to compare prices on these related medications.

Safety and side effects

Xdemvy has no boxed warning. The most common side effect reported in studies was stinging or burning at the site where the drop is placed, which affected about 1 in 10 people. To keep the bottle from getting contaminated, do not let the dropper tip touch your eye or any other surface.

Remove contact lenses before each dose and wait 15 minutes before reinserting them. Xdemvy's safety and effectiveness have not been established in children. As always, tell your doctor about your full medical history and any other eye drops you use, and follow the directions on your prescription. This is general information, not medical advice.

Sources & accuracy

This Xdemvy information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Xdemvy on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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