Divalproex Sodium Er
Divalproex Sodium ER 500MG
What is Divalproex Sodium Er?
Depakote ER is used to help treat convulsions. The generic version of Depakote ER is Divalproex Sodium. On average Depakote ER is priced at about $446 for a supply of 60, 500 mg tablets, extended-release. You can use our Rx.com savings offer to get an average Depakote ER discount of up to 80% off of the retail price at participating pharmacies near you.Side Effects
- nausea
- drowsiness
- dizziness
Warnings
- may cause liver damage
- risk of pancreatitis
- can cause serious birth defects
- may increase suicidal thoughts or actions
- potential for serious skin reactions
Prescription savings · · · ·
What is Divalproex Sodium Er ?
Depakote ER is used to help treat convulsions. The generic version of Depakote ER is Divalproex Sodium. On average Depakote ER is priced at about $446 for a supply of 60, 500 mg tablets, extended-release. You can use our Rx.com savings offer to get an average Depakote ER discount of up to 80% off of the retail price at participating pharmacies near you.- nausea
- drowsiness
- dizziness
- vomiting
- weakness
- tremor
- hair loss
- weight gain
- blurred or double vision
- may cause liver damage
- risk of pancreatitis
- can cause serious birth defects
- may increase suicidal thoughts or actions
- potential for serious skin reactions
- monitor blood count and liver function regularly
- may interact with other medications
Divalproex Sodium Er Coupons & Prices
Divalproex Sodium ER 500MG
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Looking for a Depakote ER coupon? Depakote ER (divalproex sodium, extended-release) is a brand-name valproate medicine used as a mood stabilizer for bipolar mania, to help prevent migraine headaches, and to treat certain types of seizures. Whether you have insurance, Medicare, or no coverage at all, you can use a free Rx.com cash coupon at the pharmacy counter. Enter your ZIP above to see today's price on both the brand and its lower-cost generic in your area.
What is Depakote ER and how does it work?
Depakote ER is the extended-release form of divalproex sodium, a valproate medicine that belongs to the anticonvulsant (anti-epileptic) family and also acts as a mood stabilizer. It is FDA-approved for the acute treatment of manic or mixed episodes of bipolar disorder (with or without psychotic features), for the prevention (prophylaxis) of migraine headaches, and for treating complex partial seizures as well as simple and complex absence seizures in patients 10 years and older, either on its own or added to other therapy.
The "ER" means the tablet releases the medicine slowly over the day, which usually allows once-daily dosing. Valproate is thought to work by increasing the calming brain chemical GABA and steadying overactive electrical signaling in the brain. Depakote ER is also sometimes prescribed off-label for other conditions; only your prescriber can decide whether it is right for you.
Depakote ER cost: manufacturer savings vs. the Rx.com cash coupon
The good news for cost is that Depakote ER has an FDA-approved generic, divalproex sodium extended-release, and the generic is typically the single biggest way to lower your bill. There is no widely available manufacturer copay card for Depakote ER, and any drugmaker copay card would generally require commercial (non-government) insurance anyway. AbbVie, the maker of Depakote, does run a patient assistance program through the AbbVie Patient Assistance Foundation for qualifying patients with limited income; you can look up that program on AbbVie's official website, and terms and eligibility vary.
An Rx.com cash coupon works differently: it is a discount you use instead of insurance, so it can help if you are uninsured, on Medicare (where copay cards are not allowed), or if a card is declined. Ask your pharmacist to run the Rx.com price and compare it against your insurance copay and the generic price, then use whichever is lower. Enter your ZIP above to see today's price at pharmacies near you.
Depakote ER vs. Depakote DR and other alternatives
Depakote comes in more than one form. Depakote (the delayed-release, or DR, tablet) and Depakote ER (extended-release) are not interchangeable milligram-for-milligram, so never switch between them without your prescriber's guidance. Both deliver the same active valproate ingredient but are absorbed differently, which affects dosing. Depakene and valproic acid are closely related valproate products.
Depending on the condition, a prescriber may consider other options. For seizures and mood stabilization, lamotrigine is a common alternative, and topiramate is used both for certain seizures and for migraine prevention. This is background information, not a recommendation; the right choice depends on your diagnosis and health history.
Important safety information
Depakote ER carries an FDA boxed warning for three serious risks. First, hepatotoxicity, including rare but sometimes fatal liver failure that most often occurs within the first six months; children under 2 and people with mitochondrial disorders (such as POLG mutations) are at highest risk. Second, fetal risk: valproate can cause major birth defects, including neural tube defects (spina bifida), and lower IQ in children exposed before birth. It is contraindicated for migraine prevention in pregnancy and should not be used in women who can become pregnant unless clearly essential. Third, pancreatitis, including rare fatal cases.
Depakote ER is also contraindicated in people with urea cycle disorders and known mitochondrial disease, and it can cause high blood ammonia with confusion (hyperammonemic encephalopathy), low platelet counts, and suicidal thoughts. Doctors monitor liver function, blood counts and platelets, and ammonia during treatment. This is not medical advice; take Depakote ER exactly as prescribed, keep your lab appointments, and talk with your doctor or pharmacist about your personal risks before starting or stopping.
This Divalproex Sodium Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Divalproex Sodium Er on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.