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Levetiracetam Er Tablet Extended Release 24 Hour — prescription drug image

Levetiracetam Er

levETIRAcetam ER 500MG

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What is Levetiracetam Er?

Levetiracetam ER is prescribed to patients to prevent the symptoms of seizures and epilepsy. Levetiracetam ER is a generic drug. The average Levetiracetam ER price is about $45 for a supply of 60, 500 mg oral tablets, extended release. You can use our Rx.com savings offer to get a Levetiracetam ER discount of up to 80% off of the retail price at participating pharmacies near you.

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What is Levetiracetam Er ?

Levetiracetam ER is prescribed to patients to prevent the symptoms of seizures and epilepsy. Levetiracetam ER is a generic drug. The average Levetiracetam ER price is about $45 for a supply of 60, 500 mg oral tablets, extended release. You can use our Rx.com savings offer to get a Levetiracetam ER discount of up to 80% off of the retail price at participating pharmacies near you.
  • Unusual bleeding or bruising
  • Fever, chills, cough, sore throat, body aches
  • Unusual changes in mood or behavior, depression, thoughts of hurting yourself
  • Problems with balance, coordination, or walking
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Extreme sleepiness, tiredness, or weakness
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, high blood pressure, or a history of depression or mental health problems.
  • This medicine may cause the following problems:Unusual changes in mood or behaviorSerious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysisProblems with muscle control and coordinationHigh blood pressure
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • This medicine may make you dizzy, drowsy, or clumsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. Your seizures may return or occur more often if you stop using this medicine suddenly.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
What is levetiracetam ER used for?
Levetiracetam extended-release is FDA-approved to treat partial-onset (focal) seizures in adults and children 12 years of age and older. The extended-release tablet is taken once daily. It is the generic form of Keppra XR.
What is the difference between levetiracetam and levetiracetam ER (extended-release)?
They contain the same active medicine. Standard (immediate-release) levetiracetam is usually taken twice a day, while the extended-release (ER) form releases the medicine slowly so it can be taken just once a day. Some of the broader levetiracetam seizure approvals apply specifically to the immediate-release product, so your prescriber chooses the form that fits your diagnosis and schedule.
What are the most common side effects of levetiracetam extended-release?
The most common side effects are sleepiness, dizziness, and tiredness, particularly during the first four weeks. Some people also have coordination difficulties. Behavior and mood changes such as irritability or aggression can also occur. Contact your provider if side effects are bothersome or do not go away.
Can levetiracetam ER cause mood changes or depression?
Yes. Levetiracetam can cause psychiatric and behavioral reactions, including irritability, aggression, agitation, anxiety, and depression, and rarely psychotic symptoms. Like all antiseizure medicines, it also carries a small risk of suicidal thoughts or behavior. Tell your healthcare provider right away about any new or worsening mood changes.
Is levetiracetam ER a controlled substance?
No. Levetiracetam extended-release is not a controlled substance and has no DEA schedule. It does still require a prescription from your healthcare provider.
How much does Levetiracetam Er cost without insurance?
The price of Levetiracetam Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Levetiracetam Er?
Common side effects of Levetiracetam Er may include: Unusual bleeding or bruising, Fever, chills, cough, sore throat, body aches, Unusual changes in mood or behavior, depression, thoughts of hurting yourself, Problems with balance, coordination, or walking, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Levetiracetam Er?
Generic versions may be available for Levetiracetam Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Levetiracetam Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Levetiracetam Er?
The cheapest pharmacy for Levetiracetam Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Levetiracetam Er near you.

Levetiracetam Er Coupons & Prices

levETIRAcetam ER 500MG

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Levetiracetam Er Tablet Extended Release 24 Hour — prescription drug image
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Looking for a levetiracetam ER coupon? Levetiracetam extended-release is the generic form of Keppra XR, a once-daily antiseizure medicine, and because it is a widely stocked generic the cash price is usually low to begin with. Even so, the price you pay can vary a lot from one pharmacy to the next, so it pays to compare. Rx.com checks prices across more than 60,000 U.S. pharmacies so you can find today's best cash price near you. Enter your ZIP above to see today's price and print or text yourself a free discount coupon.

What is levetiracetam ER and how does it work?

Levetiracetam extended-release is an antiepileptic (anticonvulsant) medicine. It is the generic version of Keppra XR. It is FDA-approved to treat partial-onset (focal) seizures in adults and children 12 years of age and older. The extended-release tablet is designed to release the medicine slowly, which allows convenient once-daily dosing (a typical range is 1000 to 3000 mg once daily).

Levetiracetam works differently from many older seizure drugs. It binds to a brain protein called SV2A (a synaptic vesicle protein), which is thought to help calm the abnormal, excessive electrical activity that causes seizures. It does not need to be adjusted for most drug interactions, but the dose does need to be lowered for people with reduced kidney function.

Cost of levetiracetam ER without insurance

Levetiracetam ER is available as an FDA-approved generic, so it is generally one of the more affordable seizure medicines even if you pay cash. There is no brand manufacturer savings card for the generic. That said, pharmacies set their own cash prices, and the difference between two stores in the same town can be surprisingly large. Comparing before you fill is the single easiest way to avoid overpaying.

Rx.com compares cash prices across more than 60,000 pharmacies nationwide and gives you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you. The coupon is free to use and there is no membership required.

Levetiracetam ER vs. related seizure medicines

Levetiracetam comes in two main forms: the standard immediate-release levetiracetam, usually taken twice a day, and the extended-release form on this page, taken once a day. Some of the broader levetiracetam approvals (such as certain myoclonic and generalized tonic-clonic seizure uses) are formally approved for the immediate-release product rather than the ER tablet, so your prescriber chooses the form that fits your diagnosis.

If levetiracetam is not the right fit, other commonly prescribed antiseizure medicines your provider may discuss include lamotrigine, oxcarbazepine, and topiramate. Each works differently and has its own side-effect profile. Only your healthcare provider can decide which is appropriate for you, and you can compare prices on any of them with Rx.com.

Safety and side effects

Levetiracetam ER has no boxed warning. The most common side effects, especially in the first four weeks, are sleepiness (somnolence), dizziness, and fatigue, and some people have coordination difficulties. The most important thing to watch for is mood or behavior changes: levetiracetam can cause irritability, aggression, agitation, anxiety, or depression, and rarely psychotic symptoms. Like all antiepileptic drugs, it also carries a small class-wide risk of suicidal thoughts or behavior. Tell your provider promptly about any new or worsening mood changes.

Rare but serious reactions include severe allergic reactions (anaphylaxis or angioedema), serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, and DRESS), and changes in blood cell counts. Do not stop levetiracetam suddenly, since abruptly stopping can increase seizures; your provider will taper the dose if you need to come off it. This page is general information and not medical advice, so talk with your provider or pharmacist about your specific situation.

Sources & accuracy

This Levetiracetam Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Levetiracetam Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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