What is Methotrexate (Anti-Rheumatic)?

Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat rheumatoid arthritis by reducing inflammation and slowing disease progression. It works by inhibiting the enzyme dihydrofolate reductase, thereby obstructing folate pathways which are critical for the synthesis of DNA and cell replication. Methotrexate is also employed in lower doses to manage other autoimmune conditions and in higher doses for certain types of cancer treatment.

Side Effects

• Change in how much or how often you urinate, lower back or side pain
• Fever, chills, cough, sore throat, body aches
• Chest pain, trouble breathing, blue lips or fingers

Warnings

• Keep all medicine out of the reach of children. Never share your medicine with anyone.
• This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Female patients should use an effective form of birth control during treatment and for at least 3 or 6 months after the last dose. Male patients who have female partners should use an effective form of birth control during treatment and for at least 3 months after the last dose.
• Do not breastfeed during treatment and for at least 1 week after the last dose.
• Tell your doctor if you have kidney disease, liver disease, blood or bone marrow problems (including anemia), diabetes, a weak immune system, any type of infection, stomach or bowel problem (including ulcers), lung or breathing problem, or a history of alcohol abuse.
• This medicine may cause the following problems:Serious infections, which may be life-threateningKidney problemsStomach or bowel problems, including ulcer or perforationLiver problemsLung or breathing problems, including acute or chronic interstitial pneumonitisSerious skin reactions, including toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, skin necrosis, or erythema multiformeIncreased risk of other cancers, including blood or skin cancerNerve problemsTumor lysis syndrome (electrolyte and metabolic problem that can be life-threatening)