Zolpidem Tartrate Er
Zolpidem Tartrate ER 12.5MG
What is Zolpidem Tartrate Er?
Ambien CR (zolpidem extended-release) is a prescription sleep medication used to treat insomnia in adults who have difficulty falling asleep or staying asleep. Its dual-layer extended-release formulation helps you fall asleep faster while providing longer-lasting sleep throughout the night.
Side Effects
- Changes in mood or behavior, depression, nervousness, thoughts or attempts of hurting yourself
- Unusual tiredness or weakness
- Seeing, hearing, or feeling things that are not there
Warnings
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Call your doctor if you still have trouble sleeping after you take this medicine for 7 to 10 days.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may cause dizziness, drowsiness, especially first thing the next morning. It may also cause decreased alertness or trouble with thinking or trouble with controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Prescription savings · · · ·
What is Zolpidem Tartrate Er ?
Ambien CR (zolpidem extended-release) is a prescription sleep medication used to treat insomnia in adults who have difficulty falling asleep or staying asleep. Its dual-layer extended-release formulation helps you fall asleep faster while providing longer-lasting sleep throughout the night.
- Changes in mood or behavior, depression, nervousness, thoughts or attempts of hurting yourself
- Unusual tiredness or weakness
- Seeing, hearing, or feeling things that are not there
- Severe confusion, drowsiness, muscle weakness
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blue lips, fingernails, or skin, trouble breathing, chest pain
- Memory loss
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Call your doctor if you still have trouble sleeping after you take this medicine for 7 to 10 days.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may cause dizziness, drowsiness, especially first thing the next morning. It may also cause decreased alertness or trouble with thinking or trouble with controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Using this medicine during the last 3 months of your pregnancy (third trimester) can harm your newborn baby. Tell your doctor right away if you are pregnant or if you think you have become pregnant while using this medicine.
- This medicine may cause the following problems:Sleep-related behaviors (including sleep-driving, sleep-walking, or having sex, making phone calls, or preparing and eating food while you are asleep or not fully awake)Unusual thoughts or behaviorRespiratory depression (serious breathing problem that can be life-threatening), when used with narcotic pain medicines
- Tell your doctor if you have kidney disease, liver disease, lung disease (including COPD), breathing problems (including sleep apnea), or myasthenia gravis. Tell your doctor if you have a history of alcohol or drug addiction, depression, or mental health problems.
- Do not breastfeed while you are using this medicine. You should pump and throw away breast milk for 23 hours after using this medicine.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
Zolpidem Tartrate Er Coupons & Prices
Zolpidem Tartrate ER 12.5MG
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Zolpidem Tartrate Er prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 6.25mg · Tablet Extended Release | 30 | $153.99 | $14.69 |
| 12.5mg · Tablet Extended Release | 30 | $150.49 | $23.82 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a zolpidem tartrate ER coupon? Zolpidem tartrate extended-release is the generic form of Ambien CR, a sedative-hypnotic "Z-drug" used for the short-term treatment of insomnia. Because it is a generic, it is already one of the more affordable sleep medications, but the cash price can vary widely from one pharmacy to the next. Rx.com compares prices across more than 60,000 pharmacies so you can find a lower price near you. Enter your ZIP above to see today's price and print or show your free coupon at the pharmacy counter.
What is zolpidem tartrate ER and how does it work?
Zolpidem tartrate extended-release (ER, also written as CR) is a nonbenzodiazepine sedative-hypnotic, part of the group commonly called "Z-drugs." It works on GABA-A receptors in the brain to help calm activity and bring on sleep. It is FDA-approved for the short-term treatment of insomnia in adults who have trouble falling asleep, staying asleep, or both.
The extended-release tablet uses a two-layer design: the first layer dissolves quickly to help you fall asleep, and the second layer releases slowly through the night to help you stay asleep. This is what sets the ER version apart from standard, immediate-release zolpidem, which is aimed mainly at helping you fall asleep.
Cost of zolpidem tartrate ER without insurance
As a generic, zolpidem tartrate ER is generally low-cost, but there is no single "list price." What you pay in cash can differ a lot depending on the pharmacy you choose, your dose, and your location. That is exactly why comparing prices matters. Rx.com checks the cash price across more than 60,000 U.S. pharmacies and shows you a free discount coupon you can use whether or not you have insurance.
To see what zolpidem tartrate ER costs near you today, enter your ZIP code above. If your provider has prescribed the brand version, you can also compare against Ambien CR to see which is the better value for you.
Alternatives and related sleep medications
Zolpidem tartrate ER is one of several prescription options for insomnia. Your provider decides which is right for you, but it can help to know the alternatives when comparing prices:
- Zolpidem — the immediate-release form, focused on helping you fall asleep
- Ambien and Ambien CR — the brand-name versions of zolpidem
- Eszopiclone and Zaleplon — other nonbenzodiazepine "Z-drug" sleep aids
- Temazepam — a benzodiazepine sometimes used for insomnia
- Trazodone — an antidepressant often prescribed off-label to help with sleep
Enter your ZIP above to compare coupon prices on these medications side by side.
Important safety information
Zolpidem tartrate ER carries a boxed warning for complex sleep behaviors — such as sleep-walking, sleep-driving, and preparing or eating food, making phone calls, or having sex while not fully awake. These behaviors can cause serious injury or death, and the drug should not be used by anyone who has had such an episode. Do not take it with alcohol or other medicines that slow the central nervous system. Because the ER form can cause next-day drowsiness and slower reaction time (a risk that can be higher in women), do not drive or operate machinery the day after taking it unless you are fully awake.
This medicine is a Schedule IV controlled substance and can lead to abuse, dependence, and withdrawal. It may also cause abnormal thinking or behavior, worsening depression, or suicidal thoughts, and calls for caution in older adults (fall risk), in people with breathing or liver problems, and during pregnancy. This information is not medical advice — talk with your doctor or pharmacist about whether zolpidem tartrate ER is right for you.
This Zolpidem Tartrate Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Zolpidem Tartrate Er on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.