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Adapalene-Benzoyl Peroxide Pump Btl — prescription drug image

Adapalene-Benzoyl Peroxide

Adapalene-Benzoyl Peroxide 45GM of 0.1-2.5%

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What is Adapalene-Benzoyl Peroxide?

Adapalene-Benzoyl Peroxide is a topical acne agent used to treat severe acne. Adapalene-Benzoyl Peroxide is a generic drug. You can use our Rx.com Adapalene-Benzoyl Peroxide savings card to save significantly on the retail price at participating pharmacies near you.

Prescription savings · · · ·

What is Adapalene-Benzoyl Peroxide ?

Adapalene-Benzoyl Peroxide is a topical acne agent used to treat severe acne. Adapalene-Benzoyl Peroxide is a generic drug. You can use our Rx.com Adapalene-Benzoyl Peroxide savings card to save significantly on the retail price at participating pharmacies near you.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Severe redness or swelling of the skin
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined. Do not use this medicine if you have a sunburn or eczema.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • You may need to use this medicine for several weeks or months before your skin starts to look better.
  • Allow this medicine to dry completely before you get dressed. This medicine may cause bleaching of clothes or hair.
  • Tell your doctor if you are pregnant or breastfeeding.
  • This medicine may make your skin more sensitive to sunlight, wind, and cold weather. Use sunscreen when you are outdoors, and wear protective clothing, such as a hat. Do not use a sunlamp or tanning bed.
  • Use a moisturizer as needed if your skin becomes irritated.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Do not use waxing as a hair removal method on skin areas treated with this medicine.
What is adapalene-benzoyl peroxide gel used for?
It is an FDA-approved topical treatment for acne vulgaris. It combines adapalene, a retinoid that normalizes skin-cell turnover and reduces inflammation, with benzoyl peroxide, which kills acne-causing bacteria and helps clear pores. It is applied as a thin film once daily to affected areas.
How long does it take for adapalene and benzoyl peroxide to clear acne?
Topical acne treatments generally take several weeks of consistent daily use before you see improvement, and skin irritation is often worst in the first few weeks. Keep using it as directed and give it time. Ask your provider how long to expect for your situation and when to follow up if you do not see results.
Is adapalene-benzoyl peroxide the same as Epiduo?
Yes. Epiduo (0.1%/2.5%) and Epiduo Forte (0.3%/2.5%) are the brand names for the adapalene / benzoyl peroxide combination gel. The generic contains the same active ingredients and typically costs less than the brand.
Can you use adapalene-benzoyl peroxide gel every day?
Yes, it is designed to be applied once daily as a thin film to affected areas, following your prescriber's directions for your strength. Because it can cause dryness and irritation early on, follow the instructions you were given and check with your provider if the irritation is severe.
Does adapalene-benzoyl peroxide come in a generic, and is it cheaper than Epiduo?
Yes, a generic version is available and it is usually much cheaper than the Epiduo and Epiduo Forte brands. Cash prices still vary by pharmacy, so it helps to compare. Enter your ZIP on Rx.com to see today's price near you and get a free discount coupon.
How much does Adapalene-Benzoyl Peroxide cost without insurance?
The price of Adapalene-Benzoyl Peroxide without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 63% off retail prices with a free Rx.com coupon.
What are the common side effects of Adapalene-Benzoyl Peroxide?
Common side effects of Adapalene-Benzoyl Peroxide may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Severe redness or swelling of the skin, Blistering, burning, crusting, dryness, or flaking of the skin. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Adapalene-Benzoyl Peroxide?
Generic versions may be available for Adapalene-Benzoyl Peroxide. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Adapalene-Benzoyl Peroxide on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Adapalene-Benzoyl Peroxide?
The cheapest pharmacy for Adapalene-Benzoyl Peroxide depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Adapalene-Benzoyl Peroxide near you.

Adapalene-Benzoyl Peroxide Coupons & Prices

Adapalene-Benzoyl Peroxide 45GM of 0.1-2.5%

Skin Care
Licensed US providers · Online visit in minutes
Adapalene-Benzoyl Peroxide Pump Btl — prescription drug image
Prescription
Adapalene-Benzoyl Peroxide 45gm of 0.1-2.5% (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for an adapalene-benzoyl-peroxide coupon? This once-daily topical acne gel is the generic form of Epiduo and Epiduo Forte, and because it is a generic it already tends to cost far less than the brand. Cash prices still vary widely from one pharmacy to the next, so it pays to compare. Rx.com checks prices across more than 60,000 pharmacies so you can find today's lowest cost near you. Enter your ZIP above to see today's price and print or text yourself a free discount coupon.

What is adapalene-benzoyl peroxide and how does it work?

Adapalene / benzoyl peroxide is a combination gel FDA-approved for the topical treatment of acne vulgaris. It pairs two acne fighters in one product: adapalene, a retinoid that helps normalize skin-cell turnover and reduce inflammation, and benzoyl peroxide, which kills acne-causing bacteria (Cutibacterium acnes) and helps clear clogged pores. It is the generic equivalent of the brands Differin-family products marketed as Epiduo and Epiduo Forte.

The 0.1%/2.5% strength (Epiduo) is approved for patients 9 years and older, and the stronger 0.3%/2.5% strength (Epiduo Forte) is approved for patients 12 and older. It is applied as a thin film once daily to the affected areas of clean, dry skin. Follow your prescriber's or pharmacist's directions for the strength you were given.

How much does adapalene-benzoyl peroxide cost without insurance?

Because a generic version is available, adapalene / benzoyl peroxide is usually much cheaper than the Epiduo or Epiduo Forte brand. Even so, the cash price without insurance can differ a lot depending on which pharmacy you use and which strength you were prescribed, so comparing before you fill matters. Rx.com compares prices across more than 60,000 U.S. pharmacies and gives you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you.

If you were prescribed the brand, the manufacturer (Galderma) offers a savings program on its official Epiduo Forte website; program terms and eligibility vary and can change, so check the manufacturer's site for current details. For the generic, the Rx.com discount price is often the simplest way to keep costs down at the counter.

Alternatives and related acne treatments

Adapalene / benzoyl peroxide combines two ingredients, but each is also available on its own, and other prescription acne options work in similar ways. Depending on your skin and what your provider recommends, related treatments include:

  • adapalene — the retinoid used alone
  • benzoyl peroxide — the antibacterial ingredient used alone
  • tretinoin — another topical retinoid
  • tazarotene — a topical retinoid
  • clindamycin / benzoyl peroxide — an antibiotic-plus-benzoyl-peroxide combination

Which option is right for you depends on your acne and medical history. This is general information, not medical advice, so talk with your provider or pharmacist before switching products. Whichever you fill, you can compare its price on Rx.com.

Safety and side effects

Adapalene / benzoyl peroxide has no boxed warning. It is for external use only — avoid contact with the eyes, lips, mouth, and other mucous membranes, and do not apply it to skin that is cut, scraped, sunburned, or affected by eczema. The most common effects are local skin irritation: dryness, redness, scaling, and stinging or burning, plus possible contact dermatitis. These are usually worst during the first few weeks and often ease as your skin adjusts.

Two practical cautions: benzoyl peroxide can bleach hair and dyed fabrics, so let it dry and be careful around towels and pillowcases; and this medicine can make your skin more sensitive to the sun, so limit UV exposure and use sunscreen. Rare but serious allergic reactions have been reported — stop use and get medical care right away if you notice swelling, hives, or trouble breathing. This is general information and not a substitute for your prescriber's advice, so follow the product directions and ask your provider or pharmacist with any questions.

Sources & accuracy

This Adapalene-Benzoyl Peroxide information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Adapalene-Benzoyl Peroxide on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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