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Adapalene

Adapalene 45GM of 0.3%

Skin Care
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What is Adapalene?

Adapalene is a third-generation topical retinoid primarily used in the treatment of mild to moderate acne and is also used for keratosis pilaris. It works by modulating skin cell growth and differentiation, providing anti-inflammatory effects, and aiding in the reduction of comedones (blackheads and whiteheads). Adapalene is available in various formulations such as gels, creams, and lotions.

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What is Adapalene ?

Adapalene is a third-generation topical retinoid primarily used in the treatment of mild to moderate acne and is also used for keratosis pilaris. It works by modulating skin cell growth and differentiation, providing anti-inflammatory effects, and aiding in the reduction of comedones (blackheads and whiteheads). Adapalene is available in various formulations such as gels, creams, and lotions.
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Severe skin redness or swelling
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • At first, your acne may seem to get worse before it gets better. Keep using the medicine as directed.
  • Tell your doctor if you are pregnant or breastfeeding, or if you are sensitive to sunlight or have eczema.
  • Use a moisturizer as needed if your skin becomes irritated.
  • This medicine may make your skin more sensitive to sunlight, wind, and cold weather. Use sunscreen when you are outdoors, and wear protective clothing, such as a hat. Do not use a sunlamp or tanning bed.
  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined. Do not use this medicine on skin that is sunburned or has active eczema.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
What is adapalene used for?
Adapalene is FDA-approved to treat acne vulgaris in people 12 years and older. It is a topical retinoid that helps skin cells turn over normally and reduces inflammation, which keeps clogged pores and pimples from forming. It comes as a gel, cream, lotion, solution, and pledgets.
How long does adapalene take to work for acne?
You may see some early improvement within a few weeks, but full benefit typically takes about 8 to 12 weeks of regular use. Skin can look worse or feel irritated during the first 2 to 4 weeks as it adjusts, so it helps to be patient and consistent.
Is adapalene the same as Differin?
Yes. Differin is a brand name for adapalene, so they are the same active medicine. The 0.1% gel is sold over the counter as Differin Gel, while other strengths and formulations may require a prescription. Generic adapalene is available and is often less expensive.
Can you use adapalene every day, and should it be applied at night?
Adapalene is generally applied once a day as directed by your clinician, and many people apply it at night because it can increase sensitivity to sunlight. Follow the directions on your prescription or product label, and always use sunscreen during the day. Ask your doctor or pharmacist if you are unsure how to use it.
What are the most common side effects of adapalene?
The most common effects are local skin reactions, especially in the first 2 to 4 weeks: redness, dryness, scaling, burning, and stinging. Adapalene also increases sun sensitivity. Rarely, a serious allergic reaction such as hives, facial or throat swelling, or trouble breathing can occur and requires emergency care.
How much does Adapalene cost without insurance?
The price of Adapalene without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Adapalene?
Common side effects of Adapalene may include: Blistering, burning, crusting, dryness, or flaking of the skin, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Severe skin redness or swelling. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Adapalene?
Generic versions may be available for Adapalene. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Adapalene on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Adapalene?
The cheapest pharmacy for Adapalene depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Adapalene near you.

Adapalene Coupons & Prices

Adapalene 45GM of 0.3%

Skin Care
Licensed US providers · Online visit in minutes
Adapalene Tube Of Gel — prescription drug image
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Adapalene 45gm of 0.3% (1)
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Looking for an adapalene coupon? Adapalene is a widely used generic topical retinoid for acne, and because it is generic it is already one of the more affordable acne prescriptions. Even so, the cash price can vary a lot from one pharmacy to the next, which is exactly why comparing pays off. Rx.com checks prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see the current price on adapalene and print or text yourself a free discount coupon.

What is adapalene and how does it work?

Adapalene is a topical retinoid (a third-generation, retinoid-like compound) that is FDA-approved to treat acne vulgaris in people 12 years and older. It works by helping skin cells turn over normally and by calming inflammation, which stops clogged pores and pimples (comedones) from forming beneath the surface of the skin. It comes in several forms, including gel, cream, lotion, solution, and pledgets, in 0.1% and 0.3% strengths.

The 0.1% gel (branded as Differin Gel) is also sold over the counter, so some strengths are available without a prescription while stronger versions and other formulations require one. Adapalene is also a component of the combination products Epiduo and Epiduo Forte, which pair it with benzoyl peroxide.

Adapalene cost and how to save without insurance

Adapalene is available as a generic, which typically keeps its price lower than brand-name acne treatments. But "generic" does not mean the price is the same everywhere. The cash price without insurance can differ widely depending on the pharmacy, the strength, and the formulation you are prescribed, so it is worth comparing before you fill. A free Rx.com discount coupon can be used at the pharmacy counter whether or not you have insurance, and you do not need to enroll in a program to use it.

To see what adapalene costs near you, enter your ZIP above. Rx.com compares live prices across more than 60,000 pharmacies and shows today's price so you can pick the lowest one. Because there is no manufacturer savings card for generic adapalene, comparison shopping is the most reliable way to lower your out-of-pocket cost.

Adapalene vs. Differin and other acne treatments

Differin is a brand name for adapalene, so the two are the same medicine. Generic adapalene is available in prescription strengths and formulations, and the 0.1% gel is sold over the counter as Differin Gel. If your prescription is written for the brand, you can compare it against the generic to see which costs less at your pharmacy. View the Differin page to compare directly.

Adapalene is one of several topical treatments used for acne. Other retinoids include tretinoin and tazarotene. Many people are also prescribed benzoyl peroxide or topical clindamycin, and adapalene is combined with benzoyl peroxide in Epiduo. Which option is right for you depends on your skin and your clinician's guidance, but comparing prices on each can help you keep costs down.

Safety and what to expect

Adapalene has no boxed warning. Local skin reactions are common, especially during the first 2 to 4 weeks, and can include redness, dryness, scaling, burning, and stinging as your skin adjusts. Adapalene also makes your skin more sensitive to sunlight, so use sunscreen, avoid sunlamps, and minimize sun exposure. Do not apply it to cuts, scrapes, eczema, or sunburned skin, and avoid waxing treated areas. It is for external use only, so keep it away from the eyes, lips, and other mucous membranes.

Give it time to work: full benefit can take 8 to 12 weeks. Rarely, an allergic reaction such as hives, swelling of the face or throat, or trouble breathing can occur and needs emergency care. If you are pregnant or breastfeeding, talk with your clinician before using adapalene. This information is not medical advice; ask your doctor or pharmacist about what is right for you.

Sources & accuracy

This Adapalene information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Adapalene on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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