Brenzavvy
Brenzavvy 20MG
What is Brenzavvy?
Brenzavvy (bexagliflozin) is a prescription medication used to improve blood sugar control in adults with type 2 diabetes. As an SGLT2 inhibitor, it helps the kidneys remove excess glucose through the urine, supporting lower A1C levels while also providing modest weight loss and blood pressure benefits for some patients.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate, bloody or cloudy urine, difficult or painful urination, lower back or side pain, chills
- Fast or pounding heartbeat, increased hunger, headache, confusion, shaking, trembling, sweating
Warnings
- Tell your doctor if you are pregnant. Do not use this medicine during the second and third part of your pregnancy, unless your doctor tells you to.
- Do not breastfeed during treatment with this medicine.
- Tell your doctor if you have kidney disease, liver disease, low blood pressure, blood vessel problems, nerve problems, or a history of leg surgery, or foot ulcers, or urinary or genital yeast infections. Tell your doctor if you are on a low-salt diet, if you drink alcohol, or if you are having surgery or other procedures that require fasting.
- This medicine may cause the following problems:Low blood pressureDiabetic ketoacidosis (high ketones and acid in the blood), which can be life-threateningKidney problemsIncreased risk of genital yeast or urinary tract infectionsIncreased risk for lower leg or toe amputation (removal)Low blood sugar, when used with other diabetes medicineFournier's gangrene (skin or tissue damage of the area between the anus and genitals)
- This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.
Prescription savings · · · ·
What is Brenzavvy ?
Brenzavvy (bexagliflozin) is a prescription medication used to improve blood sugar control in adults with type 2 diabetes. As an SGLT2 inhibitor, it helps the kidneys remove excess glucose through the urine, supporting lower A1C levels while also providing modest weight loss and blood pressure benefits for some patients.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate, bloody or cloudy urine, difficult or painful urination, lower back or side pain, chills
- Fast or pounding heartbeat, increased hunger, headache, confusion, shaking, trembling, sweating
- Fast or trouble breathing, stomach pain, nausea, vomiting
- Lightheadedness, dizziness, fainting
- Pain, tenderness, redness, or swelling of the area between the anus and genitals, fever, unusual tiredness or weakness
- Pain, tenderness, sores or ulcers, or infections on the leg or foot
- Tell your doctor if you are pregnant. Do not use this medicine during the second and third part of your pregnancy, unless your doctor tells you to.
- Do not breastfeed during treatment with this medicine.
- Tell your doctor if you have kidney disease, liver disease, low blood pressure, blood vessel problems, nerve problems, or a history of leg surgery, or foot ulcers, or urinary or genital yeast infections. Tell your doctor if you are on a low-salt diet, if you drink alcohol, or if you are having surgery or other procedures that require fasting.
- This medicine may cause the following problems:Low blood pressureDiabetic ketoacidosis (high ketones and acid in the blood), which can be life-threateningKidney problemsIncreased risk of genital yeast or urinary tract infectionsIncreased risk for lower leg or toe amputation (removal)Low blood sugar, when used with other diabetes medicineFournier's gangrene (skin or tissue damage of the area between the anus and genitals)
- This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Brenzavvy Coupons & Prices
Brenzavvy 20MG
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Looking for a Brenzavvy coupon? Brenzavvy (bexagliflozin) is a brand-name SGLT2 inhibitor taken once daily to help improve blood sugar control in adults with type 2 diabetes, alongside diet and exercise. There is no generic version yet, so the price can be a real concern. Rx.com offers a free cash-price coupon you can use at the pharmacy counter, even if you are uninsured, on Medicare, or if a manufacturer card is declined. Enter your ZIP above to see today's Brenzavvy price at pharmacies near you.
What is Brenzavvy and how does it work?
Brenzavvy (bexagliflozin) is an SGLT2 inhibitor, which stands for sodium-glucose co-transporter 2 inhibitor. It is FDA-approved as an addition to diet and exercise to improve blood sugar (glycemic) control in adults with type 2 diabetes mellitus. It works by helping the kidneys remove extra sugar from the body through the urine. The usual dose is 20 mg taken once daily in the morning.
Brenzavvy is not approved for type 1 diabetes and is not recommended for people with diabetic ketoacidosis. It is worth noting that, unlike some other SGLT2 inhibitors such as Jardiance (empagliflozin) and Farxiga (dapagliflozin), Brenzavvy does not currently carry FDA-approved indications for heart or kidney outcomes. Always follow your provider's guidance on how and when to take it.
Brenzavvy cost: manufacturer savings vs. Rx.com cash coupon
Brenzavvy is a brand-name drug with no generic equivalent available, which is the main reason it can be expensive. TheracosBio launched Brenzavvy at a lower list price than many competing branded SGLT2 inhibitors, and it has been offered through low-cost cash channels. Because prices change often and vary by pharmacy, enter your ZIP above to see today's Brenzavvy price near you.
Brenzavvy does not currently offer a manufacturer copay savings card the way many branded drugs do. Manufacturer copay cards, when they exist, are typically limited to people with commercial (non-government) insurance and their terms vary. The Rx.com cash coupon is different: it is free to use and works for the uninsured, for people on Medicare, or when a manufacturer card is declined. If you have insurance, it is worth comparing your insurance copay against the Rx.com cash price to see which is lower.
Brenzavvy alternatives and related SGLT2 inhibitors
Brenzavvy belongs to the same drug class as several other type 2 diabetes medications. If you and your provider are weighing options, other SGLT2 inhibitors include:
- Jardiance (empagliflozin)
- Farxiga (dapagliflozin)
- Invokana (canagliflozin)
- Steglatro (ertugliflozin)
These drugs work in a similar way but are not identical. Some carry additional FDA-approved heart or kidney benefits that Brenzavvy does not currently have, and pricing differs between them. This is not medical advice; your provider can help you choose the right medication for your situation, and you can compare cash prices for each on Rx.com.
Brenzavvy safety and side effects
Brenzavvy has no boxed warning, but like other SGLT2 inhibitors it carries several important warnings and precautions. Its FDA label lists five: diabetic ketoacidosis, lower limb amputation, volume depletion, genitourinary infections, and hypoglycemia when used with certain other diabetes medicines.
Diabetic ketoacidosis can occur even with near-normal blood sugar, so your provider may have you stop the drug before scheduled surgery. In a cardiovascular outcomes trial, an increased number of lower limb amputations (most often of the toe and midfoot) occurred in patients taking Brenzavvy compared with placebo; the risk was highest in people with a history of prior amputation, peripheral vascular disease, or neuropathy. Because of this, your provider should weigh your amputation risk factors before you start, and you should watch for and report any new leg or foot pain, tenderness, sores, ulcers, or signs of infection. Volume depletion (dehydration) and low blood pressure can lead to acute kidney injury. Genitourinary infections range from urinary tract infections that can become serious (urosepsis and pyelonephritis) to genital yeast infections, and rarely a serious infection called necrotizing fasciitis of the perineum (Fournier's gangrene), which is a medical emergency. Brenzavvy can also raise LDL cholesterol.
Low blood sugar (hypoglycemia) is more likely when Brenzavvy is combined with insulin or medicines that increase insulin, so your provider may lower those doses. Brenzavvy is not for people with type 1 diabetes and may not be effective if kidney function falls below the label threshold. This is general information, not medical advice. Talk with your doctor or pharmacist about your health and any side effects, and seek emergency care for symptoms like severe pain, swelling, or redness in the genital area.
This Brenzavvy information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Brenzavvy on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.