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Ethosuximide Capsule — prescription drug image

Ethosuximide

Ethosuximide 250MG

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What is Ethosuximide?

Zarontin is used treat epilepsy. Ethosuximide is the generic version of Zarontin. The average cost of Zarontin is approximately $394 for a supply of 100, 250 mg oral capsules. You can use our Singlecare savings offer to get an average Zarontin discount of up to 80% off the retail price at participating pharmacies.

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What is Ethosuximide ?

Zarontin is used treat epilepsy. Ethosuximide is the generic version of Zarontin. The average cost of Zarontin is approximately $394 for a supply of 100, 250 mg oral capsules. You can use our Singlecare savings offer to get an average Zarontin discount of up to 80% off the retail price at participating pharmacies.
  • Depression, unusual changes in mood or behavior, thoughts of hurting yourself
  • Fever, chills, cough, sore throat, body aches
  • Blistering, peeling, red skin rash
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Unusual bleeding, bruising, or weakness
  • Swollen glands in your armpits, neck, or groin, chest pain, trouble breathing
  • Yellow skin or eyes
  • Problems with balance or walking, blurred vision, headache
  • Unusual bleeding, bruising, or weakness
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. Your seizures may return or occur more often if you stop this medicine suddenly.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may cause the following problems:LupusUnusual thoughts or behavior (including depression, thoughts of suicide)Serious skin reactions, including Stevens-Johnson syndromeDrug reaction with eosinophilia and systemic symptoms (DRESS), which can be life-threatening
  • Tell your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, blood or bone marrow problems, lupus, or a history of depression or mental health problems.
  • Yellow skin or eyes
  • Unusual bleeding, bruising, or weakness
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is ethosuximide used for?
Ethosuximide is FDA-approved to control absence (petit mal) seizures and is a first-line treatment for childhood absence epilepsy. It is effective only for absence seizures and does not control tonic-clonic or other seizure types; when other seizure types are present, it is combined with additional anticonvulsants.
Is ethosuximide the same as Zarontin?
Yes. Ethosuximide is the generic name, and Zarontin is a brand name for the same medicine. An FDA-approved generic ethosuximide is available and usually costs less than the brand, while containing the same active ingredient.
What are the most common side effects of ethosuximide?
Ethosuximide can cause drowsiness and dizziness. More serious but less common effects include blood problems (such as low blood counts), serious skin and hypersensitivity reactions like Stevens-Johnson syndrome and DRESS, a lupus-like syndrome, and, as with all antiepileptics, a risk of suicidal thoughts or behavior. Contact your provider about any rash, fever, unusual bruising or bleeding, or mood changes.
How long does it take for ethosuximide to work?
Ethosuximide is usually started at a lower dose and adjusted over time to control seizures, so the full benefit may take days to weeks as the dose is titrated. Take it exactly as prescribed and talk with your provider about what to expect for your situation.
Can you stop taking ethosuximide suddenly?
No. Do not stop ethosuximide abruptly. Stopping suddenly can precipitate absence status, a prolonged seizure state. Any dose change or discontinuation should be done gradually and under the guidance of your provider.
How much does Ethosuximide cost without insurance?
The price of Ethosuximide without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Ethosuximide?
Common side effects of Ethosuximide may include: Depression, unusual changes in mood or behavior, thoughts of hurting yourself, Fever, chills, cough, sore throat, body aches, Blistering, peeling, red skin rash, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Unusual bleeding, bruising, or weakness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Ethosuximide?
Generic versions may be available for Ethosuximide. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Ethosuximide on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Ethosuximide?
The cheapest pharmacy for Ethosuximide depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Ethosuximide near you.

Ethosuximide Coupons & Prices

Ethosuximide 250MG

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Ethosuximide Capsule — prescription drug image
Prescription
Ethosuximide 250mg (180)
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Looking for an ethosuximide coupon? Ethosuximide is the low-cost generic form of Zarontin, a succinimide anticonvulsant used to control absence (petit mal) seizures. Because it is already available as an FDA-approved generic, cash prices are generally modest, but they can still vary widely from one pharmacy to the next. Enter your ZIP above to see today's price and compare an ethosuximide discount across more than 60,000 pharmacies with a free Rx.com coupon.

What is ethosuximide and how does it work?

Ethosuximide is a succinimide anticonvulsant (antiepileptic) medicine. It is FDA-approved to control absence seizures, also known as petit mal seizures, and is considered a first-line treatment for childhood absence epilepsy. It comes as capsules and as an oral solution (syrup).

Ethosuximide works only for absence seizures. It does not control tonic-clonic (grand mal) or other seizure types. When a person has more than one type of seizure, ethosuximide is combined with additional anticonvulsant medicines to cover the other seizure types. Always take it exactly as your provider directs.

Ethosuximide cost and savings without insurance

Ethosuximide is available as a generic, which usually keeps the cash price lower than brand-name Zarontin. Even so, what you pay at the counter can differ a lot depending on which pharmacy you use, so comparing prices genuinely matters. Rx.com checks prices across more than 60,000 pharmacies so you can find the lowest ethosuximide price near you. Enter your ZIP above to see today's price and print or text yourself a free coupon.

If you prefer the brand, the manufacturer of Zarontin, Pfizer, offers information about its own savings and patient-assistance programs on its official website; eligibility and terms vary, and those programs are separate from the Rx.com discount. Our coupon requires no insurance and can be used whether you fill the generic or the brand.

Ethosuximide alternatives and related seizure medicines

Ethosuximide is a first-line choice specifically for absence seizures. Depending on a person's seizure types and history, a provider may prescribe or add other anticonvulsants. Related medicines people compare include:

These medicines are not interchangeable with ethosuximide and are chosen based on the seizure type being treated. Only your provider can decide which medicine, or combination, is right for you. You can compare cash prices on any of these with an Rx.com coupon.

Ethosuximide safety and side effects

Ethosuximide can rarely cause serious blood problems (blood dyscrasias) such as agranulocytosis, aplastic anemia, pancytopenia, and leukopenia or eosinophilia, so providers often order periodic blood counts (CBC). Serious skin and hypersensitivity reactions have been reported, including Stevens-Johnson syndrome and DRESS (drug reaction with eosinophilia and systemic symptoms), and a lupus-like (systemic lupus erythematosus-like) syndrome can occur. Like all antiepileptic medicines, ethosuximide carries a class risk of suicidal thoughts or behavior. There have also been reports of effects on liver and kidney function, so those may be monitored.

Ethosuximide may cause drowsiness or dizziness that can impair driving. Do not stop taking it suddenly, because abruptly stopping can trigger absence status (a prolonged seizure state); any change should be guided by your provider. This information is not medical advice. Tell your provider about all your medicines and report any rash, fever, unusual bruising or bleeding, or mood changes right away.

Sources & accuracy

This Ethosuximide information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Ethosuximide on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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