Divalproex Sodium
Divalproex Sodium 500MG
What is Divalproex Sodium?
If you are diagnosed with a seizure disorder, your doctor might prescribe divalproex. Bipolar disorder is also treated in some cases with divalproex. For the prevention of migraine headaches, divalproex might be effective. This medication might be harmful to the fetus, so consult with a doctor if you are considering taking divalproex during pregnancy.Side Effects
- Sudden and severe stomach pain, nausea, vomiting, lightheadedness
- Fever, rash, swollen glands in the neck, armpit, or groin
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, blood disease, pancreas problems, a viral infection (including HIV or cytomegalovirus infection), or a history of depression or mental health problems.
- This medicine may cause the following problems:Liver problemsPancreatitis (swelling of the pancreas)Hyperammonemic encephalopathy (too much ammonia in your blood)Depression or thoughts of suicideBleeding problems (including thrombocytopenia)Hypothermia (low body temperature)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage the organs, including the liver, kidney, or heart
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
Prescription savings · · · ·
What is Divalproex Sodium ?
If you are diagnosed with a seizure disorder, your doctor might prescribe divalproex. Bipolar disorder is also treated in some cases with divalproex. For the prevention of migraine headaches, divalproex might be effective. This medication might be harmful to the fetus, so consult with a doctor if you are considering taking divalproex during pregnancy.- Sudden and severe stomach pain, nausea, vomiting, lightheadedness
- Fever, rash, swollen glands in the neck, armpit, or groin
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Confusion, problems with memory, unusual drowsiness, clumsiness
- Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
- Unusual bleeding, bruising, or weakness
- Thoughts of hurting yourself, depression, unusual changes in behavior or moods
- Tiny red dots on the skin, especially on the lower legs
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, blood disease, pancreas problems, a viral infection (including HIV or cytomegalovirus infection), or a history of depression or mental health problems.
- This medicine may cause the following problems:Liver problemsPancreatitis (swelling of the pancreas)Hyperammonemic encephalopathy (too much ammonia in your blood)Depression or thoughts of suicideBleeding problems (including thrombocytopenia)Hypothermia (low body temperature)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage the organs, including the liver, kidney, or heart
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Divalproex Sodium Coupons & Prices
Divalproex Sodium 500MG
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Looking for a divalproex sodium coupon? Divalproex sodium is the low-cost generic version of Depakote, an anticonvulsant used for certain seizures, manic or mixed episodes of bipolar disorder, and the prevention of migraine headaches. Because it is available as a generic, the cash price is already well below the brand, but what you pay can vary widely from one pharmacy to the next. Enter your ZIP above to see today's price and compare across more than 60,000 U.S. pharmacies before you fill your prescription.
What is divalproex sodium and how does it work?
Divalproex sodium is an antiepileptic (anticonvulsant) medicine in the valproate family. It is FDA-approved to treat certain seizure disorders, including complex partial seizures and simple and complex absence seizures; to treat acute manic or mixed episodes linked to bipolar disorder; and to help prevent migraine headaches. It is sometimes used off-label for other mood or behavioral conditions, but only your prescriber can decide whether it is right for you.
Divalproex is a stable combination of valproic acid and sodium valproate. In the body it releases the active valproate ion, which is thought to work by calming overactive electrical signaling in the brain. It comes in several forms, including Depakote, Depakote ER (extended-release), and Depakote Sprinkle capsules, so the exact product and dose your doctor chooses depends on the condition being treated.
Divalproex sodium cost and savings without insurance
Divalproex sodium is a generic, so it is generally much cheaper than brand-name Depakote. Even so, the cash price is not the same everywhere; two pharmacies in the same town can charge noticeably different amounts for the identical tablets. That is why comparing before you fill matters. Rx.com checks prices across more than 60,000 pharmacies so you can see where it costs the least near you. Enter your ZIP above to see today's price and pick up a free discount coupon you can use even if you do not have insurance, or if your plan does not cover this medication.
If you are prescribed brand-name Depakote or Depakote ER instead of the generic, the manufacturer, AbbVie, offers an official savings program on its Depakote website. Eligibility and terms vary and typically exclude government insurance such as Medicare or Medicaid, so check the details there. In many cases the generic divalproex sodium coupon price shown above will already be the lower option.
Related drugs and alternatives
Divalproex sodium is the generic form of the brand products Depakote and Depakote ER, and it is closely related to valproic acid, another valproate medicine. Depending on the condition, your prescriber may consider other options, and you can compare prices on each:
- Lamotrigine — used for seizures and bipolar disorder
- Topiramate — used for seizures and migraine prevention
- Lithium — used for bipolar disorder
These are not interchangeable and each has its own benefits and risks. Do not switch or stop any medicine without talking to your doctor or pharmacist first.
Important safety information
Divalproex sodium carries serious boxed (black-box) warnings, and this information is not a substitute for advice from your healthcare provider. The three most important risks are: liver damage, which can be severe and even fatal, especially in children under 2 and during the first 6 months of treatment; harm to an unborn baby, including major birth defects such as neural tube defects and lower IQ or neurodevelopmental problems; and pancreatitis, a life-threatening inflammation of the pancreas that can happen at any time. Because of the risk to a developing baby, it should not be used for migraine prevention during pregnancy, and it is generally avoided in women who could become pregnant unless there is no suitable alternative.
Other possible risks include suicidal thoughts or behavior, high blood ammonia levels that can affect the brain, and low platelet counts. It should not be used by people with liver disease, urea cycle disorders, or certain mitochondrial disorders (such as POLG mutations / Alpers-Huttenlocher syndrome). Your doctor will usually order periodic blood tests to check your liver, platelets, and drug levels. Tell your provider about all your medical conditions and medications, and get medical help right away if you notice vomiting, loss of appetite, yellowing of the skin or eyes, severe stomach pain, unusual bruising, or a change in mood.
This Divalproex Sodium information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Divalproex Sodium on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.