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Fenofibrate

Fenofibrate 145MG

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What is Fenofibrate?

Fenofibrate is a medication used to lower cholesterol and triglycerides in the blood. It helps reduce the risk of heart attacks and strokes by speeding up the removal of these fatty substances from the body.

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What is Fenofibrate ?

Fenofibrate is a medication used to lower cholesterol and triglycerides in the blood. It helps reduce the risk of heart attacks and strokes by speeding up the removal of these fatty substances from the body.

Source: MedlinePlus, U.S. National Library of Medicine

  • Muscle pain, tenderness, or weakness
  • Change in how much or how often you urinate
  • Unusual bleeding, bruising, or weakness
  • Chest pain, trouble breathing, coughing up blood
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Sudden and severe stomach pain, nausea, vomiting, fever, loss of appetite
  • Dark urine or pale stools, yellow skin or eyes
  • Blistering, peeling, red skin rash
  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, heart disease, blood clotting problems, diabetes, or thyroid problems.
  • Do not breastfeed during treatment and for at least 5 days after the last dose.
  • This medicine may cause the following problems: Liver problemsSerious muscle problems (including myopathy), especially when used with other medicinesRhabdomyolysis (severe muscle weakness) that could lead to kidney damagePancreatitisIncreased risk of gallstonesSerious skin reactions, including Steven-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Unusual bleeding, bruising, or weakness
What is fenofibrate used for?
Fenofibrate is FDA-approved, along with a healthy diet, to lower high LDL cholesterol, total cholesterol, triglycerides, and apolipoprotein B and to raise HDL cholesterol in adults with primary high cholesterol or mixed dyslipidemia. It is also approved to treat severe hypertriglyceridemia (very high triglycerides) in people at risk of pancreatitis.
Is fenofibrate a statin?
No. Fenofibrate is a fibrate (a fibric acid derivative), not a statin. Statins mainly lower LDL cholesterol, while fenofibrate mainly lowers triglycerides and can modestly raise HDL. They work in different ways.
Can you take fenofibrate and a statin together?
Yes, a provider sometimes prescribes fenofibrate together with a statin for mixed cholesterol problems, but this combination raises the risk of muscle problems and should be monitored. Large trials such as ACCORD found that adding a fibrate to a statin did not further reduce cardiovascular events. Only combine them under your provider's guidance.
What are the most common side effects of fenofibrate?
Reported effects include muscle aches or, rarely, serious muscle breakdown (especially with a statin or in kidney impairment), gallstones, elevated liver enzymes, reversible increases in serum creatinine, and pancreatitis. Contact your provider if you notice unexplained muscle pain, weakness, or belly pain. Discuss any side effects with your provider or pharmacist.
Should fenofibrate be taken with food?
It depends on the specific product, because different fenofibrate formulations have different food instructions. Follow the directions on your prescription label and ask your pharmacist whether your particular version should be taken with food.
How much does Fenofibrate cost without insurance?
The price of Fenofibrate without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Fenofibrate?
Common side effects of Fenofibrate may include: Muscle pain, tenderness, or weakness, Change in how much or how often you urinate, Unusual bleeding, bruising, or weakness, Chest pain, trouble breathing, coughing up blood, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Fenofibrate?
Generic versions may be available for Fenofibrate. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Fenofibrate on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Fenofibrate?
The cheapest pharmacy for Fenofibrate depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Fenofibrate near you.

Fenofibrate Coupons & Prices

Fenofibrate 145MG

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Fenofibrate Tablet — prescription drug image
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Looking for a fenofibrate coupon? Fenofibrate is a widely used generic fibrate that lowers high triglycerides and cholesterol, and because it is available as a low-cost generic, you do not need to pay full retail. The catch is that the cash price for the exact same prescription can vary a lot from one pharmacy to the next, so comparing matters. Rx.com checks fenofibrate prices across more than 60,000 pharmacies so you can find a genuinely low price near you. Enter your ZIP above to see today's price and print or text yourself a free discount coupon.

What is fenofibrate and how does it work?

Fenofibrate is a lipid-lowering medicine in the fibrate class (a fibric acid derivative that works as a PPAR-alpha agonist). It is FDA-approved, as an add-on to diet, to reduce elevated LDL ("bad") cholesterol, total cholesterol, triglycerides, and apolipoprotein B, and to raise HDL ("good") cholesterol in adults with primary high cholesterol or mixed dyslipidemia. It is also approved to treat severe hypertriglyceridemia (very high triglycerides) in patients who are at risk of pancreatitis. It is sold under several brand names including Tricor, Antara, Lipofen, Fenoglide, Triglide, and Lofibra, while the closely related fenofibric acid is marketed as Trilipix and Fibricor.

Fenofibrate mainly lowers triglycerides and can modestly raise HDL, which makes it different from statins that primarily lower LDL. Your provider decides which medicine, or combination, fits your cholesterol profile.

Fenofibrate cost and coupon savings

Fenofibrate is available as a generic, and generics are already far cheaper than brand-name versions. Even so, the cash price you would pay without insurance can differ widely between pharmacies in the same town, which is exactly why comparing before you fill is worth the few seconds it takes. A free Rx.com discount coupon is accepted at most major pharmacies and often beats the pharmacy's standard cash price, and in some cases it can even come in under an insurance copay.

Because prices change and depend on your pharmacy, strength, and quantity, we show them live rather than quoting a figure here. Enter your ZIP above to see today's fenofibrate price near you and grab your coupon. Rx.com compares more than 60,000 pharmacies so you can pick the lowest one.

Alternatives and related medicines

Fenofibrate is not the only option for high cholesterol or triglycerides, and your provider may consider a different medicine or a combination. Related and alternative drugs include:

Each of these is priced differently at each pharmacy, so it can pay to compare whichever one you are prescribed. This is general information, not a recommendation — talk with your provider about which treatment is right for you.

Safety and side effects to know

Fenofibrate has no boxed warning, but there are important cautions. It can cause muscle problems (myopathy and, rarely, serious muscle breakdown called rhabdomyolysis), especially when combined with a statin or used in people with kidney impairment. It may lead to gallstones that sometimes require gallbladder surgery, and it can raise liver enzymes, so your provider may check liver function. Fenofibrate can also cause reversible increases in serum creatinine, and it is used with caution or dose-adjusted in kidney impairment and avoided in severe kidney disease or on dialysis. Pancreatitis has been reported.

It can strengthen the effect of blood thinners such as warfarin, so INR may need monitoring. Fenofibrate is contraindicated in severe kidney disease, active liver disease, preexisting gallbladder disease, nursing mothers, and anyone with a known allergy to it. Note that in large trials such as ACCORD, adding a fibrate to a statin did not reduce cardiovascular event risk. This is not medical advice — take fenofibrate exactly as prescribed and discuss any concerns or side effects with your provider or pharmacist.

Sources & accuracy

This Fenofibrate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Fenofibrate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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