Hydrocortisone (Perianal)
Hydrocortisone (Perianal) 30GM of 2.5%
What is Hydrocortisone (Perianal)?
Proctocort is an anti-inflammatory used to treat inflammation of the rectum and anus. Hydrocortisone Topical is the generic version. The average Proctocort price is a bit expensive, at about $54 for a supply of 1 tube, 28.4gm of 1%. You can use our Rx.com savings offer to get an average Proctocort discount of up to 80% off of the retail price at participating pharmacies near you.Side Effects
- Dark freckles, skin color changes, coldness, weakness, tiredness, nausea, vomiting, weight loss
- Eye pain, vision changes
- Dry mouth, increased thirst, muscle cramps, nausea or vomiting, uneven heartbeat
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have heart problems, high blood pressure, diabetes, kidney disease, cirrhosis, osteoporosis, thyroid problems, or myasthenia gravis. Tell your doctor if you have digestive problems, including ulcer, colitis, or diverticulitis.
- This medicine may cause the following problems:Cataracts or glaucomaHigh blood pressureIncreased risk for osteoporosisAdrenal gland problems
- This medicine may cause you to get infections more easily. Tell your doctor if you have any type of infection before you start treatment. Avoid people who are sick or have infections. If you are exposed to chickenpox or measles, tell your doctor right away.
- This medicine may delay growth in children. If you think your child is not growing properly while using this medicine, talk with your doctor.
- Call your doctor if your symptoms do not improve or if they get worse.
Prescription savings · · · ·
What is Hydrocortisone (Perianal) ?
Proctocort is an anti-inflammatory used to treat inflammation of the rectum and anus. Hydrocortisone Topical is the generic version. The average Proctocort price is a bit expensive, at about $54 for a supply of 1 tube, 28.4gm of 1%. You can use our Rx.com savings offer to get an average Proctocort discount of up to 80% off of the retail price at participating pharmacies near you.- Dark freckles, skin color changes, coldness, weakness, tiredness, nausea, vomiting, weight loss
- Eye pain, vision changes
- Dry mouth, increased thirst, muscle cramps, nausea or vomiting, uneven heartbeat
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Rapid weight gain, swelling in your hands, ankles, or feet
- Depression, mood swings, trouble sleeping, usual thoughts, feelings, or behavior
- Fever, chills, cough, sore throat, body aches
- Tell your doctor if you are pregnant or breastfeeding, or if you have heart problems, high blood pressure, diabetes, kidney disease, cirrhosis, osteoporosis, thyroid problems, or myasthenia gravis. Tell your doctor if you have digestive problems, including ulcer, colitis, or diverticulitis.
- This medicine may cause the following problems:Cataracts or glaucomaHigh blood pressureIncreased risk for osteoporosisAdrenal gland problems
- This medicine may cause you to get infections more easily. Tell your doctor if you have any type of infection before you start treatment. Avoid people who are sick or have infections. If you are exposed to chickenpox or measles, tell your doctor right away.
- This medicine may delay growth in children. If you think your child is not growing properly while using this medicine, talk with your doctor.
- Call your doctor if your symptoms do not improve or if they get worse.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Hydrocortisone (Perianal) Coupons & Prices
Hydrocortisone (Perianal) 30GM of 2.5%
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a hydrocortisone-perianal coupon? Prescription-strength 2.5% hydrocortisone rectal/perianal cream is a low-cost generic corticosteroid used for the temporary relief of itching, swelling, discomfort, and inflammation from hemorrhoids and other anorectal conditions. Because the cash price for this generic can vary widely from one pharmacy to the next, comparing matters. Enter your ZIP above to see today's price at pharmacies near you, with Rx.com comparing prices across more than 60,000 pharmacies.
What is hydrocortisone perianal cream and how does it work?
Hydrocortisone (rectal/perianal) is a corticosteroid, a type of glucocorticoid that works by calming inflammation. The prescription 2.5% cream is used for the temporary relief of itching, swelling, discomfort, and inflammation caused by hemorrhoids and other inflammatory anorectal conditions, such as proctitis, anal fissures, and pruritus ani (anal itching). It is sold under brand names including Anusol-HC, Proctocream-HC, Proctosol-HC, and Anucort-HC.
Other rectal forms of hydrocortisone, such as suppositories, enemas, and foam (for example Cortifoam), are also used as an add-on treatment for ulcerative colitis and proctitis. A generic version is available. Note that some rectal cream products are marketed without full FDA approval of their labeling.
How much does hydrocortisone perianal cream cost without insurance?
Hydrocortisone perianal cream is available as a generic, which typically keeps the cash price lower than a brand-name equivalent. Even so, what you actually pay can differ a lot depending on which pharmacy you use, so it pays to compare before you fill. Rx.com compares prices across more than 60,000 pharmacies so you can find a lower cash price near you, even without insurance.
Prices change often and are shown live on this page. Enter your ZIP above to see today's price, then bring your free coupon to the pharmacy counter. If you also want the brand-name option, you can compare Anusol-HC pricing the same way.
Related and alternative products
Hydrocortisone perianal cream is one of several options for anorectal itching and inflammation. Depending on what your provider recommends, you may want to compare related products:
- Hydrocortisone — the base corticosteroid in other strengths and forms.
- Anusol-HC — a brand-name hydrocortisone anorectal product.
- Proctofoam-HC — a rectal foam combining hydrocortisone with pramoxine.
- Lidocaine-hydrocortisone — pairs a numbing agent with the steroid.
- Pramoxine-hydrocortisone — pairs a topical anesthetic with the steroid.
Your provider or pharmacist can help you decide which product fits your situation. Use the tool above to compare live prices on any of these.
Safety and important information
Hydrocortisone perianal cream has no boxed warning, but it should be used only as directed for external/perianal use. Do not insert the applicator more than 1/2 to 1 inch into the anus. Prolonged use of topical corticosteroids can cause skin thinning, stretch marks (striae), and local irritation or burning. The medicine can be absorbed into the body, especially with occlusion, use over large areas, or prolonged use, which can lead to reversible effects on hormone regulation (HPA-axis suppression), higher blood sugar, and, rarely, Cushing's syndrome. It should not be used on infected areas without treating the infection at the same time.
Stop and contact your doctor if your symptoms do not improve within 7 days, get worse, or if bleeding occurs. Use with caution during pregnancy and in children, who absorb relatively more of the medicine. This information is not medical advice; talk with your doctor or pharmacist about whether this medicine is right for you.
This Hydrocortisone (Perianal) information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Hydrocortisone (Perianal) on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.