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Hysingla Er Tablet Er 24 Hour Abuse-Deterrent — prescription drug image

Hysingla Er

Hysingla ER 20MG

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What is Hysingla Er?

Hysingla ER is an extended-release (long-lasting) tablet that is used to treat chronic and severe pain. Hydrocodone is the generic version of Hysingla ER. For 30 tablets of Hysingla ER 20 mg, the average cost is $425. You can use Rx.com’s free coupon card for easy and fast savings on your Hysingla ER price.

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What is Hysingla Er ?

Hysingla ER is an extended-release (long-lasting) tablet that is used to treat chronic and severe pain. Hydrocodone is the generic version of Hysingla ER. For 30 tablets of Hysingla ER 20 mg, the average cost is $425. You can use Rx.com’s free coupon card for easy and fast savings on your Hysingla ER price.
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Severe confusion, lightheadedness, dizziness, or fainting
  • Blue lips, fingernails, or skin, trouble breathing
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
  • Extreme dizziness, drowsiness, or weakness, slow heartbeat, seizures, and cold, clammy skin
  • Worsening of pain, increased sensitivity to pain
  • Fast, pounding, or uneven heartbeat
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, breathing or lung problems (including apnea), heart failure, heart rhythm problems (including congenital long QT syndrome, slow heartbeat), adrenal problems, digestion problems, pancreas problems, or a history of depression, head injury, seizures, or drug or alcohol abuse.
  • This medicine may cause the following problems:High risk of overdose, which can lead to deathWorsening of painRespiratory depression (serious breathing problem that can be life-threatening)Adrenal gland problemsLow blood pressureIncreased risk of heart rhythm problem, including QT prolongationIncreased risk of seizuresSerotonin syndrome, when used with certain medicines
  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation. Drink plenty of liquids to help avoid constipation.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
Is Hysingla ER the same as regular hydrocodone?
It contains the same active drug, hydrocodone, but it is not the same product. Hysingla ER is a single-ingredient, extended-release tablet designed to release the medication slowly over 24 hours for once-daily, around-the-clock pain control. Regular (immediate-release) hydrocodone is usually combined with acetaminophen and is taken several times a day for shorter-term pain.
Is Hysingla ER a strong painkiller?
Yes. Hysingla ER is a strong opioid (narcotic) analgesic and a Schedule II controlled substance. It is only approved for pain severe enough to require daily, around-the-clock, long-term opioid treatment when other options are inadequate. It is not intended for mild or short-term pain.
How long does one Hysingla ER tablet last?
Hysingla ER is an extended-release tablet taken once a day, so a single tablet is designed to provide pain control over about 24 hours. It is not an as-needed painkiller. Take it exactly as your prescriber directs.
Is there a generic version of Hysingla ER?
Yes, a generic version of extended-release hydrocodone is available. The generic usually costs less than the brand, so ask your pharmacist about it and use the price tool above to compare the brand and generic cash prices at pharmacies near you.
Can you crush or chew Hysingla ER tablets?
No. Hysingla ER tablets must be swallowed whole. Crushing, chewing, breaking, or dissolving a tablet can release the full dose at once, which can cause a fatal overdose. The tablet is designed with abuse-deterrent properties to resist this, but it should still only ever be swallowed whole with enough water.
How much does Hysingla Er cost without insurance?
The price of Hysingla Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Hysingla Er?
Common side effects of Hysingla Er may include: Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there, Severe confusion, lightheadedness, dizziness, or fainting, Blue lips, fingernails, or skin, trouble breathing, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Changes in skin color, dark freckles, cold feeling, tiredness, weight loss. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Hysingla Er?
Generic versions may be available for Hysingla Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Hysingla Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Hysingla Er?
The cheapest pharmacy for Hysingla Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Hysingla Er near you.

Hysingla Er Coupons & Prices

Hysingla ER 20MG

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Hysingla Er Tablet Er 24 Hour Abuse-Deterrent — prescription drug image
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Hysingla Er 20mg (30)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a Hysingla ER coupon? Rx.com offers a free cash discount coupon you can use at the pharmacy counter for Hysingla ER (extended-release hydrocodone), the once-daily, around-the-clock opioid tablet used for severe long-term pain. Whether you are paying cash, on Medicare, or your insurance does not cover this medication, enter your ZIP above to see today's discounted price at pharmacies near you. Because a generic version of Hysingla ER is available, we will also show you the generic price, which is often the biggest way to lower your cost.

What is Hysingla ER and how does it work?

Hysingla ER is a brand-name, single-ingredient extended-release tablet of hydrocodone bitartrate, a strong opioid (narcotic) pain reliever. It is FDA-approved for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment when other options, including immediate-release opioids, are not enough. It is taken once daily and is designed to release medication slowly over 24 hours. It also has abuse-deterrent properties that make the tablet hard to crush or dissolve.

Hysingla ER is not meant for mild pain, short-term pain, or pain you only feel now and then. It is not an as-needed (prn) painkiller. Because it is a Schedule II controlled substance, it is only available through the Opioid Analgesic REMS program. This information is educational and not a substitute for your prescriber's guidance.

Hysingla ER cost: manufacturer savings card vs. Rx.com cash coupon

Two main ways to lower your out-of-pocket cost look very different. Purdue Pharma, the maker of Hysingla ER, runs an official patient savings program listed on its own website (purduepharma.com). Manufacturer copay cards like this are generally limited to people with commercial (private) insurance, and the terms, eligibility, and any limits vary and change over time. They typically cannot be used if you have Medicare, Medicaid, or other government coverage, or if you are uninsured.

The Rx.com cash coupon works differently. It is a cash-price discount, so it does not require insurance at all. That makes it useful if you are uninsured, on Medicare, or if the manufacturer card is declined at the pharmacy. You cannot combine a cash coupon with insurance on the same purchase, but you can compare which price is lower. The single biggest savings lever here is the generic: because generic extended-release hydrocodone is available, ask your pharmacist about the generic price. Enter your ZIP above to see both the brand and generic prices at pharmacies near you today.

Alternatives and related medications

Hysingla ER is one of several long-acting opioid options. Another single-ingredient extended-release hydrocodone product is Zohydro ER. Extended-release oxycodone is sold as OxyContin, and long-acting morphine as morphine sulfate ER. For pain that does not need an around-the-clock long-acting opioid, shorter-acting or lower-potency options such as hydrocodone-acetaminophen or tramadol may be used.

These medications differ in strength, duration, and how they are dosed, and switching between opioids must be done carefully by a prescriber. Do not switch on your own. Use the price tool above to compare cash prices on any of these that your provider has prescribed.

Important safety information

Hysingla ER carries FDA boxed warnings. It has a risk of addiction, abuse, and misuse that can lead to overdose and death, so your prescriber should assess your risk and monitor you regularly. It can cause life-threatening slowed or stopped breathing, especially when you start it or increase the dose; the full effect of a dose change may not appear for 24 to 72 hours. A single dose can be fatal if taken by a child or anyone it was not prescribed for, so store it securely. Used during pregnancy, it can cause withdrawal in a newborn.

Do not drink alcohol while taking Hysingla ER, because alcohol can cause a dangerous rapid release of the full dose. Combining it with benzodiazepines, other CNS depressants, or certain medications that affect the CYP3A4 enzyme can cause profound sedation, slowed breathing, coma, or death. Other risks include adrenal problems, very low blood pressure, and heart-rhythm changes (QTc prolongation) at high doses. This is not a complete list. Talk with your doctor or pharmacist about your full medication list and any questions before starting or changing treatment.

Sources & accuracy

This Hysingla Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Hysingla Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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