Hysingla Er
Hysingla ER 20MG
What is Hysingla Er?
Hysingla ER is an extended-release (long-lasting) tablet that is used to treat chronic and severe pain. Hydrocodone is the generic version of Hysingla ER. For 30 tablets of Hysingla ER 20 mg, the average cost is $425. You can use Rx.com’s free coupon card for easy and fast savings on your Hysingla ER price.Side Effects
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Severe confusion, lightheadedness, dizziness, or fainting
- Blue lips, fingernails, or skin, trouble breathing
Warnings
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, breathing or lung problems (including apnea), heart failure, heart rhythm problems (including congenital long QT syndrome, slow heartbeat), adrenal problems, digestion problems, pancreas problems, or a history of depression, head injury, seizures, or drug or alcohol abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathWorsening of painRespiratory depression (serious breathing problem that can be life-threatening)Adrenal gland problemsLow blood pressureIncreased risk of heart rhythm problem, including QT prolongationIncreased risk of seizuresSerotonin syndrome, when used with certain medicines
- This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
Prescription savings · · · ·
What is Hysingla Er ?
Hysingla ER is an extended-release (long-lasting) tablet that is used to treat chronic and severe pain. Hydrocodone is the generic version of Hysingla ER. For 30 tablets of Hysingla ER 20 mg, the average cost is $425. You can use Rx.com’s free coupon card for easy and fast savings on your Hysingla ER price.- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Severe confusion, lightheadedness, dizziness, or fainting
- Blue lips, fingernails, or skin, trouble breathing
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
- Extreme dizziness, drowsiness, or weakness, slow heartbeat, seizures, and cold, clammy skin
- Worsening of pain, increased sensitivity to pain
- Fast, pounding, or uneven heartbeat
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, breathing or lung problems (including apnea), heart failure, heart rhythm problems (including congenital long QT syndrome, slow heartbeat), adrenal problems, digestion problems, pancreas problems, or a history of depression, head injury, seizures, or drug or alcohol abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathWorsening of painRespiratory depression (serious breathing problem that can be life-threatening)Adrenal gland problemsLow blood pressureIncreased risk of heart rhythm problem, including QT prolongationIncreased risk of seizuresSerotonin syndrome, when used with certain medicines
- This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation. Drink plenty of liquids to help avoid constipation.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Hysingla Er Coupons & Prices
Hysingla ER 20MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a Hysingla ER coupon? Rx.com offers a free cash discount coupon you can use at the pharmacy counter for Hysingla ER (extended-release hydrocodone), the once-daily, around-the-clock opioid tablet used for severe long-term pain. Whether you are paying cash, on Medicare, or your insurance does not cover this medication, enter your ZIP above to see today's discounted price at pharmacies near you. Because a generic version of Hysingla ER is available, we will also show you the generic price, which is often the biggest way to lower your cost.
What is Hysingla ER and how does it work?
Hysingla ER is a brand-name, single-ingredient extended-release tablet of hydrocodone bitartrate, a strong opioid (narcotic) pain reliever. It is FDA-approved for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment when other options, including immediate-release opioids, are not enough. It is taken once daily and is designed to release medication slowly over 24 hours. It also has abuse-deterrent properties that make the tablet hard to crush or dissolve.
Hysingla ER is not meant for mild pain, short-term pain, or pain you only feel now and then. It is not an as-needed (prn) painkiller. Because it is a Schedule II controlled substance, it is only available through the Opioid Analgesic REMS program. This information is educational and not a substitute for your prescriber's guidance.
Hysingla ER cost: manufacturer savings card vs. Rx.com cash coupon
Two main ways to lower your out-of-pocket cost look very different. Purdue Pharma, the maker of Hysingla ER, runs an official patient savings program listed on its own website (purduepharma.com). Manufacturer copay cards like this are generally limited to people with commercial (private) insurance, and the terms, eligibility, and any limits vary and change over time. They typically cannot be used if you have Medicare, Medicaid, or other government coverage, or if you are uninsured.
The Rx.com cash coupon works differently. It is a cash-price discount, so it does not require insurance at all. That makes it useful if you are uninsured, on Medicare, or if the manufacturer card is declined at the pharmacy. You cannot combine a cash coupon with insurance on the same purchase, but you can compare which price is lower. The single biggest savings lever here is the generic: because generic extended-release hydrocodone is available, ask your pharmacist about the generic price. Enter your ZIP above to see both the brand and generic prices at pharmacies near you today.
Alternatives and related medications
Hysingla ER is one of several long-acting opioid options. Another single-ingredient extended-release hydrocodone product is Zohydro ER. Extended-release oxycodone is sold as OxyContin, and long-acting morphine as morphine sulfate ER. For pain that does not need an around-the-clock long-acting opioid, shorter-acting or lower-potency options such as hydrocodone-acetaminophen or tramadol may be used.
These medications differ in strength, duration, and how they are dosed, and switching between opioids must be done carefully by a prescriber. Do not switch on your own. Use the price tool above to compare cash prices on any of these that your provider has prescribed.
Important safety information
Hysingla ER carries FDA boxed warnings. It has a risk of addiction, abuse, and misuse that can lead to overdose and death, so your prescriber should assess your risk and monitor you regularly. It can cause life-threatening slowed or stopped breathing, especially when you start it or increase the dose; the full effect of a dose change may not appear for 24 to 72 hours. A single dose can be fatal if taken by a child or anyone it was not prescribed for, so store it securely. Used during pregnancy, it can cause withdrawal in a newborn.
Do not drink alcohol while taking Hysingla ER, because alcohol can cause a dangerous rapid release of the full dose. Combining it with benzodiazepines, other CNS depressants, or certain medications that affect the CYP3A4 enzyme can cause profound sedation, slowed breathing, coma, or death. Other risks include adrenal problems, very low blood pressure, and heart-rhythm changes (QTc prolongation) at high doses. This is not a complete list. Talk with your doctor or pharmacist about your full medication list and any questions before starting or changing treatment.
This Hysingla Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Hysingla Er on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.