Nextstellis
Nextstellis 3-14.2MG
What is Nextstellis?
Nextstellis is a prescription medication that combines two hormones, drospirenone and estetrol. It is used to prevent pregnancy and may help with menstrual cycle regulation.Side Effects
- Chest pain, trouble breathing, coughing up blood
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dark urine or pale stools, loss of appetite, nausea, vomiting, stomach pain, yellow skin or eyes
Warnings
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases. Talk with your doctor if you have questions.
- You might have some light bleeding or spotting, especially during the first 4 months of using this medicine. This is usually normal and should not last long. However, if you have heavy bleeding or the bleeding lasts more than a few days in a row, call your doctor.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- If you miss a menstrual period, call your doctor for a pregnancy test before you take any more pills.
Prescription savings · · · ·
What is Nextstellis ?
Nextstellis is a prescription medication that combines two hormones, drospirenone and estetrol. It is used to prevent pregnancy and may help with menstrual cycle regulation.- Chest pain, trouble breathing, coughing up blood
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dark urine or pale stools, loss of appetite, nausea, vomiting, stomach pain, yellow skin or eyes
- Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
- Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, problems with vision, speech, or walking
- Unusual or unexpected vaginal bleeding or heavy bleeding
- Blurred vision, slow or fast heartbeat, lightheadedness, dizziness
- Breast lumps, tenderness, pain, swelling, or discharge
- Irregular, late, or missed menstrual period
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases. Talk with your doctor if you have questions.
- You might have some light bleeding or spotting, especially during the first 4 months of using this medicine. This is usually normal and should not last long. However, if you have heavy bleeding or the bleeding lasts more than a few days in a row, call your doctor.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- If you miss a menstrual period, call your doctor for a pregnancy test before you take any more pills.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. Tell your doctor if you are having a surgery that requires inactivity for a long time.
- This medicine may cause skin discoloration. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
- Tell your doctor if you are breastfeeding, or if you have given birth within 4 weeks before you start using this medicine. Tell your doctor if you have gallbladder disease, high blood pressure, high cholesterol, diabetes, hereditary angioedema, or a history of depression, chloasma, jaundice (yellow skin or eyes) during pregnancy, or irregular monthly periods. Tell your doctor if you smoke.
- This medicine may cause the following problems:Increased risk of blood clots, heart attack, or strokeEye or vision problemsHigh blood pressureMigraine headachesIncreased risk of cervical cancerLiver problems (including liver cancer or tumors)High cholesterol in the bloodGallbladder disease
Nextstellis Coupons & Prices
Nextstellis 3-14.2MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a Nextstellis coupon? Nextstellis is a brand-name prescription birth control pill that combines estetrol (E4), a naturally occurring estrogen, with the progestin drospirenone. There is no generic version yet, so the price can be high without help. Rx.com offers a free cash discount coupon you can use at the pharmacy counter whether or not you have insurance. Enter your ZIP code above to see today's Nextstellis price near you.
What is Nextstellis and how does it work?
Nextstellis is an FDA-approved combination oral contraceptive (a daily birth control pill) used to prevent pregnancy in females of reproductive potential. It is the first birth control pill to use estetrol (E4), a naturally occurring estrogen, paired with drospirenone, a progestin related to spironolactone. Together these hormones help prevent pregnancy.
Each pack is a 28-day supply: 24 active pink tablets followed by 4 inactive white tablets, taken one pill a day at the same time each day. Nextstellis does not protect against HIV/AIDS or other sexually transmitted infections, and it is not intended for emergency ("morning after") contraception.
Nextstellis cost: manufacturer savings card vs. Rx.com cash coupon
The company behind Nextstellis offers an official manufacturer savings program on the Nextstellis website. These manufacturer copay cards are generally limited to people with commercial (private) insurance, and the terms, eligibility, and expiration dates change over time, so check the current details directly. Manufacturer cards typically cannot be used if you have Medicare, Medicaid, or other government coverage.
The Rx.com cash coupon is different: it is a discount on the cash price, so it can help if you are uninsured, have Medicare, or if the manufacturer card is declined at the pharmacy. There is no generic version of Nextstellis available yet, so a cash discount is often the most practical savings lever for those who do not qualify for the commercial copay card. Enter your ZIP above to see today's price at pharmacies near you, and ask the manufacturer or your provider whether any patient-assistance option applies to your situation.
Nextstellis alternatives and how it compares
Nextstellis is often compared with other drospirenone-based pills. Yaz and Yasmin also use drospirenone, but they pair it with ethinyl estradiol (a synthetic estrogen) rather than estetrol. Slynd is a progestin-only pill that uses drospirenone without any estrogen, which can be an option for people who need to avoid estrogen. Generic drospirenone-containing pills are available in some of these product families and are usually far cheaper.
The right pill depends on your health history, tolerance for side effects, and whether you can take estrogen. This is background information only, not medical advice; talk with your provider about which contraceptive fits you best.
Safety and side effects to know
Nextstellis carries a boxed warning: cigarette smoking raises the risk of serious cardiovascular events with combination hormonal contraceptives, and this risk grows with age and heavier smoking (15 or more cigarettes a day). Women over 35 who smoke should not use Nextstellis. It is contraindicated in people at high risk for blood clots or artery problems (such as a current or past DVT/PE, stroke, heart attack, uncontrolled high blood pressure, certain migraines with aura, or thrombophilia), and in those with liver tumors, liver disease, breast or other hormone-sensitive cancers, undiagnosed abnormal uterine bleeding, or who take certain hepatitis C drug combinations (ombitasvir/paritaprevir/ritonavir).
Because drospirenone can raise potassium, your provider may monitor levels if you have kidney, liver, or adrenal problems or take other potassium-raising medicines. Other risks include gallbladder disease and raised blood pressure, and enzyme-inducing drugs can reduce effectiveness. Common side effects include irregular bleeding, mood changes, headache, breast symptoms, nausea, acne, weight changes, and menstrual cramps. This is not a complete list and not medical advice; review your full history with your provider or pharmacist.
This Nextstellis information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Nextstellis on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.