Oxycodone-Acetaminophen
oxyCODONE-Acetaminophen 5-325MG
What is Oxycodone-Acetaminophen?
Oxycodone-Acetaminophen (Endocet) is a prescription opioid pain medication used to treat moderate to severe pain when other pain relievers are not sufficient. It combines oxycodone, a powerful opioid analgesic, with acetaminophen to provide enhanced pain relief. Learn about Oxycodone-Acetaminophen uses, dosage, side effects, risks, and important opioid safety information.
Side Effects
- Lightheadedness, dizziness, or fainting
- Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
- Blue lips, fingernails, or skin, change or loss of consciousness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, pinpoint pupils
Warnings
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
Prescription savings · · · ·
What is Oxycodone-Acetaminophen ?
Oxycodone-Acetaminophen (Endocet) is a prescription opioid pain medication used to treat moderate to severe pain when other pain relievers are not sufficient. It combines oxycodone, a powerful opioid analgesic, with acetaminophen to provide enhanced pain relief. Learn about Oxycodone-Acetaminophen uses, dosage, side effects, risks, and important opioid safety information.
- Lightheadedness, dizziness, or fainting
- Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
- Blue lips, fingernails, or skin, change or loss of consciousness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, pinpoint pupils
- Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
- Blistering, peeling, red skin rash
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Confusion, trouble breathing, numbness or tingling in your hands, feet, or lips
- Trouble breathing or slow breathing
- Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Liver problemsSerious skin reactions, including acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and toxic epidermal necrolysisAdrenal gland problemsLow blood pressureSeizuresSerotonin syndrome, when used with certain medicines
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, low blood pressure, breathing problems or lung disease (including COPD, sleep apnea), thyroid problems, Addison disease, pancreas or gallbladder problems, prostate problems, trouble urinating, or a stomach problems, or a history of head injury or brain damage, seizures, or alcohol or drug abuse. Tell your doctor if you are allergic to codeine.
Oxycodone-Acetaminophen Coupons & Prices
oxyCODONE-Acetaminophen 5-325MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for an oxycodone-acetaminophen coupon? Oxycodone/acetaminophen is the generic version of Percocet (and brands like Endocet, Roxicet, Primlev, and Nalocet), a prescription opioid pain reliever used for acute pain severe enough to need an opioid. Because it is a generic, it is already one of the lower-cost options at the pharmacy, but the cash price can still vary widely from one pharmacy to the next. Rx.com compares live prices across 60,000+ pharmacies so you can find today's best price near you. Enter your ZIP above to see today's price and print or text yourself a free discount coupon.
What is oxycodone-acetaminophen and how does it work?
Oxycodone/acetaminophen is a combination pain medicine that pairs two ingredients: oxycodone, an opioid (narcotic) analgesic, and acetaminophen, a non-opioid pain reliever and fever reducer. The oxycodone works in the brain and nervous system to change how your body senses pain, while the acetaminophen adds extra pain relief. It is a Schedule C-II controlled substance, meaning it has accepted medical use but a high potential for misuse and dependence.
The FDA has approved it for the management of acute pain that is severe enough to require an opioid and for which non-opioid treatments are not enough. It is most commonly prescribed for short-term situations such as pain after surgery, an injury, or dental work. It is not intended for mild pain or for routine long-term use. Always take it exactly as your prescriber directs.
Oxycodone-acetaminophen cost and coupons without insurance
Oxycodone/acetaminophen is available as a generic, which is typically far less expensive than the brand-name versions. Even so, the cash price without insurance can differ a lot depending on which pharmacy you use, so comparing prices is worth the effort. Rx.com checks live prices at more than 60,000 pharmacies and gives you a free discount coupon you can use with or without insurance.
To see what you would pay today, enter your ZIP code above. We show the current price at pharmacies near you so you can pick the lowest one. Prices change often, so we always display the live price on this page rather than a fixed number. This is a manufacturer-independent discount, not insurance, and there is no manufacturer savings card for this generic combination.
Related medications and alternatives
Oxycodone/acetaminophen is the generic equivalent of the brand Percocet. Depending on your needs, your prescriber may consider other pain medicines. Related options people often compare include:
- Oxycodone — the opioid ingredient on its own, without acetaminophen.
- Hydrocodone/acetaminophen — another common opioid-plus-acetaminophen combination.
- Tramadol — a different opioid analgesic sometimes used for moderate pain.
- Acetaminophen — the non-opioid ingredient alone, for milder pain.
- OxyContin — an extended-release oxycodone product.
Which option is right for you is a decision for you and your healthcare provider. This is not medical advice.
Important safety information
Oxycodone/acetaminophen carries FDA boxed warnings. It can lead to addiction, abuse, and misuse, which can cause overdose and death. It can cause life-threatening slowed breathing (respiratory depression), especially when first starting or after a dose increase. Accidental ingestion, especially by a child, can be fatal, so store it safely out of reach. Using it during pregnancy can cause opioid withdrawal in the newborn. Combining it with benzodiazepines, other sedatives, or alcohol can cause profound sedation, slowed breathing, coma, and death.
The acetaminophen portion can cause severe liver damage. Do not exceed 4,000 mg of acetaminophen per day from all sources, and watch for acetaminophen in other over-the-counter and prescription products. Other possible risks include serotonin syndrome, adrenal insufficiency, severe low blood pressure, and constipation. It should not be used if you have significant breathing problems, severe asthma, or a blocked or paralyzed gut. Certain drugs that affect the CYP3A4 enzyme can cause dangerous interactions. Take it only as prescribed, and talk with your doctor or pharmacist about your full medication list. This information is not a substitute for professional medical advice.
This Oxycodone-Acetaminophen information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Oxycodone-Acetaminophen on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.