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Sucralfate

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What is Sucralfate?

Sucralfate is a medication used to treat and prevent duodenal ulcers, which are sores in the first part of the small intestine. It helps protect the damaged tissue, allowing it to heal.

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What is Sucralfate ?

Sucralfate is a medication used to treat and prevent duodenal ulcers, which are sores in the first part of the small intestine. It helps protect the damaged tissue, allowing it to heal.

Source: MedlinePlus, U.S. National Library of Medicine

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, coughing up blood
  • Increased hunger or thirst, change in how much or how often you urinate, unusual weight loss
  • Numbness or weakness in your arm or leg, or on one side of your body
  • Pain in your lower leg (calf)
  • Sudden or severe headache, problems with vision, speech, or walking
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or diabetes.
  • This medicine may cause high blood sugar.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is sucralfate used for?
Sucralfate is FDA-approved for the short-term treatment (up to 8 weeks) of active duodenal ulcers and, at a lower dose, to help prevent duodenal ulcers from returning after they heal. It works by forming a protective barrier over the ulcer rather than by reducing stomach acid. Providers also use it for other conditions at their discretion, but you should follow the specific reason your own prescriber gave you.
How long does sucralfate take to work?
Sucralfate begins forming its protective coating over the ulcer soon after you take it, but healing an ulcer takes time. Treatment courses for active duodenal ulcers commonly run up to 8 weeks. Keep taking it exactly as directed for the full course, even if you start feeling better sooner, and talk to your provider if your symptoms do not improve.
Should sucralfate be taken on an empty stomach?
Yes. Sucralfate is taken on an empty stomach so the medicine can form its protective barrier directly on the ulcerated tissue. It is usually dosed before meals and at bedtime. Follow the exact timing on your prescription label, and avoid taking antacids within 30 minutes of your sucralfate dose.
What are the most common side effects of sucralfate?
The most common side effect is constipation. Because sucralfate contains aluminum, it should be used cautiously in people with chronic kidney disease or on dialysis. Rare reports include an aluminum-containing mass (bezoar), allergic reactions mainly with the oral suspension, and higher blood sugar in some people with diabetes. Contact your provider about any side effect that concerns you.
Can you take sucralfate and omeprazole together?
Providers sometimes prescribe sucralfate and omeprazole together because they work in different ways. If you take both, ask your pharmacist about spacing the doses, since sucralfate can bind other medicines in the gut and reduce their absorption. Always confirm the exact timing and plan with your own prescriber or pharmacist.
How much does Sucralfate cost without insurance?
The price of Sucralfate without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 86% off retail prices with a free Rx.com coupon.
What are the common side effects of Sucralfate?
Common side effects of Sucralfate may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Chest pain, trouble breathing, coughing up blood, Increased hunger or thirst, change in how much or how often you urinate, unusual weight loss, Numbness or weakness in your arm or leg, or on one side of your body, Pain in your lower leg (calf). This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Sucralfate?
Generic versions may be available for Sucralfate. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Sucralfate on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Sucralfate?
The cheapest pharmacy for Sucralfate depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Sucralfate near you.

Sucralfate Coupons & Prices

Sucralfate 1GM

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Looking for a sucralfate coupon? Sucralfate is the low-cost generic version of Carafate, an FDA-approved prescription medicine that coats and protects duodenal ulcers so they can heal. Because it is a widely stocked generic, the cash price is already modest, but what you pay can still vary a lot from one pharmacy to the next. Rx.com compares prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see the current price and print a free discount coupon.

What is sucralfate and how does it work?

Sucralfate is a gastrointestinal (GI) mucosal protectant, a sucrose sulfate-aluminum complex sold under the brand name Carafate in the US (and Sulcrate in Canada). Unlike acid reducers, it does not lower the amount of acid your stomach makes. Instead, it works locally: in the acidic environment of the stomach it forms a sticky, paste-like barrier that clings to ulcerated tissue, shielding the raw area from acid, pepsin, and bile so healing can take place.

It is FDA-approved for the short-term treatment of active duodenal ulcers (up to 8 weeks) and, at a reduced dose, for maintenance therapy to help prevent duodenal ulcers from coming back after they have healed. Sucralfate is taken on an empty stomach so the protective coating can form directly on the ulcer.

Sucralfate cost and savings without insurance

Sucralfate is available as an FDA-approved generic, so it is typically one of the more affordable ulcer medicines, whether you have insurance or are paying cash. Even so, generic prices are not fixed. The same prescription can cost noticeably more at one pharmacy than at another down the street, which is exactly why comparing before you fill pays off.

There is no manufacturer copay savings card for generic sucralfate. Instead, Rx.com gives you a free discount coupon that works at the register at more than 60,000 pharmacies nationwide. Enter your ZIP above to see today's price near you, then show the coupon to your pharmacist. If you were prescribed brand-name Carafate, ask your prescriber or pharmacist whether the generic is appropriate, since it usually costs far less.

Sucralfate vs. other ulcer and reflux medicines

Sucralfate is unusual because it protects tissue locally rather than reducing stomach acid. Many people with ulcers or reflux are treated instead with acid-suppressing drugs, and some are prescribed a combination. Common alternatives your provider may discuss include:

  • Omeprazole and pantoprazole — proton pump inhibitors (PPIs) that strongly lower stomach acid.
  • Famotidine — an H2 blocker that reduces acid production.
  • Misoprostol — used to help protect the stomach lining in certain situations.

These medicines work in different ways, and the right choice depends on your diagnosis and history. Only your prescriber can decide which is best for you. Whatever you are prescribed, you can compare prices for it on Rx.com.

Sucralfate safety and drug interactions

Sucralfate has no boxed warning. The most common side effect is constipation. Because it contains aluminum, it should be used with caution in people with chronic kidney disease or on dialysis, since aluminum can build up over time. Rarely, an aluminum-containing mass called a bezoar has been reported, mainly in critically ill patients or those with delayed stomach emptying. Rare hypersensitivity or allergic reactions have been reported, chiefly with the oral suspension, and hyperglycemia (high blood sugar) has been reported in some people with diabetes.

Sucralfate can bind other medicines in the gut and reduce how well they are absorbed, including fluoroquinolone and tetracycline antibiotics, digoxin, levothyroxine, phenytoin, and warfarin. To avoid this, these drugs are usually separated from sucralfate by at least 2 hours, and antacids should not be taken within 30 minutes of a dose. This is general information, not medical advice, so review your full medication list and any kidney concerns with your provider or pharmacist.

Sources & accuracy

This Sucralfate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Sucralfate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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