Tri-Lo-Mili
Tri-Lo-Mili 28 Tablets
What is Tri-Lo-Mili?
Tri-Lo-Mili is a prescription combination birth control pill used to help prevent pregnancy. It contains norgestimate and ethinyl estradiol in a triphasic dosing schedule that also helps regulate menstrual cycles, reduce menstrual cramps, and may improve acne in some women.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Breast lumps, tenderness, pain, swelling, or discharge
Warnings
- Although you are using this medicine to prevent pregnancy, you should know that using this medicine while you are pregnant could harm the unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you had given birth within 4 weeks before you start using this medicine. Tell your doctor if you have inherited angioedema, cervical cancer, diabetes, epilepsy, gallbladder disease, migraine headaches, heart or blood vessel disease, high cholesterol, a history of chloasma gravidarum (skin discoloration of the face during pregnancy), or depression. Tell your doctor if you smoke or if you are having a surgery that requires inactivity for a long time.
- This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsLiver problems (including cancer or tumors)High blood pressureGallbladder diseaseHigh cholesterol or fats in the bloodIncreased risk of breast or cervical cancer
- This medicine may cause skin discoloration. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
- This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases.
Prescription savings · · · ·
What is Tri-Lo-Mili ?
Tri-Lo-Mili is a prescription combination birth control pill used to help prevent pregnancy. It contains norgestimate and ethinyl estradiol in a triphasic dosing schedule that also helps regulate menstrual cycles, reduce menstrual cramps, and may improve acne in some women.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Breast lumps, tenderness, pain, swelling, or discharge
- Sudden and severe stomach pain, nausea, vomiting, lightheadedness
- Chest pain or tightness, trouble breathing, coughing up blood
- Unusual or unexpected vaginal bleeding or heavy bleeding
- Dark urine or pale stools, loss of appetite, yellow skin or eyes
- Unusual sweating, fainting
- Yellow skin or eyes
- Numbness or weakness on one side of your body, pain in your lower leg (calf), sudden or severe headache, problems with vision, speech, or walking
- Vision loss, double vision
- Although you are using this medicine to prevent pregnancy, you should know that using this medicine while you are pregnant could harm the unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you had given birth within 4 weeks before you start using this medicine. Tell your doctor if you have inherited angioedema, cervical cancer, diabetes, epilepsy, gallbladder disease, migraine headaches, heart or blood vessel disease, high cholesterol, a history of chloasma gravidarum (skin discoloration of the face during pregnancy), or depression. Tell your doctor if you smoke or if you are having a surgery that requires inactivity for a long time.
- This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsLiver problems (including cancer or tumors)High blood pressureGallbladder diseaseHigh cholesterol or fats in the bloodIncreased risk of breast or cervical cancer
- This medicine may cause skin discoloration. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
- This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases.
- You might have spotting or irregular bleeding when you first take the pill.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- If you miss two periods in a row, call your doctor for a pregnancy test before you take any more pills.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Tri-Lo-Mili Coupons & Prices
Tri-Lo-Mili 28 Tablets
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Looking for a Tri-Lo-Mili coupon? Tri-Lo-Mili is a generic triphasic birth control pill (norgestimate and ethinyl estradiol) that is already low-cost, but the cash price can vary widely from one pharmacy to the next. Rx.com compares prices across more than 60,000 U.S. pharmacies so you can find today's lowest price near you. Enter your ZIP above to see current pricing and get a free discount coupon you can use at the pharmacy counter.
What is Tri-Lo-Mili and how does it work?
Tri-Lo-Mili is a combination oral contraceptive that contains two hormones: the progestin norgestimate and the estrogen ethinyl estradiol. It is FDA-approved to prevent pregnancy in females of reproductive potential. It is a "triphasic" pill, meaning the hormone dose changes across the cycle. Each active tablet delivers 0.025 mg of ethinyl estradiol, while the norgestimate steps up in three phases (0.180 mg, then 0.215 mg, then 0.250 mg). The pack also includes 7 inactive (reminder) tablets to complete the 28-day cycle.
Tri-Lo-Mili is a generic equivalent within the Ortho Tri-Cyclen Lo formulation family. Like other combination pills, it works mainly by preventing ovulation and by changing cervical mucus and the uterine lining to reduce the chance of pregnancy.
Tri-Lo-Mili cost without insurance and how to save
Tri-Lo-Mili is a generic, so it is already one of the lower-cost combination birth control options. Even so, the cash price without insurance can differ a lot depending on which pharmacy you use, which is exactly why comparing matters. There is no manufacturer savings card for this generic, but a free Rx.com discount coupon can lower the cash price at the counter.
Rx.com checks pricing across more than 60,000 pharmacies so you can see where it is cheapest near you. Prices change often and are shown live, so enter your ZIP above to see today's price and print or show your coupon at the pharmacy. Your coupon works whether or not you have insurance, and can sometimes beat an insurance copay.
Tri-Lo-Mili alternatives and equivalents
Tri-Lo-Mili is one of several interchangeable generics of the same triphasic norgestimate/ethinyl estradiol formulation. If your pharmacy is out of stock or another version is cheaper, these therapeutic equivalents are commonly available:
- Ortho Tri-Cyclen Lo (the reference brand)
- Tri-Lo-Sprintec
- Tri-Lo-Estarylla
- Tri-Lo-Marzia
- Tri-Sprintec and Sprintec (related norgestimate/ethinyl estradiol pills with a different dosing schedule)
Because pricing varies by pharmacy and by product, it is worth comparing coupons for each option. Ask your prescriber or pharmacist before switching brands, as they are not always dose-for-dose identical.
Safety, side effects, and who should not use it
Combination birth control pills carry important warnings. Cigarette smoking increases the risk of serious cardiovascular events, and Tri-Lo-Mili should not be used by women over 35 who smoke. There is an increased risk of blood clots, stroke, and heart attack, especially with smoking, obesity, high blood pressure, migraine with aura, or a history of clotting. It also should not be used by people with current or past breast cancer, liver tumors or liver disease, undiagnosed abnormal uterine bleeding, or during pregnancy. Tri-Lo-Mili does not protect against HIV or other sexually transmitted infections.
The most common side effects include nausea, headache, breast tenderness, irregular bleeding or spotting, mood changes, and fluid retention. This information is educational and is not medical advice. Talk with your doctor or pharmacist about your personal risk factors and any symptoms before starting or continuing this medication, and seek care right away for signs of a blood clot such as chest pain, severe leg pain, or sudden shortness of breath.
This Tri-Lo-Mili information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Tri-Lo-Mili on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.