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Sprintec 28 Disp Pack — prescription drug image

Sprintec 28

Sprintec 28 28 Tablets

Prescriptions & Refills
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What is Sprintec 28?

Mononessa is used to prevent pregnancy. There is currently no generic version of Mononessa available in the United States. On average, a supply of 168, 35 mcg-0.25 mg Mononessa oral tablet cost about $112. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.

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What is Sprintec 28 ?

Mononessa is used to prevent pregnancy. There is currently no generic version of Mononessa available in the United States. On average, a supply of 168, 35 mcg-0.25 mg Mononessa oral tablet cost about $112. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.
  • Nausea
  • Vomiting
  • Headache
  • Bloating
  • Breast tenderness
  • Swelling of the ankles/feet (fluid retention)
  • Weight change
  • Increased risk of blood clots, heart attack, and stroke
  • Elevated blood pressure
  • May not be suitable for women over 35 years old who smoke
  • Possible increased risk of cancer of the breast and cervix
  • Risk of liver tumors​
  • Not for use during pregnancy
  • Interaction with certain medications
Is Sprintec 28 a good birth control pill?
Sprintec 28 is a widely used, FDA-approved combination birth control pill and the generic of Ortho-Cyclen. When taken correctly every day, combination pills like this are a very effective way to prevent pregnancy. Whether it is the right choice for you depends on your health history and any conditions that make estrogen-containing pills unsafe, so discuss it with your provider. It does not protect against sexually transmitted infections.
What is the difference between Sprintec and Tri-Sprintec?
Sprintec is monophasic, so every active tablet contains the same dose of norgestimate and ethinyl estradiol. Tri-Sprintec is triphasic, meaning the progestin dose changes across three phases of the cycle. Both use the same two hormones and both prevent pregnancy; Sprintec is the generic of Ortho-Cyclen and Tri-Sprintec is the generic of Ortho Tri-Cyclen. Your prescriber chooses based on your needs.
Does Sprintec 28 help with acne?
Sprintec 28 itself is FDA-approved to prevent pregnancy. The norgestimate/ethinyl estradiol combination is FDA-approved to treat moderate acne under certain other brand formulations in females 15 and older who also want oral contraception, and providers sometimes prescribe combination pills off-label for acne. Any use for acne should be decided by your prescriber, not assumed from the label.
What are the side effects of Sprintec 28?
Common side effects of combination birth control pills can include nausea, breast tenderness, headache, spotting or breakthrough bleeding between periods, and mood changes. More serious but less common risks include blood clots, stroke, and heart attack, which is why the pill is not recommended for women over 35 who smoke. Contact your provider right away for symptoms like severe leg pain or swelling, chest pain, or sudden severe headache.
How long does it take for Sprintec to become effective?
How quickly Sprintec starts protecting against pregnancy depends on when in your cycle you begin and the start method your provider recommends. In some cases a backup method such as condoms is advised for the first several days. Follow the exact instructions your prescriber or the package labeling gives you, and ask your provider or pharmacist if you are unsure.
How much does Sprintec 28 cost without insurance?
The price of Sprintec 28 without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Sprintec 28?
Common side effects of Sprintec 28 may include: Nausea, Vomiting, Headache, Bloating, Breast tenderness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Sprintec 28?
Generic versions may be available for Sprintec 28. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Sprintec 28 on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Sprintec 28?
The cheapest pharmacy for Sprintec 28 depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Sprintec 28 near you.

Sprintec 28 Coupons & Prices

Sprintec 28 28 Tablets

Prescriptions & Refills
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Sprintec 28 Disp Pack — prescription drug image
Prescription
Sprintec 28 1 package (28 tablets), 0.25-35mg-mcg (1)
your area ·
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a Sprintec 28 coupon? Sprintec 28 is a low-cost generic combination birth control pill (norgestimate and ethinyl estradiol), the generic equivalent of Ortho-Cyclen. Because it is already a widely stocked generic, cash prices are modest, but they still vary a lot from one pharmacy to the next. Enter your ZIP above to compare today's Sprintec 28 price across more than 60,000 pharmacies and print or show a free discount coupon at the counter.

What is Sprintec 28 and how does it work?

Sprintec 28 is a monophasic combination oral contraceptive that contains two hormones: ethinyl estradiol (an estrogen) and norgestimate (a progestin). It is the generic version of Ortho-Cyclen, and closely related generics include MonoNessa, Estarylla, and Previfem. The 28-day pack holds 21 active tablets (0.25 mg norgestimate / 0.035 mg ethinyl estradiol) that each deliver the same hormone dose, plus 7 inert placebo tablets you take during the last week so you stay in the habit of taking one pill every day.

Sprintec 28 is FDA-approved to prevent pregnancy. It works mainly by stopping ovulation, and it also thickens cervical mucus and changes the uterine lining to make pregnancy less likely. It does not protect against HIV or other sexually transmitted infections.

Sprintec 28 cost and coupons without insurance

As an established generic, Sprintec 28 is one of the more affordable combination birth control pills, and many people pay cash for it rather than running it through insurance. Even so, the cash price for the same monthly pack can differ widely between pharmacies in the same town, so it pays to compare before you fill. Rx.com checks prices at more than 60,000 U.S. pharmacies so you can find the lowest one near you.

There is no brand manufacturer savings card for this generic, but our free discount coupon can lower the cash price at the pharmacy counter, no insurance required. Enter your ZIP above to see today's Sprintec 28 price at nearby pharmacies, then show the coupon on your phone or print it.

Sprintec 28 vs. Tri-Sprintec and other alternatives

Sprintec is a monophasic pill, meaning every active tablet has the same hormone dose. Tri-Sprintec is the triphasic version, where the progestin dose steps up over three phases of the cycle; it is the generic of Ortho Tri-Cyclen. Sprintec 28 itself is the generic of Ortho-Cyclen.

Other generics that use the same norgestimate/ethinyl estradiol combination include MonoNessa and Estarylla. These are therapeutically similar, so which one you receive often comes down to what your pharmacy stocks and the price. Your prescriber and pharmacist can help you decide, and you can compare cash prices for each on Rx.com.

Important safety information

Sprintec 28 carries a boxed warning that cigarette smoking increases the risk of serious cardiovascular problems from combination birth control pills. This risk goes up with age and with heavy smoking, so the pill should not be used by women over 35 who smoke. Combination pills also raise the risk of blood clots (including DVT and pulmonary embolism), stroke, and heart attack.

Do not use Sprintec 28 if you have a history of blood clots, certain cancers such as breast cancer, liver disease or tumors, uncontrolled high blood pressure, migraine with aura, or if you are or may be pregnant. Some medicines, including certain seizure drugs, rifampin, HIV protease inhibitors, and the herbal supplement St. John's wort, can make it less effective. This is general information, not medical advice. Tell your provider about your full health history and all medicines you take, and talk with them before starting or stopping this pill.

Sources & accuracy

This Sprintec 28 information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Sprintec 28 on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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