Trijardy Xr
Trijardy XR 12.5-2.5-1000MG
What is Trijardy Xr?
Trijardy XR is an oral medication used to manage blood sugar levels in adults with type 2 diabetes. It combines three active ingredients: empagliflozin, linagliptin, and metformin, which work together to improve glycemic control through various mechanisms. This extended-release formulation is taken once daily, promoting convenience and adherence to the treatment regimen.Side Effects
- Blistering, peeling, red skin rash, large, hard skin blisters
- Severe joint pain
- Rapid weight gain, swelling in your hands, ankles, or feet
Warnings
- This medicine may cause the following problems:Lactic acidosis (too much acid in the blood)Pancreatitis (swelling of the pancreas)Heart failureLow blood pressureKetoacidosis (high ketones and acid in the blood), which can be life-threateningKidney problemsIncreased risk of genital yeast or urinary tract infections (including pyelonephritis, urosepsis)Low blood sugar, when used with other diabetes medicinesIncreased risk for leg, toe, or midfoot amputationFournier's gangrene (skin or tissue damage of the area between the anus and genitals)Serious skin reactions
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you have kidney disease, liver disease, heart disease, heart failure, vitamin B12 deficiency, or a history of pancreas problems, genital yeast or urinary tract infections, leg problems (including amputation, blood vessel disease), or foot infection, sores, or ulcers. Tell your doctor if you are on a low-salt diet, if you drink alcohol, or if you are having surgery or other procedures that require fasting.
Prescription savings · · · ·
What is Trijardy Xr ?
Trijardy XR is an oral medication used to manage blood sugar levels in adults with type 2 diabetes. It combines three active ingredients: empagliflozin, linagliptin, and metformin, which work together to improve glycemic control through various mechanisms. This extended-release formulation is taken once daily, promoting convenience and adherence to the treatment regimen.- Blistering, peeling, red skin rash, large, hard skin blisters
- Severe joint pain
- Rapid weight gain, swelling in your hands, ankles, or feet
- Fast or trouble breathing, severe weakness, tiredness, or confusion
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Pain, tenderness, redness, or swelling of the area between the anus and genitals, fever
- Increased hunger, headache, shaking, trembling, sweating
- Pain, tenderness, sores or ulcers, or infections on the leg or foot
- Change in how much or how often you urinate, bloody urine, painful or difficult urination, lower back or side pain, chills
- Lightheadedness, dizziness, fainting
- Sudden and severe stomach pain, nausea, vomiting
- This medicine may cause the following problems:Lactic acidosis (too much acid in the blood)Pancreatitis (swelling of the pancreas)Heart failureLow blood pressureKetoacidosis (high ketones and acid in the blood), which can be life-threateningKidney problemsIncreased risk of genital yeast or urinary tract infections (including pyelonephritis, urosepsis)Low blood sugar, when used with other diabetes medicinesIncreased risk for leg, toe, or midfoot amputationFournier's gangrene (skin or tissue damage of the area between the anus and genitals)Serious skin reactions
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you have kidney disease, liver disease, heart disease, heart failure, vitamin B12 deficiency, or a history of pancreas problems, genital yeast or urinary tract infections, leg problems (including amputation, blood vessel disease), or foot infection, sores, or ulcers. Tell your doctor if you are on a low-salt diet, if you drink alcohol, or if you are having surgery or other procedures that require fasting.
- Do not breastfeed during treatment with this medicine.
- This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests. You may need to stop at least 3 days before surgery.
- Tell your doctor if you are pregnant, or planning to become pregnant. It is not safe to take this medicine during the second and third trimester of pregnancy. It could harm an unborn baby. If you have problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active.
Trijardy Xr Coupons & Prices
Trijardy XR 12.5-2.5-1000MG
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Looking for a Trijardy XR coupon? Trijardy XR is a once-daily brand-name tablet that combines three diabetes medicines — empagliflozin, linagliptin, and extended-release metformin — in one pill to help adults with type 2 diabetes control their blood sugar. There is no generic version yet, so the cash price can be high. Use the free Rx.com discount coupon to see what you would pay at pharmacies near you: enter your ZIP above to see today's price, then show the coupon at the counter.
What is Trijardy XR and how does it work?
Trijardy XR is a fixed-dose combination tablet used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes when treatment with all three of its ingredients is appropriate. It is not for type 1 diabetes and is not used to treat diabetic ketoacidosis. Each tablet packs three different classes of medicine that lower glucose in different ways:
- Empagliflozin — an SGLT2 inhibitor that helps the kidneys remove extra sugar through the urine. This component is also approved to lower the risk of cardiovascular death in adults with type 2 diabetes who have established heart disease.
- Linagliptin — a DPP-4 inhibitor that helps the body release more insulin after meals.
- Metformin (extended-release) — a biguanide that reduces the amount of sugar the liver makes and helps the body respond better to insulin.
Combining all three in one extended-release tablet can mean fewer pills each day. Your prescriber decides whether this exact combination is right for you.
Trijardy XR cost: manufacturer savings card vs. Rx.com cash coupon
The maker of Trijardy XR, Boehringer Ingelheim, offers an official manufacturer savings program on its website for eligible patients. Manufacturer cards like this are generally limited to people with commercial (private) insurance, and the terms, eligibility, and expiration vary — they usually cannot be used if you have Medicare, Medicaid, or other government coverage. If you qualify, that program may be your lowest cost, so it is worth checking directly on the manufacturer's site.
The free Rx.com cash coupon is different: it is a discount card, not insurance, so it works whether you are uninsured, on Medicare, or simply told the manufacturer card was declined. You can use it instead of insurance when the cash price is lower. Because Trijardy XR has no generic, prices vary a lot from pharmacy to pharmacy — enter your ZIP above to see today's price and compare pharmacies near you before you fill. Boehringer Ingelheim also runs a patient assistance program for those who qualify based on income and insurance status; ask your prescriber or the manufacturer about eligibility.
Is there a generic? Alternatives and related medicines
There is currently no FDA-approved generic substitute for Trijardy XR, so a generic is not the savings lever here — comparing cash prices with a coupon is. If cost is a concern, your prescriber may consider the individual components or related combinations, several of which do have generic options or their own savings programs. Related medicines include:
- Jardiance (empagliflozin alone)
- Tradjenta (linagliptin alone)
- Glyxambi (empagliflozin + linagliptin)
- Synjardy (empagliflozin + metformin)
- Jentadueto (linagliptin + metformin)
- metformin (available as a low-cost generic)
Never switch or combine diabetes medicines on your own — doses do not transfer one-for-one between products. Talk with your prescriber or pharmacist about which option fits your health and budget.
Safety and side effects
Trijardy XR carries a boxed warning for lactic acidosis, a rare but serious and potentially fatal buildup of acid in the blood that comes from the metformin component. The risk rises with reduced kidney function, low-oxygen states, serious infection, heavy alcohol use, dehydration, liver problems, or when contrast dye is used for imaging. Get emergency care and stop the medicine if you have symptoms such as unusual muscle pain, trouble breathing, unusual sleepiness, or stomach pain with nausea. Trijardy XR should not be used if your kidney function (eGFR) is persistently below 30, if you have acute or chronic metabolic acidosis, or if you are allergic to any of its ingredients.
Other important risks noted on the label include diabetic ketoacidosis (which can happen even when blood sugar looks near normal), dehydration with low blood pressure and possible acute kidney injury, serious urinary tract infections, genital yeast infections, a rare but serious infection of the genital area (Fournier's gangrene), low blood sugar when taken with insulin or sulfonylureas, pancreatitis, allergic reactions, a blistering skin condition, joint pain, and long-term vitamin B12 deficiency from metformin. This is not a complete list and is not medical advice — read the label and talk with your prescriber or pharmacist about your personal risks.
This Trijardy Xr information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Trijardy Xr on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.