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Urea

Urea 28.35GM of 40%

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What is Urea?

Urea, also known as carbamide, is an organic compound with the chemical formula (NH2)2CO. It is used in pharmaceutical preparations as a keratolytic agent, helping to hydrate and exfoliate the skin by increasing moisture content and breaking down hard skin cells. Urea is widely incorporated into topical creams, ointments, and lotions to treat dry, rough, and scaly skin conditions such as eczema, psoriasis, and ichthyosis.

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What is Urea ?

Urea, also known as carbamide, is an organic compound with the chemical formula (NH2)2CO. It is used in pharmaceutical preparations as a keratolytic agent, helping to hydrate and exfoliate the skin by increasing moisture content and breaking down hard skin cells. Urea is widely incorporated into topical creams, ointments, and lotions to treat dry, rough, and scaly skin conditions such as eczema, psoriasis, and ichthyosis.
  • Local irritation (redness, itching, burning sensation)
  • Skin rash
  • Avoid contact with eyes, lips, or mucous membranes
  • Not recommended for use on broken or severely irritated skin
What is urea cream used for?
Urea cream is used to soften and moisturize dry, rough, thick, or scaly skin. It is used for conditions like xerosis, ichthyosis, keratosis pilaris, corns, calluses, dermatitis, eczema, and psoriasis. Higher prescription strengths are also used to help remove and heal very thick, hardened surface lesions and to treat damaged or thickened nails.
Is urea cream available over the counter or by prescription?
Both. Lower strengths of about 10 to 20 percent are widely available over the counter as moisturizers, while higher strengths (such as 40 to 50 percent) are prescription products used for thicker, hardened skin and nail conditions. Your pharmacist can help you find the right option.
What is the difference between 10%, 20%, 40%, and 45% urea cream?
The percentage refers to how much urea is in the product, which affects how strongly it works. Lower strengths (10 to 20 percent) mainly moisturize dry skin and are usually sold over the counter. Higher strengths (40 to 50 percent, including 45 percent) are prescription products used to soften and remove very thick, hardened skin and to treat damaged nails. Your provider can advise which strength is appropriate for you.
Does urea cream have side effects?
The most common side effects are local and usually temporary, such as stinging, burning, itching, redness, or irritation, especially on broken or inflamed skin. Rarely, an allergic reaction can occur, with signs like rash, hives, swelling of the face, lips, or tongue, or trouble breathing. Stop use and seek medical care if that happens. Urea is for external use only and should be kept away from the eyes, lips, and mucous membranes.
Can urea cream be used on nails or feet?
Yes. Urea is commonly used on the feet for thick, dry, or hardened skin such as corns and calluses, and higher-strength prescription products are used on thickened, damaged, or ingrown nails, including for chemical nail removal. Follow your provider's or product's directions, and keep it out of your eyes and off mucous membranes.
How much does Urea cost without insurance?
The price of Urea without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 72% off retail prices with a free Rx.com coupon.
What are the common side effects of Urea?
Common side effects of Urea may include: Local irritation (redness, itching, burning sensation), Skin rash. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Urea?
Generic versions may be available for Urea. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Urea on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Urea?
The cheapest pharmacy for Urea depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Urea near you.

Urea Coupons & Prices

Urea 28.35GM of 40%

Prescriptions & Refills
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Urea Bottle — prescription drug image
Prescription
Urea 28.35gm of 40% (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Urea prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
227gm of 41% · Bottle 227 $705.99 $559.99

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a urea coupon? Urea is a widely available generic topical medication, sold under brand names like Utopic, Umecta, Keralac, Carmol, and Nutraplus, and because it is generic it is already one of the more affordable skin treatments. Even so, the cash price can vary a lot from one pharmacy to the next, so it pays to compare. Rx.com checks prices across more than 60,000 pharmacies so you can find a low price near you. Enter your ZIP above to see today's price on urea and print or show your free coupon at the pharmacy counter.

What is urea and how does it work?

Urea (topical) is a keratolytic emollient, which means it works two ways at once: it draws and holds moisture in the skin (a humectant) and helps soften and break down thick, hardened, or scaly skin. It is used to moisturize and smooth dry, rough, thick, or scaly skin. Lower strengths of 10 to 20 percent are commonly sold over the counter as everyday moisturizers, while higher prescription strengths (for example 40 to 50 percent) are used to help remove and heal very thick, hardened surface lesions, including where healing is slowed by local infection, dead tissue, or crusting.

It is often used, both on-label and off-label, for hyperkeratotic and very dry (xerotic) skin conditions such as xerosis, ichthyosis, keratosis pilaris, corns, calluses, dermatitis, eczema, and psoriasis, as well as for thickened, damaged, or ingrown nails. This is general information, not medical advice; your provider or pharmacist can help you choose the right strength for your situation.

Urea cost without insurance and how to save

Because urea is available as a generic, it is already a lower-cost option compared with many brand-name skin treatments. The catch is that the cash price without insurance is not the same everywhere. Different pharmacies set different prices for the same strength and tube size, so two stores in the same town can charge very different amounts. That is exactly why comparing before you fill matters.

Rx.com compares urea prices across more than 60,000 pharmacies and shows you a free coupon you can use with or without insurance. There is no manufacturer savings card for generic urea, so a pharmacy-price coupon is usually the most practical way to keep the cost down. Enter your ZIP above to see today's price near you, then bring the coupon to the counter.

Urea alternatives and related treatments

Urea is one of several topical options for dry, thick, or scaly skin, and the right choice depends on your skin and your provider's guidance. Other keratolytic or moisturizing treatments people compare with urea include salicylic acid, ammonium lactate, and lactic acid. For certain conditions, providers may instead prescribe tretinoin or, for plaque psoriasis, calcipotriene.

These medicines work in different ways and are not interchangeable, so talk with your provider or pharmacist about which fits your needs. Whichever one you and your provider choose, you can check and compare its price on Rx.com.

Urea safety and side effects

Urea is for external, topical use only. Avoid getting it in your eyes, on your lips, or on other mucous membranes. The most common effects are local and usually temporary, including stinging, burning, itching, redness, or irritation, and these are more likely on broken or inflamed skin. Do not apply it to open wounds beyond its intended debridement use unless your provider directs you to. There is no boxed warning for topical urea.

Rarely, an allergic reaction can occur. Stop using it and seek medical care if you notice a rash, hives, swelling of the face, lips, or tongue, or trouble breathing. This is general information and not a substitute for medical advice, so follow the product instructions and check with your provider or pharmacist with any questions.

Sources & accuracy

This Urea information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Urea on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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