Xifaxan Coupons & Prices

Looking for a Xifaxan coupon? Xifaxan (rifaximin) is a brand-name, gut-selective antibiotic used to treat irritable bowel syndrome with diarrhea (IBS-D), to lower the risk of overt hepatic encephalopathy coming back, and to treat travelers' diarrhea caused by certain E. coli strains. There is no generic version yet, so it can be costly, and a free Rx.com cash coupon may lower your out-of-pocket cost at the pharmacy. Enter your ZIP above to see today's price at pharmacies near you.

What is Xifaxan and how does it work?

Xifaxan is the brand name for rifaximin, a rifamycin-class antibiotic. Unlike most antibiotics, it is considered non-systemic or "gut-selective," meaning very little is absorbed into the bloodstream and it works mainly inside the intestines. This makes it useful for gut-related conditions.

The FDA has approved Xifaxan for three uses in adults (with travelers' diarrhea also approved for children 12 and older): treating IBS-D (550 mg three times daily for 14 days, which may be repeated up to two more times if symptoms return), reducing the risk of overt hepatic encephalopathy recurrence (550 mg twice daily), and treating travelers' diarrhea caused by noninvasive strains of E. coli (200 mg three times daily for 3 days). It is not intended for diarrhea that comes with fever or blood in the stool, or that is caused by germs other than E. coli.

Xifaxan cost: manufacturer savings card vs. Rx.com cash coupon

Because Xifaxan has no generic equivalent, it is a brand-only drug and prices can be high. There are two main ways to save. The maker of Xifaxan offers a manufacturer savings card, but these cards are generally limited to people with commercial (private) insurance and typically exclude those with Medicare, Medicaid, or no insurance. Terms and eligibility vary, so check the official page for current details.

If you are uninsured, on Medicare, or the manufacturer card is declined, a free Rx.com cash coupon is an alternative you can use instead. It is not insurance; it is a discount applied at the register. Enter your ZIP above to see today's price and the pharmacies near you. The manufacturer also runs patient-assistance resources for eligible patients, so it can be worth asking your provider or the manufacturer program about those options as well.

Alternatives and related medications

Because Xifaxan has no generic yet, cost is a common reason people ask about other options. The active ingredient is also discussed under its own name, rifaximin. For IBS-D specifically, your doctor may consider other prescription treatments such as Viberzi (eluxadoline), Amitiza (lubiprostone), or, for related IBS symptoms, Linzess (linaclotide) and Trulance (plecanatide).

For hepatic encephalopathy, lactulose is a commonly used option, and Xifaxan is often added on top of it. These medicines work differently and are not interchangeable, so only your provider can decide what fits your condition. This is general information, not medical advice.

Safety and side effects

Xifaxan has no boxed warning. It should not be used for travelers' diarrhea that comes with fever or bloody stool, or that is caused by germs other than E. coli; if diarrhea gets worse or lasts beyond 24 to 48 hours, stop and talk to your provider. As with nearly all antibiotics, Clostridioides difficile-associated diarrhea (ranging from mild diarrhea to serious colitis) has been reported. Xifaxan should not be taken by anyone allergic to rifaximin, other rifamycin antibiotics, or any ingredient in the product.

Use extra caution if you have severe liver impairment (Child-Pugh C), since more of the drug can build up in the body. Some medicines, such as cyclosporine, can raise rifaximin levels through a drug interaction, so share your full medication list with your provider. In pregnancy, the benefits and risks should be weighed with your doctor. This is not a complete list of precautions, and it is not medical advice, so please talk with your healthcare provider or pharmacist about your situation.