Zonisamide
Zonisamide 100MG
What is Zonisamide?
Zonegran is used together with other medications to treat partial seizures in adults with epilepsy. The generic version of Zonegran is Zonisamide. The average price of Zonegran is around $1,156 for 100, 25 mg capsules. Use our Rx.com savings offer to get great discounts on Zonegran at participating pharmacies near you.Side Effects
- Depression, unusual changes in moods or behavior, thoughts of hurting yourself or others
- Painful or difficult urination, bloody urine, change in how much you urinate, sudden and severe back or stomach pain
- Swollen, painful, or tender lymph glands in neck, armpit, or groin
Warnings
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. Your seizures may increase if you stop taking this medicine suddenly.
- This medicine may make you sweat less and cause your body temperature to increase. Use caution when you exercise or if you are outside in hot weather.
- Drink extra fluids so you will urinate more often and help prevent kidney problems.
Prescription savings · · · ·
What is Zonisamide ?
Zonegran is used together with other medications to treat partial seizures in adults with epilepsy. The generic version of Zonegran is Zonisamide. The average price of Zonegran is around $1,156 for 100, 25 mg capsules. Use our Rx.com savings offer to get great discounts on Zonegran at participating pharmacies near you.- Depression, unusual changes in moods or behavior, thoughts of hurting yourself or others
- Painful or difficult urination, bloody urine, change in how much you urinate, sudden and severe back or stomach pain
- Swollen, painful, or tender lymph glands in neck, armpit, or groin
- Blistering, peeling, red skin rash
- Sore throat, sores or ulcers in the mouth or on the lips, easy bruising
- Blurred or changes in vision
- Fast breathing, loss of appetite, unusual tiredness, fast, pounding, or uneven heartbeat
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Confusion, problems with speech, coordination, concentration, or memory
- Fever, decreased sweating
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. Your seizures may increase if you stop taking this medicine suddenly.
- This medicine may make you sweat less and cause your body temperature to increase. Use caution when you exercise or if you are outside in hot weather.
- Drink extra fluids so you will urinate more often and help prevent kidney problems.
- This medicine may make you dizzy, drowsy, or tired. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Talk with your doctor before using this medicine if you plan to have children. Some women who use this medicine have become infertile (unable to have children).
- This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.
- This medicine may cause the following problems:Serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysisDrug reaction with eosinophilia and systemic symptoms (DRESS), which may involve multiple organs, including your liver or kidneysEye or vision problems, including acute myopia, glaucomaChanges in mood or behavior, including suicidal thoughts or behaviorMetabolic acidosis (too much acid in your blood)Problems with concentration, attention, memory, thinking, speech, or languageHyperammonemia (too much ammonia in your blood), which may damage the brain and can be life-threateningKidney stones
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, breathing or lung problems, bone problems (including osteomalacia, osteopenia, osteoporosis), or a history of depression or metabolic acidosis.
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control during treatment with this medicine and for at least 1 month after the last dose.
Zonisamide Coupons & Prices
Zonisamide 100MG
Weight-loss medication, prescribed online
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Looking for a zonisamide coupon? Zonisamide (the generic form of Zonegran) is a low-cost anticonvulsant, but the cash price still varies widely from one pharmacy to the next, so it pays to compare before you fill. Enter your ZIP above to see today's zonisamide price and print a free Rx.com discount coupon you can use at the pharmacy counter, with no insurance required.
What is zonisamide and how does it work?
Zonisamide is an antiseizure (anticonvulsant) medicine sold under the brand names Zonegran and Zonisade. It is a sulfonamide-derived drug that also acts as a carbonic anhydrase inhibitor. It is FDA-approved as adjunctive (add-on) therapy for partial seizures in adults and children 16 years and older who have epilepsy, meaning it is taken alongside other seizure medicines rather than on its own.
Zonisamide is available as an FDA-approved generic, which is one reason it is often more affordable than newer branded options. Your prescriber decides the dose and how it fits into your overall treatment plan. This information is not medical advice, so talk with your doctor or pharmacist about how zonisamide works for your situation.
How much does zonisamide cost without insurance?
Because zonisamide is available as a generic, it is generally one of the lower-cost seizure medicines, but the cash price without insurance can still swing a lot depending on which pharmacy you choose, your dose, and your location. Two pharmacies on the same street can list very different prices for the exact same prescription, so comparing is the single best way to save.
Rx.com compares zonisamide prices across more than 60,000 pharmacies nationwide and shows you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you, then bring the coupon to the counter. If you were prescribed the brand name, you can also compare zonisamide generic pricing to see the difference.
Zonisamide alternatives and related seizure medicines
Zonisamide is one of several antiseizure medicines used as add-on therapy for partial seizures. Which one is right depends on your seizure type, other health conditions, side effects, and cost. Only your prescriber can decide whether a different medicine is appropriate, but it can help to compare pricing on related options:
Never switch or stop a seizure medicine on your own. Enter your ZIP above to compare prices on any of these at pharmacies near you.
Zonisamide safety and common side effects
Zonisamide has no boxed warning, but it does carry important safety information. Because it is a sulfa-derived drug, it should not be used by people with a known allergy to sulfonamides. The FDA label warns about serious skin reactions (including Stevens-Johnson syndrome and toxic epidermal necrolysis) and a multi-organ hypersensitivity reaction called DRESS, as well as metabolic acidosis (your doctor may check your bicarbonate levels), decreased sweating and overheating (especially in children), kidney stones, acute nearsightedness with increased eye pressure (glaucoma), and cognitive or mood changes. Like other antiseizure drugs, it also carries a class-wide warning about suicidal thoughts and behavior. Do not stop taking zonisamide abruptly, because that can trigger seizures.
Common side effects include drowsiness, dizziness, loss of appetite, unsteadiness (ataxia), agitation or irritability, and trouble with memory or concentration. This is a summary and not a complete list. Call your doctor about any reaction that worries you, and always consult your provider before making changes to your medication.
This Zonisamide information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Zonisamide on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.