Combipatch
CombiPatch
What is Combipatch?
CombiPatch (estradiol/norethindrone acetate) is a prescription hormone replacement therapy (HRT) patch used to treat moderate to severe menopause symptoms, including hot flashes and night sweats. It combines estrogen and progestin to help relieve symptoms while protecting the uterine lining in women who have not had a hysterectomy.
Side Effects
- Unusual or unexpected vaginal bleeding or heavy bleeding
- Swelling in your hands, ankles, or feet
- Sudden or severe stomach pain, nausea, or vomiting
Warnings
- Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.
- Tell your doctor if you are breastfeeding or if you have kidney disease, heart disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, porphyria, lupus, an underactive thyroid, high blood pressure, or high cholesterol. Tell your doctor if you have ever had liver problems caused by pregnancy or estrogen, or if you smoke.
- Do not use this medicine if you had a hysterectomy.
- This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsIncreased risk of endometrial cancer, breast cancer, or uterine cancerIncreased risk of dementia, especially in women 65 years of age and olderGallbladder disease
- You may need to stop using this medicine for a few weeks before and after you have surgery or if you need to be on bedrest, because of the risk of blood clots.
Prescription savings · · · ·
What is Combipatch ?
CombiPatch (estradiol/norethindrone acetate) is a prescription hormone replacement therapy (HRT) patch used to treat moderate to severe menopause symptoms, including hot flashes and night sweats. It combines estrogen and progestin to help relieve symptoms while protecting the uterine lining in women who have not had a hysterectomy.
- Unusual or unexpected vaginal bleeding or heavy bleeding
- Swelling in your hands, ankles, or feet
- Sudden or severe stomach pain, nausea, or vomiting
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain that may spread, trouble breathing, nausea, unusual sweating, fainting
- Chest pain, trouble breathing, or coughing up blood
- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
- Vision changes, vision loss, double vision, migraine headache
- Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.
- Tell your doctor if you are breastfeeding or if you have kidney disease, heart disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, porphyria, lupus, an underactive thyroid, high blood pressure, or high cholesterol. Tell your doctor if you have ever had liver problems caused by pregnancy or estrogen, or if you smoke.
- Do not use this medicine if you had a hysterectomy.
- This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsIncreased risk of endometrial cancer, breast cancer, or uterine cancerIncreased risk of dementia, especially in women 65 years of age and olderGallbladder disease
- You may need to stop using this medicine for a few weeks before and after you have surgery or if you need to be on bedrest, because of the risk of blood clots.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. You should have regular pelvic exams, breast exams, and mammograms as directed by your doctor.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Vision changes, vision loss, double vision, migraine headache
Combipatch Coupons & Prices
CombiPatch
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Looking for a CombiPatch coupon? CombiPatch is a brand-name transdermal (skin patch) form of hormone replacement therapy that combines two hormones, estradiol (an estrogen) and norethindrone acetate (a progestin), to treat moderate-to-severe menopause symptoms such as hot flashes and vaginal dryness. Because there is no generic version yet, the price can be high, so it pays to compare your options. Enter your ZIP above to see today's Rx.com cash price at pharmacies near you, and read below to understand how our cash coupon compares with the manufacturer's savings card.
What is CombiPatch and how does it work?
CombiPatch is a combination hormone replacement therapy (HRT) delivered through the skin. It contains estradiol, a form of estrogen, and norethindrone acetate, a progestin. It is FDA-approved to treat moderate-to-severe hot flashes (vasomotor symptoms) due to menopause, moderate-to-severe symptoms of vulvar and vaginal atrophy (such as dryness) due to menopause, and low estrogen (hypoestrogenism) caused by hypogonadism, castration, or primary ovarian failure.
The patch is applied to the lower abdomen and changed twice a week (every 3 to 4 days) over a 28-day cycle. In women who still have a uterus, the progestin (norethindrone) component is included to help protect the lining of the uterus (the endometrium), because taking estrogen alone can raise the risk of endometrial hyperplasia and cancer. Your provider will decide whether CombiPatch is right for you and at what dose.
Manufacturer savings card vs. Rx.com cash coupon
The maker of CombiPatch offers a manufacturer savings card that may lower your out-of-pocket cost. Like most brand-name copay cards, it is generally limited to people with commercial (private) insurance and typically cannot be used if you are uninsured or have government coverage such as Medicare or Medicaid. Terms, eligibility, and any limits vary and can change, so check the official offer at combipatch.com/myoffer.php.
An Rx.com cash coupon works differently. It is a discount you can use even when the manufacturer card does not apply, for example if you are uninsured, on Medicare, or if the copay card is declined at the pharmacy. You do not use insurance with a cash coupon, so it is worth comparing both. Enter your ZIP above to see today's Rx.com price at pharmacies near you, then compare it against your insurance copay or the manufacturer card to see which is lowest for you.
Is there a generic, and what are the alternatives?
There is currently no generic version of CombiPatch, so a lower-cost generic is not yet a savings option. Other hormone therapy products contain the same or similar hormones and may be alternatives your provider could consider. These include patches like Climara Pro (another estrogen-plus-progestin transdermal system) and oral combination products such as Activella and its generic estradiol / norethindrone. Estrogen-only estradiol is another related option, though estrogen alone is generally not used in women who still have a uterus without adding a progestin.
Which product fits you depends on your symptoms, whether you have a uterus, your health history, and cost. This is not medical advice, so talk with your provider or pharmacist about the best and most affordable choice for your situation.
Safety and important warnings
CombiPatch carries the FDA boxed warnings that apply to estrogen-plus-progestin therapy. In the Women's Health Initiative (WHI) study, estrogen plus progestin was linked to increased risks of stroke, deep vein thrombosis, pulmonary embolism, heart attack, invasive breast cancer, and probable dementia in women 65 and older. Estrogen use also raises the risk of endometrial cancer, which is why the progestin component is added for women with a uterus. CombiPatch should not be used to prevent heart disease or dementia, and the general guidance is to use the lowest effective dose for the shortest time needed.
CombiPatch should not be used if you have undiagnosed abnormal vaginal bleeding, known or suspected breast cancer or another estrogen-dependent cancer, a current or past blood clot or clotting disorder (such as stroke, heart attack, DVT, or PE), liver disease or impairment, or known or suspected pregnancy. It is not for use during pregnancy. This is a summary, not medical advice. Review your full history and all risks and benefits with your provider before starting or continuing CombiPatch.
This Combipatch information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Combipatch on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.