Estradiol-Norethindrone Acet Coupons & Prices

Looking for an estradiol/norethindrone acetate coupon? This combination hormone tablet is a menopausal hormone therapy that treats hot flashes, night sweats, and vaginal changes in women who still have their uterus, and it is available as a low-cost FDA-approved generic (brand versions include Activella, Amabelz, Mimvey, and Lopreeza). Even so, the cash price can vary a lot from one pharmacy to the next, so comparing before you fill matters. Enter your ZIP above to see today's price at pharmacies near you. Rx.com compares prices across more than 60,000 U.S. pharmacies so you can find a lower cash price without insurance.

What is estradiol/norethindrone acetate and how does it work?

Estradiol/norethindrone acetate is a once-daily tablet that combines two hormones: estradiol, a form of estrogen, and norethindrone acetate, a progestin. It is a type of menopausal hormone therapy. The estrogen replaces some of the hormone the ovaries stop making after menopause, which eases moderate to severe hot flashes, night sweats, and moderate to severe vulvar and vaginal atrophy (dryness, irritation, and discomfort). The higher-strength tablet (1 mg/0.5 mg, sold as Activella and Mimvey) is also approved to help prevent postmenopausal osteoporosis; when bone protection is the only goal, non-estrogen options should be considered first.

The norethindrone (progestin) part is included for an important reason: in a woman who still has her uterus, estrogen taken alone can overgrow the uterine lining and raise the risk of endometrial cancer. Adding the progestin protects the lining and lowers that risk. This is why this combination product, rather than estrogen alone, is prescribed for women with an intact uterus.

Cost and savings: comparing pharmacies without insurance

Estradiol/norethindrone acetate is available as an FDA-approved generic, which is generally much less expensive than the brand-name versions. But "generic" does not mean the same price everywhere. The cash price for the identical tablet can differ widely between two pharmacies in the same town, so it pays to compare before you fill. There is no manufacturer copay savings card for this generic, so a pharmacy price comparison is usually the most reliable way to lower your out-of-pocket cost.

Enter your ZIP above to see today's price and a free Rx.com coupon you can show at the pharmacy counter. The coupon is for cash-paying customers and does not require insurance. If your insurance or Medicare plan covers the medication, compare the coupon price to your copay and use whichever is lower. Rx.com checks prices across more than 60,000 U.S. pharmacies so you can see where this drug is cheapest near you.

Related and alternative hormone therapies

The brand-name equivalents of this generic include Activella, Amabelz, Mimvey, and Lopreeza, which contain the same two active ingredients. If your prescription is written for a brand, ask your pharmacist whether the substitutable generic is available at a lower price. You can compare the brand and generic here: Activella and Mimvey.

Other menopause hormone options work differently and may suit different needs. Estradiol alone is often used by women who have had a hysterectomy and do not need the added progestin. Norethindrone is the progestin component on its own. Some women use an estradiol/progesterone combination instead. There is no single best choice; the right therapy depends on your symptoms, your health history, and whether you still have your uterus. Your provider can help you weigh the options.

Safety and important warnings

This is not medical advice, and you should discuss your personal risks with your provider. Estrogen-plus-progestin therapy carries an FDA boxed warning: it can increase the risk of stroke, blood clots in the legs or lungs (DVT and pulmonary embolism), heart attack, and invasive breast cancer, and in women 65 and older it may increase the risk of probable dementia. It also carries a risk of endometrial cancer, though the progestin lowers that risk. Because of these risks, it should not be used to prevent heart disease or dementia, and the guidance is to use the lowest effective dose for the shortest time needed to meet your goals, reviewed regularly with your provider.

Estradiol/norethindrone acetate should not be used if you have undiagnosed abnormal vaginal bleeding; a known, suspected, or past history of breast cancer or other estrogen-dependent cancer; a current or past blood clot (DVT or PE) or arterial clotting event such as stroke or heart attack; liver disease or impairment; a known clotting (thrombophilic) disorder; or if you are or may be pregnant. Tell your provider your full health history and report any warning signs such as chest pain, sudden shortness of breath, leg swelling, vision changes, severe headache, or unusual vaginal bleeding right away.