Butalbital-Apap-Caffeine
Butalbital-APAP-Caffeine 50-325-40MG
What is Butalbital-Apap-Caffeine?
Butalbital APAP Caffeine, also known as Floricet and is used to treat a certain type of headache (tension). The generic version of Fioricet is acetaminophen/butalbital/caffeine.
The average Fioricet price is about $190 for a supply of 30, 300mg-50 mg-40 mg capsules. You can use our Rx.com coupon to get an average Fioricet discount of up to 80% off of the retail price at participating pharmacies near you.
If you're needing a new prescription or a refill for Floricet, Rx.com can facilitate an online visit in a matter of minutes.
Side Effects
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Extreme dizziness or weakness, trouble breathing, slow heartbeat, seizures, and cold, clammy skin
- Blistering, peeling, red skin rash
Warnings
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or stomach problems. Tell your doctor if you have a history of alcohol or drug addiction.
- This medicine may cause the following problems:Liver damageSerious skin reactions
- This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
Prescription savings · · · ·
What is Butalbital-Apap-Caffeine ?
Butalbital APAP Caffeine, also known as Floricet and is used to treat a certain type of headache (tension). The generic version of Fioricet is acetaminophen/butalbital/caffeine.
The average Fioricet price is about $190 for a supply of 30, 300mg-50 mg-40 mg capsules. You can use our Rx.com coupon to get an average Fioricet discount of up to 80% off of the retail price at participating pharmacies near you.
If you're needing a new prescription or a refill for Floricet, Rx.com can facilitate an online visit in a matter of minutes.
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Extreme dizziness or weakness, trouble breathing, slow heartbeat, seizures, and cold, clammy skin
- Blistering, peeling, red skin rash
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Lightheadedness, dizziness, fainting
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or stomach problems. Tell your doctor if you have a history of alcohol or drug addiction.
- This medicine may cause the following problems:Liver damageSerious skin reactions
- This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Butalbital-Apap-Caffeine Coupons & Prices
Butalbital-APAP-Caffeine 50-325-40MG
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Butalbital-Apap-Caffeine prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 50-300-40mg · Capsule | 30 | $83.99 | $23.35 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a butalbital-apap-caffeine coupon? This generic combination of butalbital, acetaminophen, and caffeine (sold under brand names like Fioricet and Esgic) is already a lower-cost generic, but the cash price can vary widely from one pharmacy to the next, so comparing before you fill matters. Rx.com compares prices across more than 60,000 pharmacies so you can find a low price near you. Enter your ZIP above to see today's price at pharmacies near you.
What is butalbital / acetaminophen / caffeine and how does it work?
Butalbital / acetaminophen / caffeine is a three-drug combination approved by the FDA to relieve the symptom complex of tension (or muscle contraction) headache. According to the FDA prescribing information, the role each of the three ingredients plays in relieving tension headache is incompletely understood. In general terms: acetaminophen is a pain reliever and fever reducer; butalbital is a short- to intermediate-acting barbiturate, a medicine that has a calming, sedating effect on the brain and central nervous system; and caffeine is a central nervous system stimulant. It belongs to the drug class of barbiturate analgesic combinations.
It is sometimes used off-label for migraine headache, but it is not a first-line migraine treatment and is generally discouraged for that use because of the risk of medication-overuse (rebound) headache and dependence. Talk with your provider about whether this medication is right for you. This information is educational and is not a substitute for medical advice.
Butalbital-apap-caffeine cost and savings without insurance
The generic form of butalbital / acetaminophen / caffeine is widely available and is typically an affordable, low-cost option compared with brand-name versions like Fioricet or Esgic. Even so, the cash price you pay can differ significantly depending on which pharmacy you use, which is exactly why comparing prices is worthwhile. There is no manufacturer savings card for this generic, but an Rx.com coupon can help you pay a lower cash price whether or not you have insurance.
To see honest, up-to-date pricing, enter your ZIP above to see today's price. Rx.com checks more than 60,000 pharmacies so you can compare what each one charges and pick the best deal near you.
Alternatives and related medications
If you and your provider are weighing other options, several related medications are commonly discussed for headache and migraine. These include:
- Fioricet - the best-known brand name for this same butalbital / acetaminophen / caffeine combination
- Fiorinal - a related combination that uses aspirin instead of acetaminophen
- butalbital-apap-caffeine-codeine - the same combination with added codeine
- acetaminophen - the non-opioid pain reliever used in this combination
- sumatriptan and rizatriptan - triptan medications used specifically for migraine attacks
Only your healthcare provider can determine which of these is appropriate for you. Use the ZIP tool above to compare prices on any of these medications.
Important safety information
The acetaminophen in this combination carries a strong FDA warning about liver damage: do not exceed 4,000 mg of acetaminophen per day, because taking too much can cause severe, sometimes fatal liver damage that may require a transplant. This risk rises with alcohol use, and you should avoid taking it alongside other acetaminophen-containing products. Butalbital is a barbiturate that can be habit-forming, leading to dependence and tolerance; stopping it suddenly after prolonged use can cause serious withdrawal, including seizures, so any change should be guided by your provider. Overusing the medication for headaches can also cause medication-overuse (rebound) headache.
This medication can cause drowsiness and dizziness that impair driving, and it can be dangerously additive with alcohol, opioids, benzodiazepines, and other CNS depressants, raising the risk of slowed breathing and overdose. It should not be used by people with porphyria. Rare but serious skin reactions have been reported with acetaminophen. This is not a complete list of risks; talk with your doctor or pharmacist about your full medical history and other medications before starting this drug.
This Butalbital-Apap-Caffeine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Butalbital-Apap-Caffeine on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Butalbital-Apap-Caffeine — Articles & Guides
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.