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Prescription Peptide Therapy

Sermorelin Online: Your Own Growth Hormone, Restarted

Growth hormone output falls steadily with age. Sermorelin signals your pituitary to release more of its own, on your body's natural nightly rhythm. Prescribed online by U.S.-licensed providers and shipped to your door.

  • May support deeper sleep, energy and recovery
  • Works with your body, not a replacement hormone
  • One small injection at bedtime
  • 100% online visit, no clinic trips
See If You Qualify From $149/month · free shipping
Rx.com sermorelin vial

Compounded Sermorelin

Rx.com Sermorelin

3 mg/mL, 5 mL vial

from $149 /month

3-month plan, $447 upfront. Single month $179.

Start Your Online Visit About 1 minute. Billed only if prescribed.

What is sermorelin?

What is sermorelin? A peptide signal, not a substitute

Sermorelin is a peptide, a short chain of 29 amino acids, and a lab-made copy of the active part of growth hormone-releasing hormone (GHRH), the messenger your brain uses to tell the pituitary gland to release growth hormone. It was FDA approved in 1997 under the brand name Geref. That product was discontinued in 2008 for commercial reasons, and sermorelin is prescribed today as a compounded medication.

From your late 20s on, growth hormone output drops steadily, and by midlife it is a fraction of what it was. That decline is linked to lighter sleep, slower recovery, more midsection fat and less lean muscle. Sermorelin does not replace growth hormone. It prompts your pituitary to make more of its own, in natural pulses, with your body's built-in feedback still in control.

What people use sermorelin for

Growth hormone touches sleep, metabolism, muscle and tissue repair. These are the areas sermorelin is most often prescribed to support. Individual results vary.

Woman sleeping peacefully in a calm bedroom at dawnSleep

Deeper sleep

Your largest growth hormone pulse happens in deep sleep. A bedtime dose works with that rhythm.

Man in his 50s on a brisk morning walkEnergy

Steadier energy

Many people report steadier daytime energy and less of the afternoon crash.

Man in his 50s doing a light dumbbell row at the gymLean muscle

Lean muscle

Growth hormone helps preserve and build lean mass alongside training and protein.

Healthy home-cooked salmon and vegetable dinnerMetabolism

Fat metabolism

May support your body's use of stored fat, especially around the midsection.

Woman stretching after a home workoutRecovery

Faster recovery

Supports tissue repair, so you may bounce back faster from workouts.

Woman in her 50s applying moisturizer in the morningSkin

Skin

Growth hormone plays a role in collagen; some people notice firmer, more hydrated skin.

Sermorelin vs. HGH injections

Both raise growth hormone activity. They get there in very different ways.

SermorelinHGH (somatropin)
How it worksSignals your pituitary to release your own growth hormoneSupplies growth hormone directly
Natural feedbackPreserved: your body still regulates the releaseBypassed: output is set by the dose
Release patternNatural pulses, timed to sleepFixed by injection timing
AccessPrescribed online after a provider reviewTightly restricted; approved only for specific medical conditions
See If Sermorelin Is Right for You A licensed provider decides whether it is a fit.

What to expect, and when

Sermorelin is a gradual, long-term therapy. This is the typical arc people describe; your experience may differ.

  1. Weeks 1–4

    Sleep and energy

    Deeper, more restful sleep is often the first thing people notice, followed by better daytime energy.

  2. Months 2–3

    Recovery and skin

    Faster recovery after exercise; some notice changes in skin, hair and nails.

  3. Month 3+

    Body composition

    Shifts in lean muscle and fat, built up with consistent use alongside diet and training.

Results vary and are not guaranteed. Your provider can adjust your protocol as you go.

Bedside table at night with a reading lamp, book and glass of water At bedtime, on an empty stomach

A 30-second nightly routine

Sermorelin comes as a small subcutaneous injection, the same kind of short, thin needle used for insulin. It goes into the fatty tissue of the belly or thigh, and most people say they barely feel it.

Your provider sets your dose based on your age, weight and health history, and can adjust it over time.

How a typical dose works

  1. Skip food for 2 to 3 hours before bed. Food, especially carbs and fat, blunts the growth hormone response.
  2. Inject at bedtime, so the dose lines up with your natural deep-sleep pulse.
  3. Rotate sites between belly and thigh to keep the skin comfortable.

Simple, upfront pricing

Compounded sermorelin, 3 mg/mL, 5 mL vial. Choose 3 months at $149 a month, paid upfront, or a single month at $179.

Rx.com compounded sermorelin vial, 3 mg/mL
Best value

3 months

$149/month

Total $447 upfront

·

1 month

$179/month

Billed monthly

  • Provider review of your health intake
  • Personalized dosing
  • Compounded in the USA
  • Free shipping
  • No membership fee
  • No insurance needed
Get Started About $4.90 a day on the 3-month plan.

How it works

Licensed provider reviewing a patient's intake on a video call U.S.-licensed providers
1

Online health intake

A confidential questionnaire about your health, goals and medications. No appointment, no waiting room.

2

Provider review

A U.S.-licensed provider reviews your answers and prescribes sermorelin only if it is right for you.

3

Delivered to your door

Your prescription is compounded in the USA and shipped free, with ongoing access to your care team.

Start Your Online Visit

Important safety information

The most common side effects are injection-site redness, swelling or soreness, facial flushing, headache and nausea. Some people notice dizziness, restlessness or trouble sleeping. These are usually mild and tend to fade within the first week or two.

Sermorelin is not appropriate for people with active cancer or a recent cancer history, or during pregnancy or breastfeeding. Untreated hypothyroidism and diabetes need extra review, and some medications, including glucocorticoids (such as prednisone), can interfere with it. Share your complete health history and medication list during the intake. Get emergency care for trouble breathing or swelling of the face, tongue or throat.

Sermorelin FAQs

What is sermorelin?
Sermorelin is a lab-made version of the first 29 amino acids of growth hormone-releasing hormone (GHRH), the signal your hypothalamus uses to tell the pituitary gland to release growth hormone. Instead of supplying growth hormone directly, it prompts your body to make and release more of its own. It was FDA approved in 1997 under the brand name Geref; the manufacturer stopped making that product in 2008 for commercial reasons, and today sermorelin is prescribed as a compounded medication.
Is sermorelin a peptide?
Yes. Sermorelin is a 29-amino-acid peptide that matches the active part of growth hormone-releasing hormone (GHRH). At Rx.com it is a prescription medication prepared by a licensed U.S. compounding pharmacy after a provider review, not a supplement or a "research use only" peptide. Compounded medications are not FDA-approved.
Is sermorelin the same as HGH?
No. HGH (somatropin) is growth hormone itself, injected directly. Sermorelin works one step earlier: it stimulates your pituitary to release growth hormone in its natural pulses, and your body's own feedback system (somatostatin) still applies the brakes. That is why it is generally described as a gentler, more physiologic approach than injecting growth hormone. It is also not a steroid.
How do I take sermorelin?
Sermorelin is a small subcutaneous (under the skin) injection, usually taken once a day at bedtime. Your body releases its largest growth hormone pulse during deep sleep, so a nighttime dose works with that rhythm. Most protocols ask you to avoid eating for about 2 to 3 hours before your dose, because food (especially carbohydrates and fat) blunts the growth hormone response. Your provider sets your exact dose based on your age, weight and health history.
How much does sermorelin cost?
Rx.com sermorelin is $149 per month on the 3-month plan, paid upfront ($447), or $179 for a single month. There is no membership fee and no insurance is needed. You see your exact total before you pay.
How long does it take to notice anything?
Sermorelin is a gradual, long-term therapy, not a quick fix. People commonly report better sleep and energy within the first few weeks. Changes in skin, recovery and body composition, if they happen, usually take two to three months or more of consistent use. Results vary from person to person, and your provider can adjust your protocol along the way.
What are the side effects of sermorelin?
The most common side effects are injection-site redness, swelling or soreness, facial flushing, headache and nausea. Some people notice dizziness, restlessness or trouble falling asleep. These are usually mild and tend to settle within the first week or two. Rarely, allergic reactions can occur; get emergency care for trouble breathing or swelling of the face, tongue or throat.
Who should not take sermorelin?
Sermorelin is not appropriate for people with active cancer or a recent cancer history, during pregnancy or breastfeeding, or with known hypersensitivity to it. Untreated hypothyroidism and diabetes need extra review, and some medications (including glucocorticoids such as prednisone, and other growth hormone-related drugs) can interfere. Share your full health history and medication list during the online intake.
Do I need a prescription or lab work?
You need a prescription. You complete a short, confidential online health questionnaire and a U.S.-licensed provider reviews it. If sermorelin is right for you, the prescription is filled by a U.S. compounding pharmacy and shipped to your door. Your provider may ask for lab work in some cases.

Sermorelin Articles & Guides

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Browse all guides →

Ready to sleep deeper and recover faster?

Complete a 5-minute online intake and a U.S.-licensed provider will decide whether sermorelin is right for you.

Start Your Online Visit From $149/month · no membership fee · no insurance needed

Compounded medication: Sermorelin is available only with a prescription from a licensed provider after a health evaluation. Compounded medications are prepared by a licensed compounding pharmacy and are not FDA-approved products; the FDA has not evaluated them for safety, effectiveness or quality. Sermorelin is not intended to diagnose, treat, cure or prevent any disease. Individual results vary.

Medical services: All medical services, including clinical evaluations, treatment planning and prescribing decisions, are provided exclusively by licensed independent medical providers. Rx.com provides the technology platform and administrative coordination services, does not employ healthcare providers, and does not practice medicine. Rx.com does not manufacture compounded medications. This page is for informational purposes and is not a substitute for professional medical advice.

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