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Chlorhexidine Gluconate Bottle — prescription drug image

Chlorhexidine Gluconate

Chlorhexidine Gluconate 473ML of 0.12%

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What is Chlorhexidine Gluconate?

Periogard is indicated for the treatment of gingivitis. Chlorhexidine Topical is the generic version of Periogard. The average Periogard retail price is about $15 for a supply of 473 ml, 0.12% liquid. You can significantly reduce the Periogard price by using our free Singlecare coupon card at participating local pharmacies.

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What is Chlorhexidine Gluconate ?

Periogard is indicated for the treatment of gingivitis. Chlorhexidine Topical is the generic version of Periogard. The average Periogard retail price is about $15 for a supply of 473 ml, 0.12% liquid. You can significantly reduce the Periogard price by using our free Singlecare coupon card at participating local pharmacies.
  • Mild skin irritation
  • Tooth staining
  • Increased tartar build-up
  • Altered taste sensation
  • Mouth and throat irritation
  • Do not ingest. For external use only unless otherwise prescribed by a healthcare provider.
  • Avoid contact with eyes, ears, and mouth.
  • Stop use and ask a doctor if irritation, sensitization, or allergic reaction occurs.
  • Prolonged exposure may cause irritation or sensitization.
  • Not recommended for use on open skin wounds or as a preoperative skin preparation of the face or head.
What is chlorhexidine gluconate oral rinse used for?
The prescription 0.12% oral rinse (Peridex, PerioGard) is FDA-indicated for use between dental visits, as part of a professional dental program, to treat gingivitis, meaning gum redness, swelling, and bleeding on probing. It has not been shown to be effective for periodontitis and has not been tested in acute necrotizing ulcerative gingivitis (ANUG).
Does chlorhexidine mouthwash stain your teeth?
Yes, staining is a common side effect. Chlorhexidine gluconate oral rinse can stain teeth, tooth-colored fillings and restorations, and the tongue. It can also increase tartar buildup and change your sense of taste. A dental cleaning can usually remove the surface staining. Ask your dentist about how long to use it.
How long can you use chlorhexidine gluconate rinse?
The oral rinse is meant for use between dental visits as part of a professional program directed by your dentist, not indefinitely on your own. Because it can stain teeth, increase tartar, and alter taste, your dentist decides how long to continue it and will re-evaluate at follow-up visits. Follow the specific instructions you were given.
Is chlorhexidine gluconate available over the counter?
It depends on the form. The topical antiseptic skin cleansers, such as 2% and 4% Hibiclens, are available over the counter for skin prep and cleansing. The 0.12% oral rinse used for gingivitis (Peridex, PerioGard) is prescription-only and must be prescribed by your dentist or doctor. The two forms are not interchangeable.
What are the serious side effects of chlorhexidine gluconate?
The most serious concern is a rare but potentially life-threatening allergic (anaphylactic) reaction, which the FDA has warned can occur with both the oral rinse and topical antiseptic forms; do not use it if you are allergic to chlorhexidine. Get emergency care for signs like trouble breathing, swelling, or hives. More common oral-rinse effects include tooth and tongue staining, more tartar, and taste changes.
How much does Chlorhexidine Gluconate cost without insurance?
The price of Chlorhexidine Gluconate without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Chlorhexidine Gluconate?
Common side effects of Chlorhexidine Gluconate may include: Mild skin irritation, Tooth staining, Increased tartar build-up, Altered taste sensation, Mouth and throat irritation. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Chlorhexidine Gluconate?
Generic versions may be available for Chlorhexidine Gluconate. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Chlorhexidine Gluconate on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Chlorhexidine Gluconate?
The cheapest pharmacy for Chlorhexidine Gluconate depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Chlorhexidine Gluconate near you.

Chlorhexidine Gluconate Coupons & Prices

Chlorhexidine Gluconate 473ML of 0.12%

Prescriptions & Refills
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Chlorhexidine Gluconate Bottle — prescription drug image
Prescription
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Chlorhexidine Gluconate prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
118ml of 4% · Bottle 236 $19.99 $9.88
236ml of 4% · Bottle 236 $13.99 $8.15
237ml of 4% · Bottle 237 $22.49 $11.56
473ml of 4% · Bottle 473 $18.99 $10.62
532ml of 4% · Bottle 532 $93.14 $25.52
946ml of 4% · Bottle 946 $15.99 $12.58
3785ml of 4% · Bottle 3,785 $105.00
3790ml of 4% · Bottle 3,790 $60.69 $34.15

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a chlorhexidine gluconate coupon? Chlorhexidine gluconate is the generic antiseptic behind the prescription 0.12% oral rinse (sold as Peridex and PerioGard) that dentists prescribe for gingivitis, as well as the OTC topical skin cleansers like Hibiclens. Because it is already a low-cost generic, you usually do not need a manufacturer card to save. Cash prices still vary a lot from one pharmacy to the next, so comparing matters. Enter your ZIP above to see today's price near you, and Rx.com will compare discounts across more than 60,000 U.S. pharmacies at once.

What is chlorhexidine gluconate and how does it work?

Chlorhexidine gluconate is a bisbiguanide antiseptic that kills or slows the growth of bacteria. It comes in two very different types of product. The prescription 0.12% oral rinse (Peridex, PerioGard) is FDA-indicated for use between dental visits, as part of a professional program, to treat gingivitis, the gum redness, swelling, and bleeding on probing that your dentist checks for. It has not been shown to work for periodontitis and has not been tested in acute necrotizing ulcerative gingivitis (ANUG).

Separately, chlorhexidine gluconate topical solutions such as 2% and 4% Hibiclens (available over the counter) are antiseptic skin cleansers used for surgical skin prep, cleaning wounds and skin, and as a healthcare hand-wash. The two forms are not interchangeable, and the topical cleansers are not meant to be swallowed or used as a mouthwash.

Cost of chlorhexidine gluconate without insurance

Chlorhexidine gluconate is available as an FDA-approved generic, which is one reason it is generally an inexpensive medication. Even so, the cash price of the same bottle can differ widely from pharmacy to pharmacy in the same town, so it pays to compare rather than assume every counter charges the same. The topical antiseptic cleansers like Hibiclens are sold over the counter, while the 0.12% oral rinse requires a prescription from your dentist or doctor.

There is no manufacturer copay savings card for generic chlorhexidine gluconate. Instead of a card, use a discount price: enter your ZIP above to see today's price near you, and Rx.com compares discounted cash prices across more than 60,000 pharmacies so you can pick the lowest. A discount price is not insurance, and you use whichever is cheaper.

Related products and alternatives

Chlorhexidine gluconate is the generic ingredient, and the familiar prescription oral-rinse brands are Peridex and PerioGard. On the skin-antiseptic side, Hibiclens is the best-known OTC brand. You can compare the generic chlorhexidine against these brands to find the best price for the exact product and strength your dentist or doctor recommended.

Chlorhexidine treats gum inflammation locally and is not an oral antibiotic. If your dental provider is treating a gum or dental infection, they may separately prescribe an oral antibiotic such as clindamycin or doxycycline. These work differently and are not substitutes for one another, so always follow the specific product and instructions you were given.

Safety and side effects

The FDA has warned that rare but serious and potentially life-threatening allergic (anaphylactic) reactions can occur with chlorhexidine gluconate products, including both the oral rinse and the topical antiseptics. Do not use it if you have a known hypersensitivity to chlorhexidine. The oral rinse commonly stains teeth, tooth-colored fillings, and the tongue, can increase tartar (supragingival calculus) buildup, and may alter your sense of taste, with rare reports of a lasting taste change. It should not be used in people diagnosed with ANUG, and it contains alcohol (Peridex is about 11.6%).

With the topical cleansers, keep the product away from the eyes, ears, and the meninges. This is general information, not medical advice; use the exact product your dentist or doctor prescribed, follow the label, and talk with your provider or pharmacist about your history and any questions.

Sources & accuracy

This Chlorhexidine Gluconate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Chlorhexidine Gluconate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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0.12 · 1 solution
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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