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Dapsone Tablet — prescription drug image

Dapsone

Dapsone 100MG

Skin Care
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What is Dapsone?

Dapsone is used to treat certain skin conditions including, leprosy, acne, and dermatitis herpetiformis. Dapsone is a generic drug. The average Dapsone price is about $64 for a supply of 30 tablets, 25 mg tablets. You can use our Rx.com savings offer to get an average Dapsone discount of up to 80% off of the retail price at participating pharmacies near you.

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What is Dapsone ?

Dapsone is used to treat certain skin conditions including, leprosy, acne, and dermatitis herpetiformis. Dapsone is a generic drug. The average Dapsone price is about $64 for a supply of 30 tablets, 25 mg tablets. You can use our Rx.com savings offer to get an average Dapsone discount of up to 80% off of the retail price at participating pharmacies near you.
  • Trouble breathing, dark urine, fever, back pain, tiredness, yellow skin or eyes
  • Sudden and severe stomach pain, nausea, vomiting
  • Blue lips, fingernails, or mouth, unusual bleeding, bruising, or weakness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Tell your doctor if you are pregnant or breastfeeding, or if you have a glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • Talk to your doctor if you do not see some improvement within 12 weeks after you start this medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Trouble breathing, dark urine, fever, back pain, tiredness, yellow skin or eyes
What is dapsone used to treat?
Oral dapsone is FDA-approved to treat leprosy (Hansen's disease), usually in combination with other medicines, and dermatitis herpetiformis, an itchy blistering skin condition. Topical dapsone gel (Aczone) is FDA-approved to treat acne vulgaris; the 7.5% gel is approved for patients 9 years and older, while the 5% gel is approved for patients 12 years and older. Doctors also use oral dapsone off-label in some situations, such as helping prevent certain infections in people with a weakened immune system. Your prescriber can tell you why it was prescribed for you.
Is dapsone an antibiotic?
Dapsone is a sulfone medicine that has antibacterial activity, so in that sense it acts like an antibiotic against certain bacteria, including the one that causes leprosy. It also has anti-inflammatory effects, which is why it is used for inflammatory skin conditions such as dermatitis herpetiformis and, in gel form, acne. Whether it is being used as an antibacterial or an anti-inflammatory depends on the condition being treated.
Why do you need a G6PD test before taking dapsone?
Dapsone can cause red blood cells to break down (hemolysis), and this risk is much higher in people who have a G6PD enzyme deficiency. Providers usually check a G6PD blood test before starting oral dapsone so they know whether you are at higher risk and can monitor you appropriately. This is a decision your doctor makes based on your health history and lab results.
What are the most serious side effects of dapsone?
The most serious risks with oral dapsone include hemolytic anemia (especially with G6PD deficiency), methemoglobinemia (which can cause a bluish skin tint or a low pulse oximeter reading), and serious blood problems such as agranulocytosis, most often in the first months of treatment. Rare but potentially life-threatening reactions include severe skin reactions like Stevens-Johnson syndrome and a reaction called DRESS or Dapsone Hypersensitivity Syndrome with fever, rash, and liver involvement. Long-term use can also cause nerve or liver problems. Contact your provider right away if you notice unusual tiredness, bluish skin, fever, or a spreading rash.
Is there a generic version of Aczone (dapsone gel)?
Yes. Dapsone gel is available as a generic in the United States, so the generic is the same medicine as the brand Aczone at a lower cash price. Prices can still vary by pharmacy, so it is worth comparing. Enter your ZIP on Rx.com to see today's price near you.
How much does Dapsone cost without insurance?
The price of Dapsone without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 59% off retail prices with a free Rx.com coupon.
What are the common side effects of Dapsone?
Common side effects of Dapsone may include: Trouble breathing, dark urine, fever, back pain, tiredness, yellow skin or eyes, Sudden and severe stomach pain, nausea, vomiting, Blue lips, fingernails, or mouth, unusual bleeding, bruising, or weakness, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Dapsone?
Generic versions may be available for Dapsone. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Dapsone on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Dapsone?
The cheapest pharmacy for Dapsone depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Dapsone near you.

Dapsone Coupons & Prices

Dapsone 100MG

Skin Care
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Dapsone Tablet — prescription drug image
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Looking for a dapsone coupon? Dapsone is a sulfone medicine that is available as a low-cost generic in the United States, whether as oral tablets or as topical dapsone gel (the brand Aczone for acne). Because it is generic, the cash price is often affordable, but it can still vary widely from one pharmacy to the next, so comparing matters. Rx.com checks dapsone prices across more than 60,000 pharmacies so you can find the lowest price near you, no insurance required. Enter your ZIP above to see today's price and print or text yourself a free discount coupon.

What is dapsone and how does it work?

Dapsone is a sulfone medicine. It works by blocking folic acid production in bacteria and also has anti-inflammatory activity, in part by calming certain white blood cells called neutrophils. This combination is why it is used both as an antibacterial and as a treatment for several inflammatory skin conditions.

Oral dapsone is FDA-approved to treat leprosy (Hansen's disease), usually as part of combination therapy, and dermatitis herpetiformis (Duhring's disease), an itchy blistering skin condition. Topical dapsone gel (Aczone) is FDA-approved to treat acne vulgaris, and the approved age range depends on the strength: the 7.5% gel is approved for patients 9 years and older, while the 5% gel is approved for patients 12 years and older and is not recommended for children under 12. Doctors also prescribe oral dapsone off-label in certain situations, such as to help prevent Pneumocystis jirovecii pneumonia (PCP) and toxoplasmosis in people with a weakened immune system, and for a range of other neutrophilic and autoimmune skin diseases. Only your prescriber can decide whether dapsone is right for your condition.

How much does dapsone cost without insurance?

Dapsone is available as a generic in both its oral tablet and topical gel forms, which helps keep the cash price down. Even so, what you actually pay can differ a lot depending on which pharmacy you use and which form and strength you are prescribed, which is exactly why comparing prices matters. Two pharmacies in the same town can charge very different amounts for the same medicine.

Rx.com checks dapsone prices across more than 60,000 pharmacies and shows you a free discount coupon you can use whether or not you have insurance. There is no membership fee. Enter your ZIP code above to see today's price in your area and choose the pharmacy that costs the least. For the topical gel, the brand Aczone also has a manufacturer savings program; you can review the current terms on the official Aczone site, though eligibility and terms vary.

Dapsone alternatives and related medicines

If dapsone gel was prescribed for acne, generic dapsone is the same medicine as the brand Aczone at a lower cash price. Your prescriber may sometimes consider other treatments depending on your condition and how your skin or body responds.

  • For acne, topical clindamycin and tretinoin are commonly used alternatives, and oral minocycline is another option for some patients.
  • For preventing certain infections in people with a weakened immune system, trimethoprim-sulfamethoxazole is a widely used first-choice medicine.

Only your doctor can decide which treatment is right for you. You can compare cash prices for any of these on Rx.com by entering your ZIP.

Dapsone safety and side effects

Dapsone does not carry an FDA boxed warning, but oral dapsone does require careful medical supervision. It can cause dose-related breakdown of red blood cells (hemolysis and hemolytic anemia), especially in people with a G6PD enzyme deficiency, which is why providers usually check a G6PD test before starting oral therapy. It can also cause methemoglobinemia, which may show up as a bluish tint to the skin (cyanosis) or a low reading on a pulse oximeter. Serious blood problems such as agranulocytosis can occur, particularly in the first months of oral treatment, so your provider may order regular blood counts (CBC) to monitor you.

Rarely, dapsone can cause serious skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) and a reaction known as Dapsone Hypersensitivity Syndrome or DRESS, with fever, rash, liver involvement, and elevated eosinophils; these can be life-threatening. Long-term use may lead to nerve problems (peripheral neuropathy) or liver injury, and dapsone can increase sensitivity to sunlight. The topical gel is generally well tolerated, with mild local dryness or redness; using it together with benzoyl peroxide can cause a temporary yellow or orange discoloration of the skin that washes off. This information is for general education and is not medical advice. Tell your provider about all medicines you take, report symptoms like unusual tiredness, bluish skin, fever, or rash promptly, and follow their guidance on testing and dose.

Sources & accuracy

This Dapsone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Dapsone on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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