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Demeclocycline Hcl Tablet — prescription drug image

Demeclocycline Hcl

Demeclocycline HCl 300MG

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What is Demeclocycline Hcl?

Demeclocycline HCl, a tetracycline antibiotic, is used primarily to treat bacterial infections by inhibiting protein synthesis. Additionally, it's uniquely employed in the management of inappropriate secretion of antidiuretic hormone (SIADH) due to its ability to interfere with the hormone's action in the kidney.

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What is Demeclocycline Hcl ?

Demeclocycline HCl, a tetracycline antibiotic, is used primarily to treat bacterial infections by inhibiting protein synthesis. Additionally, it's uniquely employed in the management of inappropriate secretion of antidiuretic hormone (SIADH) due to its ability to interfere with the hormone's action in the kidney.
  • Fever, chills, cough, sore throat, and body aches.
  • Feeling unusually tired or weak, or unusually thirsty.
  • Difficulty breathing or swallowing.
  • Chest pain.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Sores near your anus.
  • Skin rash or redness.
  • Ringing in your ears.
  • Pain, redness, or swelling of your tongue.
  • Nausea, vomiting, or diarrhea that may contain blood.
  • Loss of appetite.
  • Lightheadedness or dizziness.
  • Increase in how much or how often you urinate.
  • Headache.
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Stay out of the sunlight while you are taking this medicine. This includes avoiding sunlight that comes in through a window. Also be aware that even when the sky is cloudy, the UV light can still reach your skin. If you must be in the sun, wear clothing that covers all of your skin. This includes sunglasses, a hat, and gloves. You can also apply sunscreen that has a SPF (sun protection factor) of greater than 15.
  • Your doctor may need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
  • You could get a serious sunburn while using this medicine. Carefully follow all instructions from your doctor.
  • Birth control pills may not work while you are using this medicine. To keep from getting pregnant, use another form of birth control. Other forms include condoms, a diaphragm, or contraceptive foam or jelly.
  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have kidney problems. Make sure your doctor knows if you have a history of diabetes insipidus (water diabetes), or if your skin or eyes are overly sensitive to sunlight. Make sure your doctor knows if you have syphilis.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
What is demeclocycline used for?
Demeclocycline is a tetracycline-class antibiotic used to treat bacterial infections caused by susceptible organisms. FDA-approved uses include rickettsial infections such as Rocky Mountain spotted fever and typhus, respiratory infections from Mycoplasma pneumoniae, several Chlamydia-related infections, relapsing fever, chancroid, certain skin and upper respiratory infections, and as an add-on for severe acne. Your doctor determines whether it is appropriate for your particular infection.
Is demeclocycline the same as doxycycline?
No. Demeclocycline and doxycycline are both antibiotics in the tetracycline class, but they are different medications with different dosing and characteristics. They are not interchangeable, and only your prescriber can decide which one is right for you.
How does demeclocycline treat SIADH and low sodium?
Beyond its approved antibiotic uses, demeclocycline is sometimes used off-label by physicians for low sodium (hyponatremia) related to SIADH because it can cause the kidneys to hold on to less water, which can help raise sodium levels. This is a decision only a doctor can make and manage, and this page does not recommend off-label use. Talk with your provider about whether it applies to you.
What foods and medications should you avoid while taking demeclocycline?
Dairy products, antacids, and supplements containing iron, calcium, or magnesium can reduce how well demeclocycline works, so your pharmacist may advise separating them from your dose. It can also make oral contraceptives less effective and may increase the effect of blood thinners. Avoid expired or discolored tetracyclines. Share your full medication and supplement list with your provider and pharmacist.
Is demeclocycline still available and does it come as a generic?
Yes, demeclocycline is available as a generic. The original brand, Declomycin, has been discontinued and is no longer marketed, so in the United States it is now dispensed as generic demeclocycline hydrochloride. Prices vary by pharmacy, so enter your ZIP above to see today's price near you.
How much does Demeclocycline Hcl cost without insurance?
The price of Demeclocycline Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Demeclocycline Hcl?
Common side effects of Demeclocycline Hcl may include: Fever, chills, cough, sore throat, and body aches., Feeling unusually tired or weak, or unusually thirsty., Difficulty breathing or swallowing., Chest pain., Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Demeclocycline Hcl?
Generic versions may be available for Demeclocycline Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Demeclocycline Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Demeclocycline Hcl?
The cheapest pharmacy for Demeclocycline Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Demeclocycline Hcl near you.

Demeclocycline Hcl Coupons & Prices

Demeclocycline HCl 300MG

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Demeclocycline Hcl Tablet — prescription drug image
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Demeclocycline Hcl 300mg (30)
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Looking for a demeclocycline HCl coupon? Demeclocycline hydrochloride is a generic tetracycline-class antibiotic, and because it is available as a generic it is often already low-cost, though the cash price can vary widely from one pharmacy to the next. Rx.com compares prices across more than 60,000 pharmacies so you can find a lower price near you, no insurance required. Enter your ZIP above to see today's price at pharmacies in your area.

What is demeclocycline and how does it work?

Demeclocycline hydrochloride is a broad-spectrum, bacteriostatic antibiotic in the tetracycline class. It works by slowing or stopping the growth of susceptible bacteria, which lets your immune system clear the infection. It was once sold under the brand name Declomycin, but that brand has been discontinued and is no longer marketed, so demeclocycline is now available in the United States only as a generic.

Doctors prescribe demeclocycline for a range of bacterial infections caused by organisms that are susceptible to it. FDA-approved uses include rickettsial infections (such as Rocky Mountain spotted fever, typhus, Q fever, and tick fevers), respiratory infections due to Mycoplasma pneumoniae, certain Chlamydia-related infections (including lymphogranuloma venereum, psittacosis, trachoma, inclusion conjunctivitis, and nongonococcal urethritis), relapsing fever, chancroid, upper respiratory infections due to Streptococcus pneumoniae, skin infections due to Staphylococcus aureus, and as an add-on treatment in severe acne. Your provider decides whether it is the right choice for your specific infection.

Demeclocycline cost without insurance

Because demeclocycline is a generic medication, it is generally more affordable than a brand-name drug, but the cash price is not the same everywhere. Two pharmacies on the same street can charge noticeably different amounts, which is exactly why comparing before you fill matters. You do not need insurance to use an Rx.com coupon; it is a cash-discount price you can show at the pharmacy counter.

Rx.com pulls live prices from more than 60,000 pharmacies so you can see what demeclocycline costs near you and pick the lowest option. Prices change over time and by location, so enter your ZIP above to see today's price rather than relying on a fixed figure.

Alternatives and related tetracycline antibiotics

Demeclocycline is one of several tetracycline-class antibiotics. Related options your doctor may consider include doxycycline, minocycline, and tetracycline. These are not interchangeable, and only your prescriber can decide which antibiotic fits your infection, your medical history, and any allergies.

Demeclocycline is also sometimes discussed alongside tolvaptan in the context of low sodium levels, because both can affect how the kidneys handle water. If you have been prescribed any of these, you can compare prices for each on Rx.com by entering your ZIP to find the best cash price near you.

Safety, side effects, and interactions

This is general information, not medical advice, so always follow your provider's and pharmacist's guidance. Demeclocycline does not carry an FDA boxed warning, but there are important cautions. Like other tetracyclines, it can cause permanent tooth discoloration and weakened enamel if used during tooth development, so it is generally avoided during the second half of pregnancy, in infants, and in children up to age 8 unless no other option works. It is contraindicated in pregnancy and in people allergic to tetracyclines. It can cause marked photosensitivity (severe sunburn), so limit sun exposure and use protection. Other possible effects include reversible increased urination (a drug-related nephrogenic diabetes insipidus), esophageal irritation, C. difficile-associated diarrhea, superinfection, and, rarely, increased pressure around the brain (pseudotumor cerebri). Use caution if you have kidney or liver problems.

Several everyday products can reduce how well demeclocycline works, including dairy, antacids, and supplements containing iron, calcium, or magnesium, so separate these from your dose as your pharmacist advises. Demeclocycline can also make oral contraceptives less effective and may strengthen the effect of blood thinners. Never use expired or discolored tetracyclines, as degraded product has been linked to a serious kidney syndrome. Tell your provider about all medicines and supplements you take.

Sources & accuracy

This Demeclocycline Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Demeclocycline Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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