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Dextromethorphan Polistirex Er Bottle — prescription drug image

Dextromethorphan Polistirex Er

Dextromethorphan Polistirex ER 89ML of 30MG/5ML

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What is Dextromethorphan Polistirex Er?

Dextromethorphan Polistirex ER is an extended-release cough suppressant that works by affecting the signals in the brain that trigger the cough reflex. It is commonly used to relieve coughs caused by the common cold or other respiratory ailments. This medication is typically provided in a liquid suspension form, maximizing its duration of effect to provide sustained relief.

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What is Dextromethorphan Polistirex Er ?

Dextromethorphan Polistirex ER is an extended-release cough suppressant that works by affecting the signals in the brain that trigger the cough reflex. It is commonly used to relieve coughs caused by the common cold or other respiratory ailments. This medication is typically provided in a liquid suspension form, maximizing its duration of effect to provide sustained relief.
  • Mild drowsiness, dizziness, nervousness, or restlessness
  • Nausea, vomiting, stomach pain
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have asthma or liver disease.
Is dextromethorphan polistirex the same as regular dextromethorphan (Delsym vs generic DM)?
It is the same active drug (dextromethorphan) but in a different form. Polistirex binds the medicine to a resin that releases it slowly, so it lasts up to 12 hours per dose. Regular dextromethorphan in ordinary syrups and lozenges is immediate-release and has to be taken more often. Delsym is the best-known brand of the polistirex 12-hour version, and FDA-approved store-brand generics of dextromethorphan polistirex work the same way.
How long does dextromethorphan polistirex last?
The extended-release polistirex formulation is designed to relieve cough for up to 12 hours from a single dose, which is why it is usually taken about twice a day. Always follow the dosing directions on the package for your age group.
Can you take dextromethorphan polistirex with other cold or allergy medicines?
Often yes, but check the labels first so you do not double up on the same ingredient (many multi-symptom cold products already contain dextromethorphan). The most important rule is to avoid it with an MAO inhibitor, or within 2 weeks of stopping one, and to use caution with other serotonergic drugs like SSRIs or SNRIs. When in doubt, ask a pharmacist before combining products.
Is dextromethorphan polistirex safe for children?
It is not for children under 4 years of age. For children 4 and older, use the pediatric product (such as Children's Delsym 12 Hour) and follow the age- and weight-based dosing on the label. Keep it out of reach of children and teens, and ask your child's doctor or pharmacist if you have any questions.
Does dextromethorphan polistirex make you drowsy or keep you awake?
Dextromethorphan is a cough suppressant, not a sedating antihistamine, so on its own it is not primarily a sleep aid and is not a stimulant. Some people notice mild drowsiness while others do not. If you are sensitive to it, avoid driving or operating machinery until you know how it affects you, and read the label of any combination product, since added ingredients can cause drowsiness.
How much does Dextromethorphan Polistirex Er cost without insurance?
The price of Dextromethorphan Polistirex Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Dextromethorphan Polistirex Er?
Common side effects of Dextromethorphan Polistirex Er may include: Mild drowsiness, dizziness, nervousness, or restlessness, Nausea, vomiting, stomach pain. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Dextromethorphan Polistirex Er?
Generic versions may be available for Dextromethorphan Polistirex Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Dextromethorphan Polistirex Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Dextromethorphan Polistirex Er?
The cheapest pharmacy for Dextromethorphan Polistirex Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Dextromethorphan Polistirex Er near you.

Dextromethorphan Polistirex Er Coupons & Prices

Dextromethorphan Polistirex ER 89ML of 30MG/5ML

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Dextromethorphan Polistirex Er 89ml of 30mg/5ml (1)
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Looking for a dextromethorphan polistirex ER coupon? Dextromethorphan polistirex is the long-acting cough suppressant sold over the counter as Delsym and its store-brand equivalents. This extended-release oral suspension uses an ion-exchange resin (polistirex) to release the medicine slowly, giving up to 12 hours of cough relief from a single dose. Even though it is available without a prescription, you can still enter your ZIP above to see today's price with an Rx.com coupon, which some shoppers find lower than the shelf price.

What is dextromethorphan polistirex ER and how does it work?

Dextromethorphan polistirex is an over-the-counter, extended-release oral suspension that temporarily relieves cough caused by minor throat and bronchial irritation, such as the kind that comes with a common cold or inhaled irritants. It works centrally, calming the cough reflex by acting on the cough center in the medulla of the brain. It does not treat the underlying cause of the cough; it simply quiets the urge to cough so you can rest.

The "polistirex" part is what makes this version last so long. The drug is bound to an ion-exchange resin that releases it gradually, which is why one dose can suppress cough for up to 12 hours. It is not intended for chronic cough from smoking, asthma, chronic bronchitis, or emphysema, or for cough that brings up a lot of phlegm, unless a doctor directs you to use it.

How to save on dextromethorphan polistirex with an Rx.com coupon

Because this is an over-the-counter product, you can buy it off the shelf without a prescription. But OTC does not always mean cheapest. Some cold and cough products cost less at the pharmacy counter with a discount coupon, or when your provider writes a prescription so the pharmacy rings it up as a covered item. It is worth comparing both.

Enter your ZIP code above to see today's price for dextromethorphan polistirex at pharmacies near you with a free Rx.com coupon. The store-brand generic (dextromethorphan polistirex) is FDA-approved and works the same as the name brand, so comparing the generic against the branded bottle is another easy way to save.

Alternatives and related cough and cold options

Dextromethorphan polistirex is one of several ways to manage a cough, and the right choice depends on the type of cough you have:

  • Dextromethorphan — the same active ingredient in immediate-release syrups and lozenges, dosed more often through the day.
  • Delsym — the leading brand name for dextromethorphan polistirex 12-hour suspension.
  • Guaifenesin — an expectorant that thins and loosens mucus rather than suppressing the cough reflex; useful for a chesty, productive cough.
  • Dextromethorphan-guaifenesin — a combination that both quiets a dry cough and loosens mucus.
  • Benzonatate — a prescription, non-narcotic cough medicine that works on the airways instead of the brain.

If you are unsure which fits your symptoms, ask a pharmacist or your provider. This is general information, not medical advice.

Safety, warnings, and interactions

Dextromethorphan polistirex is an OTC monograph product and carries no FDA boxed warning. Still, a few cautions matter. Do not use it while taking, or within 2 weeks of stopping, a monoamine oxidase inhibitor (MAOI) — combining the two can cause serious reactions, including serotonin syndrome. Use caution if you take other serotonergic medicines such as SSRIs or SNRIs, and ask a doctor before use if you have a chronic cough from smoking, asthma, chronic bronchitis, or emphysema, or a cough that brings up excessive phlegm.

Stop use and see a doctor if your cough lasts more than 7 days, goes away and comes back, or comes with fever, rash, or a persistent headache, because these can signal a more serious condition. High doses are sometimes misused recreationally for dissociative effects, so keep it out of the reach of children and teens. Do not give it to children under 4 years of age. This is not a substitute for your provider's or pharmacist's advice.

Sources & accuracy

This Dextromethorphan Polistirex Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Dextromethorphan Polistirex Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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