Donnatal Coupons & Prices

Looking for a Donnatal coupon? Donnatal is a brand-name prescription combination of belladonna alkaloids (hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide) plus phenobarbital, used as an add-on antispasmodic for certain digestive conditions. Because it can be costly at the pharmacy counter, Rx.com offers a free cash discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price at pharmacies near you.

What is Donnatal and how does it work?

Donnatal (and the extended-release form, Donnatal Extentabs) combines three belladonna alkaloids — hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide — with phenobarbital, a barbiturate. The belladonna alkaloids are anticholinergic/antispasmodic agents that relax smooth muscle in the gut, while phenobarbital adds mild sedation. It belongs to the class of gastrointestinal antispasmodic combinations.

Donnatal is an older product marketed under the FDA's Drug Efficacy Study Implementation (DESI) review; its labeling describes it as "possibly effective" as adjunctive (add-on) therapy for irritable bowel syndrome (also called irritable colon, spastic colon, or mucous colitis) and acute enterocolitis, and as adjunctive therapy in duodenal ulcer. Its effectiveness for these uses has not been conclusively established for any of these indications, so it is meant to support — not replace — your provider's main treatment plan. This is general information, not medical advice; talk with your prescriber about whether Donnatal is right for you.

Donnatal cost and savings: manufacturer card vs. Rx.com cash coupon

Two different tools can lower what you pay, and they work in different situations. The Donnatal brand runs an official savings program you can read about on the manufacturer's website, donnatal.com. Like most brand copay cards, it is generally limited to people with commercial (private) insurance, and its terms and eligibility can change — patients with Medicare, Medicaid, or other government coverage usually are not eligible.

The Rx.com cash coupon is different: it is a free discount you can use if you are uninsured, if you have Medicare or another plan the manufacturer card excludes, or if the copay card is declined at the register. You do not run it through insurance — you simply show the coupon and pay the cash price. Enter your ZIP above to compare today's price at pharmacies near you.

Another way to lower the cost is to ask about lower-cost equivalent belladonna-alkaloid and phenobarbital products, which are often sold for much less than brand-name Donnatal. Whether one of these is appropriate — and whether your pharmacist can substitute it — is a decision for your prescriber and pharmacist, and your Rx.com coupon can be used on many of them.

Alternative antispasmodics and lower-cost options

Donnatal is a DESI-era product and does not have an FDA-approved, therapeutically equivalent generic listed in the Orange Book. Other belladonna-alkaloid-with-phenobarbital products — sold under names such as phenobarbital-belladonna, Phenohytro, D-Tal, and Barbidonna — contain the same types of ingredients and are often less expensive, but they are also older unapproved products rather than substitutable generics. Because of that, your pharmacist may not be able to swap one automatically, so ask your prescriber and pharmacist which option is appropriate for you.

If you and your provider are weighing other GI antispasmodics, related medicines include dicyclomine (brand Bentyl), hyoscyamine (brand Levsin), and Librax (a chlordiazepoxide/clidinium combination). Unlike Donnatal, these do not contain phenobarbital. You can also look up phenobarbital on its own. Each has its own uses and cautions, so any switch should be made with your prescriber — and you can use an Rx.com coupon on most of them.

Safety, side effects, and who should not take it

Donnatal contains phenobarbital, a barbiturate that may be habit-forming. Phenobarbital itself is a controlled substance, but the Donnatal Tablets and Elixir formulations appear on the DEA's Table of Exempted Prescription Products, so in practice they are prescribed and dispensed as non-controlled legend (prescription) drugs. Common anticholinergic side effects include dry mouth, blurred vision, urinary retention, constipation, and a faster heartbeat. It can reduce your ability to sweat, raising the risk of overheating in hot weather, and it may impair your ability to drive or operate machinery. Phenobarbital can also make some other drugs less effective (for example, blood thinners) and can cause dependence and withdrawal.

Donnatal is contraindicated in people with glaucoma, obstructive disease of the urinary or gastrointestinal tract, paralytic ileus, severe ulcerative colitis or toxic megacolon, myasthenia gravis, or an unstable heart from acute bleeding. Avoid alcohol and other central-nervous-system depressants while taking it, and use extra caution in older adults. This is not a complete list — review your full history and medications with your provider or pharmacist before starting Donnatal.