Estradiol Valerate
Estradiol Valerate 5ML of 20MG/ML
What is Estradiol Valerate?
Estradiol Valerate is a synthetic estrogen used primarily in hormone replacement therapy (HRT) for menopausal symptoms and as part of feminizing hormone therapy for transgender women. It functions similarly to the endogenous estrogen estradiol but is administered as an ester derivative allowing for prolonged activity. Estradiol Valerate can be given orally, injected intramuscularly, or applied transdermally, promoting the development of female secondary sexual characteristics and regulating hormone levels.Side Effects
- Vaginal bleeding or spotting.
- Shortness of breath, cold sweat, and bluish-colored skin.
- Sudden or severe headache, problems with vision, speech, or walking.
Warnings
- It is unlikely that you will become pregnant while you are going through menopause. But, you should know that using this medicine while you are pregnant could harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away. If you have recently had an infant, tell your doctor if you are breast feeding.
- Make sure your doctor knows if you have asthma, epilepsy, migraine headaches, heart disease, or kidney disease. Also tell your doctor if you have endometriosis, gallbladder disease, liver disease, lupus, porphyria, or an underactive thyroid.
- This medicine should not be used to treat or prevent heart disease or stroke. In fact, hormone therapy can increase your risk of certain heart or blood vessel problems. Tell your doctor if you have a history of heart attack, stroke, high blood pressure, congestive heart failure, blood clots, or circulation problems.
- Your risk of heart disease or stroke from this medicine is higher if you smoke. Your risk is also increased if you have diabetes or high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. If you have diabetes, keep it under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level.
- This medicine may also increase your risk of other medical problems, including certain types of cancer. Talk with your doctor about how these risks might affect you.
Prescription savings · · · ·
What is Estradiol Valerate ?
Estradiol Valerate is a synthetic estrogen used primarily in hormone replacement therapy (HRT) for menopausal symptoms and as part of feminizing hormone therapy for transgender women. It functions similarly to the endogenous estrogen estradiol but is administered as an ester derivative allowing for prolonged activity. Estradiol Valerate can be given orally, injected intramuscularly, or applied transdermally, promoting the development of female secondary sexual characteristics and regulating hormone levels.- Vaginal bleeding or spotting.
- Shortness of breath, cold sweat, and bluish-colored skin.
- Sudden or severe headache, problems with vision, speech, or walking.
- Pain in your lower leg (calf).
- Swelling in your hands, ankles, or feet.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash.
- Breast changes or lumps.
- Chest pain, or coughing up blood.
- Dark-colored urine or pale stools, yellowing of your skin or the whites of your eyes.
- Nausea, vomiting, loss of appetite, pain in your upper stomach.
- Numbness or weakness in your arm or leg, or on one side of your body.
- It is unlikely that you will become pregnant while you are going through menopause. But, you should know that using this medicine while you are pregnant could harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away. If you have recently had an infant, tell your doctor if you are breast feeding.
- Make sure your doctor knows if you have asthma, epilepsy, migraine headaches, heart disease, or kidney disease. Also tell your doctor if you have endometriosis, gallbladder disease, liver disease, lupus, porphyria, or an underactive thyroid.
- This medicine should not be used to treat or prevent heart disease or stroke. In fact, hormone therapy can increase your risk of certain heart or blood vessel problems. Tell your doctor if you have a history of heart attack, stroke, high blood pressure, congestive heart failure, blood clots, or circulation problems.
- Your risk of heart disease or stroke from this medicine is higher if you smoke. Your risk is also increased if you have diabetes or high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. If you have diabetes, keep it under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level.
- This medicine may also increase your risk of other medical problems, including certain types of cancer. Talk with your doctor about how these risks might affect you.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests. This medicine may also affect the results of certain medical tests.
- Numbness or weakness in your arm or leg, or on one side of your body.
- Pain in your lower leg (calf).
- Shortness of breath, cold sweat, and bluish-colored skin.
- Sudden or severe headache, problems with vision, speech, or walking.
- Swelling in your hands, ankles, or feet.
- Vaginal bleeding or spotting.
Estradiol Valerate Coupons & Prices
Estradiol Valerate 5ML of 20MG/ML
4 ED medications in one dose
Sildenafil, tadalafil, vardenafil & apomorphine · Works in ~15 min · Lasts up to 36 hours
Looking for an estradiol valerate coupon? Estradiol valerate is the generic, long-acting injectable form of the estrogen sold under the brand name Delestrogen, given as an intramuscular shot to treat menopause symptoms and other conditions of low estrogen. As a generic it is already one of the lower-cost estrogen options, but the cash price can vary widely from one pharmacy to the next, so comparing before you fill matters. Rx.com checks prices across more than 60,000 pharmacies and gives you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you.
What is estradiol valerate and how does it work?
Estradiol valerate is a long-acting ester of estradiol, the main estrogen the body normally makes. It is given as an intramuscular injection (the brand name is Delestrogen), where it is slowly released and converted into active estradiol over days to weeks. This lets a single shot maintain estrogen levels for an extended period instead of taking a pill every day.
It is FDA-approved to treat moderate-to-severe hot flashes and night sweats of menopause, moderate-to-severe vaginal and vulvar dryness and irritation due to menopause, and low estrogen caused by hypogonadism, removal of the ovaries, or ovarian failure. It is also used in men as a palliative treatment for advanced prostate cancer that depends on androgens. Your provider decides the dose and how often you need an injection.
Cost of estradiol valerate without insurance
Because estradiol valerate is available as an FDA-approved generic, it is generally more affordable than many brand-name hormone products. There is no manufacturer copay savings card for the generic. What you actually pay at the counter can differ a lot between pharmacies in the same town, which is exactly why comparing prices is worth the effort.
Rx.com compares the cash price across more than 60,000 U.S. pharmacies and gives you a free discount coupon that anyone can use, with or without insurance. If you do have insurance, it can be worth checking the coupon price against your copay, since the discounted cash price is sometimes lower. Enter your ZIP above to see today's price and print or text yourself the coupon.
Estradiol valerate vs. other estrogen options
Estradiol valerate is one of several ways to take estrogen, and the right choice depends on your needs and what your provider recommends. Other common forms include:
- Estradiol - the oral tablet and other forms of the same base hormone.
- Estradiol cypionate - another long-acting injectable estradiol ester.
- Estradiol patch - a skin patch that delivers estradiol steadily through the skin.
- Premarin - conjugated estrogens, a brand-name estrogen product.
These are not interchangeable dose-for-dose, and switching forms should be done with your provider. Comparing prices on each version can help you and your prescriber weigh cost alongside what works best for you.
Safety and important warnings
Estrogens, including estradiol valerate, carry a boxed warning - the FDA's strongest label warning. Estrogen should not be used to prevent heart disease or dementia. In the Women's Health Initiative studies, estrogen taken together with a progestogen was linked to increased risks of heart attack, stroke, blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism), and invasive breast cancer. Estrogen used alone was linked to increased risks of stroke and deep vein thrombosis, along with a probable increase in dementia in women 65 and older. In a woman who still has her uterus, estrogen taken without a progestogen raises the risk of endometrial (uterine lining) cancer, so a progestogen is usually added.
Estradiol valerate should not be used if you have unexplained vaginal bleeding, known or suspected breast cancer or other estrogen-dependent cancer, a current or past blood clot, a history of stroke or heart attack, liver problems, or if you are pregnant. The general rule is the lowest effective dose for the shortest time needed, with regular check-ins. This is general information, not medical advice - talk with your provider about your personal risks and whether estradiol valerate is right for you.
This Estradiol Valerate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Estradiol Valerate on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Related Drugs
Browse more medications: starting with E · full A-Z directory · by condition · common drugs
Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.