Fluoxetine Hcl
Fluoxetine HCl (Prozac)
What is Fluoxetine Hcl?
Fluoxetine HCl (Prozac) is a prescription antidepressant used to treat depression, anxiety disorders, obsessive-compulsive disorder (OCD), panic disorder, bulimia nervosa, and other mental health conditions. As a selective serotonin reuptake inhibitor (SSRI), it helps improve mood, reduce anxiety, and restore emotional balance.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Changes in behavior, thoughts of hurting yourself or others
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bleeding problems, diabetes, glaucoma, or a history of seizures. Tell your doctor if you have had heart disease, a heart rhythm problem (including QT prolongation), heart attack, heart failure, low blood pressure, or a stroke.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsHeart rhythm problems, including QT prolongationSexual problems
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Prescription savings · · · ·
What is Fluoxetine Hcl ?
Fluoxetine HCl (Prozac) is a prescription antidepressant used to treat depression, anxiety disorders, obsessive-compulsive disorder (OCD), panic disorder, bulimia nervosa, and other mental health conditions. As a selective serotonin reuptake inhibitor (SSRI), it helps improve mood, reduce anxiety, and restore emotional balance.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Changes in behavior, thoughts of hurting yourself or others
- Confusion, weakness, muscle twitching
- Eye pain, vision changes, seeing halos around lights
- Fast, pounding, or uneven heartbeat, dizziness
- Unusual bleeding or bruising
- Unusual bleeding or bruising
- Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
- Trouble keeping still, feeling restless and agitated, racing thoughts, excessive energy, trouble sleeping
- Unusual bleeding or bruising
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bleeding problems, diabetes, glaucoma, or a history of seizures. Tell your doctor if you have had heart disease, a heart rhythm problem (including QT prolongation), heart attack, heart failure, low blood pressure, or a stroke.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsHeart rhythm problems, including QT prolongationSexual problems
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Skin rash, blisters, peeling, or redness
- Trouble breathing
- Unusual behavior, thoughts of hurting yourself or others
- Unusual bleeding or bruising
Fluoxetine Hcl Coupons & Prices
Fluoxetine HCl (Prozac)
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Looking for a fluoxetine HCl coupon? Fluoxetine hydrochloride is the low-cost generic version of Prozac, a widely prescribed SSRI antidepressant. Because it is a generic, it is already one of the more affordable antidepressants, but the cash price still varies a lot from one pharmacy to the next. Rx.com compares live prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see today's price and get a free discount coupon you can use at the pharmacy counter.
What is fluoxetine HCl and how does it work?
Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It is the active ingredient in the brand-name drugs Prozac and Sarafem, and it is available as a low-cost generic. SSRIs work by increasing the amount of serotonin available in the brain, a chemical messenger that helps regulate mood.
Fluoxetine is FDA-approved to treat major depressive disorder, obsessive-compulsive disorder (OCD), bulimia nervosa, panic disorder (with or without agoraphobia), and premenstrual dysphoric disorder (PMDD, marketed as Sarafem). In combination with olanzapine (sold as Symbyax and available as generic fluoxetine-olanzapine), it is approved for treatment-resistant depression and depressive episodes of bipolar I disorder. Your prescriber decides whether fluoxetine is right for your situation.
How much does fluoxetine cost without insurance?
Fluoxetine is available as a generic, which usually makes it far less expensive than the brand-name Prozac. Even so, generic prices are not the same everywhere. The cash price you pay without insurance can differ widely depending on which pharmacy you use, the strength, and the quantity, so it pays to compare before you fill.
Rx.com checks live prices at more than 60,000 pharmacies and shows you a free discount coupon that many people find beats their pharmacy's standard cash price. You can use an Rx.com coupon whether or not you have insurance. Enter your ZIP above to see today's price for fluoxetine in your area.
Fluoxetine alternatives and related SSRIs
Fluoxetine is one of several SSRIs used to treat depression, anxiety, and related conditions. If you and your prescriber are weighing options, other commonly prescribed SSRIs include sertraline, escitalopram, citalopram, and paroxetine. All are available as generics.
The brand-name equivalent of fluoxetine is Prozac. Because these medicines differ in how long they stay in the body, their side effects, and their drug interactions, only your prescriber can tell you which is the best fit. You can compare live prices on each of these on Rx.com to see which offers the best value at your pharmacy.
Fluoxetine safety and side effects
Fluoxetine carries a boxed warning for an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults under 24, especially early in treatment or after a dose change. Anyone starting fluoxetine should be watched closely for worsening mood or unusual changes in behavior. Common side effects include sexual dysfunction, trouble sleeping, decreased appetite, nausea, and headache. This is general information, not medical advice, so talk with your provider about what to expect.
Fluoxetine should not be used with or within 14 days of an MAOI, and combining it with other serotonin-raising drugs (such as triptans or other antidepressants) can raise the risk of serotonin syndrome. It can also increase the risk of abnormal bleeding when taken with NSAIDs, aspirin, or blood thinners, and it has been linked to low sodium (hyponatremia), QT prolongation, angle-closure glaucoma, activation of mania, and seizures. Its long half-life means it lingers in the body and can interact with other medicines for weeks. Do not stop fluoxetine suddenly; your prescriber will taper the dose gradually. Always share your full medication list with your prescriber and pharmacist.
This Fluoxetine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Fluoxetine Hcl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.