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Hydrocod Poli-Chlorphe Poli Er Bottle — prescription drug image

Hydrocod Poli-Chlorphe Poli Er

Hydrocod Poli-Chlorphe Poli ER 473ML of 10-8MG/5ML

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What is Hydrocod Poli-Chlorphe Poli Er?

If you suffer from a cough or cold symptoms, your doctor might prescribe hydrocodone polistirex/chlorpheniramine polistirex. The medication may cause drowsiness, so caution should be used when driving or operating machinery. Hydrocodone polistirex/chlorpheniramine polistirex can be habit forming and should only be taken under doctor supervision.

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What is Hydrocod Poli-Chlorphe Poli Er ?

If you suffer from a cough or cold symptoms, your doctor might prescribe hydrocodone polistirex/chlorpheniramine polistirex. The medication may cause drowsiness, so caution should be used when driving or operating machinery. Hydrocodone polistirex/chlorpheniramine polistirex can be habit forming and should only be taken under doctor supervision.
  • Changes in skin color, dark freckles
  • Severe constipation or stomach pain
  • Extreme dizziness or weakness, shallow breathing, slow heartbeat, seizures, cold, clammy skin
  • Lightheadedness, dizziness, fainting
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blue lips, fingernails, or skin, trouble breathing
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Call your doctor if your cough does not improve or if it gets worse within 5 days.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, Addison disease, an enlarged prostate or trouble urinating, glaucoma, heart disease, high blood pressure, asthma, pancreas problems, stomach or bowel problems, or thyroid problems. Tell your doctor if you have a history of head injury, seizures, or drug or alcohol addiction.
  • This medicine may cause the following problems:Respiratory depression (severe breathing problem)Increased risk of overdose, which can lead to deathIncreased risk of seizuresLow blood pressureAdrenal gland problems
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
Is hydrocodone-chlorpheniramine ER the same as Tussionex?
Yes. Hydrocodone polistirex / chlorpheniramine polistirex extended-release oral suspension is the generic version of the brand Tussionex Pennkinetic. They contain the same active ingredients in the same extended-release form. The brand Tussionex Pennkinetic has been discontinued, but the generic remains available.
What is hydrocodone polistirex and chlorpheniramine polistirex used for?
It is FDA-approved to relieve cough and upper respiratory symptoms associated with an allergy or a cold in adults 18 years of age and older. It is not indicated for anyone under 18. Hydrocodone is an opioid that suppresses the cough reflex, and chlorpheniramine is an antihistamine that helps with symptoms like runny nose and sneezing. The extended-release suspension provides up to 12 hours of relief per dose.
Is hydrocodone-chlorpheniramine a controlled substance?
Yes. Because it contains hydrocodone, an opioid, it is a Schedule II (C-II) controlled substance with a high potential for abuse. That means it is prescribed and dispensed under stricter federal rules than most medications, and it should always be stored securely and used exactly as directed.
How long does hydrocodone-chlorpheniramine ER suspension last?
The extended-release polistirex formulation releases the medicine slowly, so a single dose can provide up to 12 hours of relief. Always follow the exact dose and timing your prescriber gives you, and do not take more than directed.
Can children take hydrocodone-chlorpheniramine cough syrup?
No. This medicine is not indicated for anyone under 18 years of age. In January 2018 the FDA restricted all prescription hydrocodone-containing cough and cold medicines to adults 18 and older because the risks outweigh the benefits in children and teens, and it is contraindicated (must not be used) in children under 6 because of the risk of fatal breathing problems. Never give it to a child, and talk with a doctor about safe cough options for children.
How much does Hydrocod Poli-Chlorphe Poli Er cost without insurance?
The price of Hydrocod Poli-Chlorphe Poli Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Hydrocod Poli-Chlorphe Poli Er?
Common side effects of Hydrocod Poli-Chlorphe Poli Er may include: Changes in skin color, dark freckles, Severe constipation or stomach pain, Extreme dizziness or weakness, shallow breathing, slow heartbeat, seizures, cold, clammy skin, Lightheadedness, dizziness, fainting, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Hydrocod Poli-Chlorphe Poli Er?
Generic versions may be available for Hydrocod Poli-Chlorphe Poli Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Hydrocod Poli-Chlorphe Poli Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Hydrocod Poli-Chlorphe Poli Er?
The cheapest pharmacy for Hydrocod Poli-Chlorphe Poli Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Hydrocod Poli-Chlorphe Poli Er near you.

Hydrocod Poli-Chlorphe Poli Er Coupons & Prices

Hydrocod Poli-Chlorphe Poli ER 473ML of 10-8MG/5ML

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Hydrocod Poli-Chlorphe Poli Er Bottle — prescription drug image
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Looking for a hydrocodone-chlorpheniramine ER coupon? This extended-release oral suspension is the generic version of Tussionex Pennkinetic, a prescription cough medicine that combines the opioid antitussive hydrocodone with the antihistamine chlorpheniramine for up to 12 hours of relief. It is FDA-approved only for adults 18 years of age and older. The generic is widely available, but the cash price can vary a lot from one pharmacy to the next, so it pays to compare. Enter your ZIP above to see today's price at pharmacies near you. Rx.com compares prices across 60,000+ pharmacies so you can find the lowest cost without insurance on this Schedule II medication.

What is hydrocodone-chlorpheniramine ER suspension and how does it work?

Hydrocodone polistirex / chlorpheniramine polistirex extended-release oral suspension is a prescription combination cough medicine. It is the generic form of the discontinued brand Tussionex Pennkinetic. It pairs two active ingredients: hydrocodone, an opioid that quiets the cough reflex, and chlorpheniramine, a first-generation antihistamine that helps with the runny nose, sneezing, and other upper respiratory symptoms of an allergy or cold. Each 5 mL contains hydrocodone polistirex equal to 10 mg of hydrocodone bitartrate and chlorpheniramine polistirex equal to 8 mg of chlorpheniramine maleate.

The "extended-release" polistirex technology releases the medicine slowly, so a single dose can provide up to 12 hours of relief. It is FDA-approved to relieve cough and upper respiratory symptoms tied to an allergy or a cold in adults 18 years of age and older. It is not indicated for anyone under 18. In January 2018 the FDA restricted all prescription hydrocodone-containing cough medicines to adults because the risks in children and teens outweighed the benefits. It is for oral use only.

What does it cost without insurance, and can a coupon help?

Because a generic is available, hydrocodone-chlorpheniramine ER is generally an affordable medicine, but the cash price still varies widely from pharmacy to pharmacy, even in the same town. That is exactly why comparing matters. A discount price at one pharmacy can be very different from another, and the pharmacy with the best price is not always the one closest to you.

Rx.com compares prices across more than 60,000 pharmacies so you can spot the lowest cash price and bring a free coupon with you. There is no manufacturer savings card for this generic. To see what you would actually pay near you today, enter your ZIP above. Keep in mind this is a controlled substance, so your prescriber and pharmacy handle it under stricter rules than an everyday medication.

Related and alternative cough medicines

Hydrocodone-chlorpheniramine ER is the generic equivalent of the brand Tussionex Pennkinetic. Depending on your symptoms and your provider's judgment, other prescription cough treatments may be considered, such as promethazine-codeine or codeine-guaifenesin. For a non-opioid, non-narcotic cough option, benzonatate is sometimes prescribed. A related pain medicine that also contains hydrocodone is hydrocodone-acetaminophen, though it is used for pain, not cough.

Only your prescriber can decide which option is right for you. This information is not medical advice. If you want to compare prices on any of these, you can look each one up and check today's price at pharmacies near you.

Important safety information

This medicine carries FDA boxed warnings. As an opioid, it has a risk of addiction, abuse, and misuse that can lead to overdose and death, and it can cause life-threatening slowed breathing (respiratory depression). It is not indicated for anyone under 18 years of age, and it is contraindicated in children under 6 years of age because of the risk of fatal breathing problems. Using it together with benzodiazepines, alcohol, or other central nervous system depressants can cause deep sedation, slowed breathing, coma, and death. Prolonged use during pregnancy can cause withdrawal in the newborn, and it is best avoided in pregnancy. It can also interact with certain other drugs (CYP3A4 inhibitors and inducers).

It causes marked drowsiness, so do not drive or operate machinery until you know how it affects you. It contains a Schedule II opioid with high abuse potential, and accidental swallowing, especially by a child, can be fatal, so store it safely out of reach. This is a summary and not medical advice. Talk with your doctor or pharmacist about your health history and any other medicines you take before starting this medication.

Sources & accuracy

This Hydrocod Poli-Chlorphe Poli Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Hydrocod Poli-Chlorphe Poli Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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