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Lamotrigine Er Tablet Extended Release 24 Hour — prescription drug image

Lamotrigine Er

lamoTRIgine ER 100MG

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What is Lamotrigine Er?

Lamictal XR is used to treat persons suffering from seizures and bipolar disorder. Lamotrigine is the generic version. On average, Lamictal XR is priced at about $385 for a supply of 30 extended-release tablets. Luckily, you can use our Rx.com savings offer to receive a Lamictal XR discount of up to 80% off the retail price at participating pharmacies near you.

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What is Lamotrigine Er ?

Lamictal XR is used to treat persons suffering from seizures and bipolar disorder. Lamotrigine is the generic version. On average, Lamictal XR is priced at about $385 for a supply of 30 extended-release tablets. Luckily, you can use our Rx.com savings offer to receive a Lamictal XR discount of up to 80% off the retail price at participating pharmacies near you.
  • Painful sores in your mouth or around your eyes
  • Unusual bleeding, bruising, or weakness
  • Thoughts of hurting yourself, other unusual thoughts or behaviors
  • Fever, chills, cough, sore throat, body aches, swollen glands in your armpits, neck, or groin
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Blurred vision, double vision, or other vision problems
  • Feeling depressed, irritable, or restless
  • Stiff neck or back, headache, fever, nausea, vomiting
  • Yellow skin or eyes
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease (including heart attack, heart failure), heart rhythm problems, or a history of depression. Tell your doctor if you have had a rash or an allergic reaction to other seizure medicines.
  • This medicine may cause the following problems:Serious skin reactionHemophagocytic lymphohistiocytosis, a rare disorder which may be life-threateningDrug reaction with eosinophilia and systemic symptoms (DRESS), which may damage organs, including the liver, kidney, or heartIncreased risk of thoughts of suicide or other serious mood changesMeningitis (swelling of the membrane covering the brain and spinal cord)Eye or vision problems
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Unusual bleeding, bruising, or weakness
  • Yellow skin or eyes
What is lamotrigine ER (Lamictal XR) used for?
Lamotrigine ER is FDA-approved as add-on therapy for primary generalized tonic-clonic seizures and for partial-onset seizures (with or without secondary generalization) in people age 13 and older with epilepsy. It is also approved to help people age 13 and older with partial-onset seizures convert to lamotrigine as their only seizure medicine when they are already on one other antiepileptic drug. Unlike immediate-release lamotrigine, the XR form is not FDA-approved for bipolar disorder or Lennox-Gastaut syndrome.
What is the difference between lamotrigine and lamotrigine ER (extended-release)?
Both contain the same active drug, but immediate-release lamotrigine is usually taken more than once a day, while the extended-release (ER/XR) form releases the medicine slowly and is taken once daily. Their approved uses also differ: immediate-release lamotrigine is widely used for bipolar maintenance and other conditions, whereas the ER form is approved specifically for certain seizures in epilepsy and is not approved for bipolar disorder. Your prescriber decides which form is right for you.
What are the most serious side effects of lamotrigine ER, and what does the rash warning mean?
Lamotrigine ER has a boxed warning for serious, potentially life-threatening skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis. The risk is higher when the starting dose is too high, when the dose is raised too quickly, or when it is taken with valproate. Most rashes occur in the first 2 to 8 weeks but can happen later, so you should contact your provider and stop the drug at the first sign of a rash unless told otherwise. Other serious risks include multiorgan hypersensitivity (DRESS), HLH, blood cell disorders, aseptic meningitis, increased suicidal thoughts or behavior, and possible heart rhythm effects. Always follow your provider's guidance.
Is there a generic version of Lamictal XR, and how much does lamotrigine ER cost?
Yes, lamotrigine ER is the generic of Lamictal XR, which usually makes it much cheaper than the brand. Because it is a generic, prices are often already low, but cash prices still vary widely from pharmacy to pharmacy, so comparing before you fill can save money. Rx.com compares live prices across more than 60,000 pharmacies; enter your ZIP above to see today's price near you and get a free coupon.
Can you switch directly from immediate-release lamotrigine to lamotrigine ER?
Switching between immediate-release and extended-release lamotrigine involves specific dosing steps and monitoring, and it should only be done under your prescriber's direction. Do not change forms or doses on your own. Ask your doctor or pharmacist how any switch should be handled and what to watch for while your dose is adjusted.
How much does Lamotrigine Er cost without insurance?
The price of Lamotrigine Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Lamotrigine Er?
Common side effects of Lamotrigine Er may include: Painful sores in your mouth or around your eyes, Unusual bleeding, bruising, or weakness, Thoughts of hurting yourself, other unusual thoughts or behaviors, Fever, chills, cough, sore throat, body aches, swollen glands in your armpits, neck, or groin, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Lamotrigine Er?
Generic versions may be available for Lamotrigine Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Lamotrigine Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Lamotrigine Er?
The cheapest pharmacy for Lamotrigine Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Lamotrigine Er near you.

Lamotrigine Er Coupons & Prices

lamoTRIgine ER 100MG

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Lamotrigine Er Tablet Extended Release 24 Hour — prescription drug image
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Lamotrigine Er 100mg (30)
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Looking for a lamotrigine ER coupon? Lamotrigine extended-release (the generic of Lamictal XR) is an anticonvulsant taken once daily to help control certain seizures. Because a generic is available, it is usually already low-cost, but the cash price can vary a lot from one pharmacy to the next, so comparing before you fill matters. Rx.com checks prices across more than 60,000 pharmacies so you can find a low price near you. Enter your ZIP above to see today's price on lamotrigine ER.

What is lamotrigine ER and how does it work?

Lamotrigine extended-release (brand name Lamictal XR) is an antiepileptic drug in the phenyltriazine class. It works as a sodium channel blocker, helping to calm the overactive electrical signaling in the brain that can lead to seizures. The extended-release form is designed to be taken once a day, releasing the medicine slowly over time.

It is FDA-approved as add-on (adjunctive) therapy for primary generalized tonic-clonic seizures and for partial-onset seizures (with or without secondary generalization) in people age 13 and older with epilepsy. It is also approved to help people age 13 and older with partial-onset seizures convert to lamotrigine as their single medicine (monotherapy) when they are already taking one other antiepileptic drug. Note that, unlike immediate-release lamotrigine, the XR form is not FDA-approved for bipolar I disorder maintenance or for Lennox-Gastaut syndrome.

Cost of lamotrigine ER without insurance

Lamotrigine ER is available as a generic, which typically makes it much more affordable than the brand-name Lamictal XR. Even so, cash prices for the generic can differ widely between pharmacies in the same area, so it pays to compare rather than assume every counter charges the same amount. There is no manufacturer savings card for this generic.

Rx.com compares live cash prices across more than 60,000 pharmacies and gives you a free coupon you can show at the counter, with or without insurance. Enter your ZIP above to see today's price on lamotrigine ER at pharmacies near you and to pick up your coupon.

Alternatives and related medicines

Lamotrigine ER is one of several antiepileptic drugs. Which medicine is right depends on your seizure type, other conditions, and how you tolerate it, so any change should be discussed with your prescriber. Related options and forms include:

You can compare prices on each of these on Rx.com to see which fits your budget.

Safety and important warnings

Lamotrigine ER carries a boxed warning for serious, potentially life-threatening skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis. The risk is higher with a starting dose that is too high, dose increases that happen too fast, or use together with valproate. Most rashes appear in the first 2 to 8 weeks but can happen later. Contact your provider right away and stop the medicine at the first sign of a rash unless told otherwise.

Other serious risks reported include multiorgan hypersensitivity (DRESS), hemophagocytic lymphohistiocytosis (HLH), blood cell problems such as aplastic anemia and agranulocytosis, aseptic meningitis, an increased risk of suicidal thoughts or behavior (a class effect for antiepileptics), and dose-related effects on heart rhythm and conduction (extra caution is advised for people with structural or ischemic heart disease). Lamotrigine may also make hormonal birth control less effective, and drowsiness or dizziness can affect driving. This information is educational and is not medical advice; talk with your doctor or pharmacist about your own situation, dosing, and any side effects.

Sources & accuracy

This Lamotrigine Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Lamotrigine Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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