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Naftifine Hcl

Naftifine HCl

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What is Naftifine Hcl?

Naftin treats fungus infections. Naftifine Topical is the generic version. On average, Naftin is priced at about $451 for one tube, 45 grams of 2% topical cream. Luckily, you can use our Rx.com savings offer to receive a Naftin discount of up to 80% off the retail price at participating pharmacies near you.

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What is Naftifine Hcl ?

Naftin treats fungus infections. Naftifine Topical is the generic version. On average, Naftin is priced at about $451 for one tube, 45 grams of 2% topical cream. Luckily, you can use our Rx.com savings offer to receive a Naftin discount of up to 80% off the retail price at participating pharmacies near you.

  • Burning or stinging sensation
  • Redness, irritation, itching, or swelling of the skin
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have any infections or skin problems.
  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
  • Stop using this medicine and contact your doctor right away if you have a skin rash, itchiness, burning, stinging, swelling, or irritation after using this medicine.
What is naftifine HCl used to treat?

Naftifine HCl is a prescription topical antifungal used to treat dermatophyte (tinea) skin infections, including athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis). These are caused by fungi such as Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.

How long does it take for naftifine to work?

Naftifine is applied to the affected skin daily, and treatment courses with the 1% cream or gel typically run about 2 to 4 weeks. Use it for the full course your provider recommends, even if symptoms improve sooner. If your infection has not improved after completing the treatment, see your provider, since the diagnosis may need to be reevaluated.

Is naftifine the same as Naftin?

Yes. Naftifine hydrochloride is the generic name for the active ingredient, and Naftin is the brand name. Naftifine is the lower-cost generic version of Naftin.

Can you buy naftifine over the counter or do you need a prescription?

Naftifine (Naftin) is a prescription topical antifungal, so you need a prescription from your provider to get it. Some other topical antifungals, such as clotrimazole and terbinafine, are available over the counter, but naftifine itself is prescription-only.

What are the side effects of naftifine cream?

The most common side effects are local and usually mild, including burning or stinging, itching, dryness, and redness at the application site. Stop using it and contact your provider if you develop irritation or signs of an allergic skin reaction. Naftifine is for external use only and should be kept away from the eyes, nose, mouth, and other mucous membranes.

How much does Naftifine HCl 45GM of 2% cost without insurance?
The price of Naftifine HCl 45GM of 2% without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Naftifine HCl 45GM of 2%?
Common side effects of Naftifine HCl 45GM of 2% may include: Burning or stinging sensation, Redness, irritation, itching, or swelling of the skin, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Naftifine HCl 45GM of 2%?
Generic versions may be available for Naftifine HCl 45GM of 2%. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Naftifine HCl 45GM of 2% on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Naftifine HCl 45GM of 2%?
The cheapest pharmacy for Naftifine HCl 45GM of 2% depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Naftifine HCl 45GM of 2% near you.

Naftifine Hcl Coupons & Prices

Naftifine HCl

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Naftifine Hcl Tube — prescription drug image
Prescription
Naftifine Hcl 45gm of 2% (6)
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$146/mo vs. brand-name GLP-1 medications $1,300+/mo Save up to 88%
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a naftifine HCl coupon? Naftifine hydrochloride is the low-cost generic version of the prescription topical antifungal Naftin, used to treat athlete's foot, jock itch, and ringworm. Because pharmacy cash prices for the same tube can vary widely, comparing before you fill matters. Enter your ZIP above to see today's price at pharmacies near you, and Rx.com compares prices across more than 60,000 pharmacies to help you find the lowest cost.

What is naftifine HCl and how does it work?

Naftifine hydrochloride is a prescription topical allylamine antifungal, sold under the brand name Naftin. It treats tinea (dermatophyte) skin infections, including interdigital athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis). These infections are caused by dermatophyte fungi such as Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.

It works by inhibiting an enzyme called squalene epoxidase, which blocks the fungus from making ergosterol, a key part of its cell membrane. The 1% cream is applied once daily (some labeling allows twice daily), and the 2% gel or cream is applied once daily. Courses with the 1% cream or gel typically run about 2 to 4 weeks.

Naftifine HCl cost without insurance and how to save

As a generic, naftifine HCl is already lower-cost than the brand, but cash prices still differ from pharmacy to pharmacy, so it pays to compare. Rx.com checks prices across more than 60,000 pharmacies so you can find the lowest cost near you. Enter your ZIP above to see today's price and print or show a free coupon at the pharmacy counter, whether or not you have insurance.

The brand-name version, Naftin, offers a manufacturer co-pay assistance program. You can check current eligibility and terms, which vary, on the official page at naftin.com. Manufacturer savings programs generally apply to the brand product rather than the generic.

Naftifine alternatives and how it compares

Naftifine is one of several topical antifungals used for dermatophyte skin infections. Its brand equivalent is Naftin. Other commonly prescribed or available topical antifungals include:

These products differ in their active ingredient, dosing, and how they are prescribed or sold. Your prescriber or pharmacist can help you choose the right option for your infection. Enter your ZIP above to compare prices on naftifine and its alternatives.

Safety and side effects

Naftifine HCl is for topical (external) use only. It is not for use in the eyes, mouth, or vagina, and it is not for oral or intravaginal use. Avoid contact with the eyes, nose, mouth, and other mucous membranes. Stop using it and contact your provider if you develop irritation or signs of an allergic skin reaction (allergic contact dermatitis). Naftifine has no boxed warning.

The most common side effects are local and usually mild: burning or stinging, itching, dryness, and redness at the application site. If your infection does not improve after the full treatment course, see your provider, since the diagnosis may need to be reevaluated. This information is not medical advice; talk with your doctor or pharmacist about your specific situation.

Sources & accuracy

This Naftifine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Naftifine Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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