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Natazia Disp Pack   — prescription drug image

Natazia

Natazia

Prescriptions & Refills
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What is Natazia?

Natazia is a prescription birth control pill used to help prevent pregnancy and treat heavy menstrual bleeding in certain women. Compare Natazia cost, find a Natazia coupon, and save on your prescription with the free Rx.com Prescription Discount Card.

Prescription savings · · · ·

What is Natazia ?

Natazia is a prescription birth control pill used to help prevent pregnancy and treat heavy menstrual bleeding in certain women. Compare Natazia cost, find a Natazia coupon, and save on your prescription with the free Rx.com Prescription Discount Card.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, or coughing up blood
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Double vision or other trouble seeing
  • New or unusual headaches
  • Unusual or unexpected vaginal bleeding or heavy bleeding
  • Pain in your lower leg (calf)
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • You may need to stop using this medicine for a few weeks before and after you have surgery because of the risk of blood clots.
  • This medicine may make your periods lighter or shorter, and you might not have a period in some cycles. However, tell your doctor if you miss 2 periods in a row, or if you miss 1 period and did not take the pills on schedule during the month. You might be pregnant.
  • This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clotsPossible risk of breast or cervical cancerLiver cancers or tumorsHigh blood pressureGallbladder disease
  • Tell your doctor if you have cancer, diabetes, blood circulation problems, or migraine headaches, or if you smoke. Tell your doctor if you are breastfeeding, or if you have recently given birth. Also tell your doctor if you have kidney disease, high blood pressure, gallbladder disease, high cholesterol, or a history of depression, angioedema, or jaundice.
  • Tell your doctor right away if you think you are pregnant or if you miss your period 2 months in a row, because you could be pregnant.
What is Natazia used for?
Natazia is FDA-approved to prevent pregnancy in women who choose an oral contraceptive for birth control. It is also approved to treat heavy menstrual bleeding that is not caused by a diagnosed uterine condition, in women who also want the Pill for contraception. It is the first oral contraceptive FDA-approved for heavy menstrual bleeding.
Is Natazia a good birth control pill?
Natazia is an FDA-approved combination pill that both prevents pregnancy and can reduce heavy menstrual bleeding, which makes it a useful option for some women. Whether it is a good fit for you depends on your health history, whether you smoke, your age, and other factors. Its efficacy has not been evaluated in women with a BMI greater than 30. Ask your prescriber whether it is right for you.
Is there a generic for Natazia?
No. As of now there is no FDA-approved generic version of Natazia, so you are paying for the brand-name pill. Because of that, comparing prices matters. Enter your ZIP above to see today's cash price with an Rx.com coupon, and check the manufacturer savings card terms at natazia.com if you have commercial insurance.
How does Natazia treat heavy menstrual bleeding?
Natazia's combination of estrogen (estradiol valerate) and progestin (dienogest) helps stabilize and thin the lining of the uterus, which reduces the amount of blood lost during menstruation over time. It is approved for heavy menstrual bleeding that is not caused by a diagnosed uterine condition, in women who also choose the Pill for birth control.
Can Natazia cause blood clots?
Yes. Like other combination birth control pills, Natazia can increase the risk of venous and arterial blood clots, and that risk is higher when additional risk factors are present. Its boxed warning states that women over 35 who smoke should not use it because of the increased risk of serious cardiovascular events. Talk with your doctor about your personal risk, and seek care immediately for symptoms like sudden leg pain, chest pain, or shortness of breath.
How much does Natazia 28 Tablets cost without insurance?
The price of Natazia 28 Tablets without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 31% off retail prices with a free Rx.com coupon.
What are the common side effects of Natazia 28 Tablets?
Common side effects of Natazia 28 Tablets may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Chest pain, trouble breathing, or coughing up blood, Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes, Double vision or other trouble seeing, New or unusual headaches. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Natazia 28 Tablets?
Generic versions may be available for Natazia 28 Tablets. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Natazia 28 Tablets on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Natazia 28 Tablets?
The cheapest pharmacy for Natazia 28 Tablets depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Natazia 28 Tablets near you.

Natazia Coupons & Prices

Natazia

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Natazia Disp Pack   — prescription drug image
Prescription
Natazia 1 package (28 tablets), 3mg /2-2mg/2-3mg/1mg (5)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a Natazia coupon? Natazia is a brand-name combination birth control pill (estradiol valerate and dienogest) with no generic version yet available, so cash prices can run high. Rx.com offers a free cash coupon you can use at the pharmacy counter whether or not you have insurance. Enter your ZIP above to see today's price at pharmacies near you, then bring the coupon to save on your prescription.

What is Natazia and how does it work?

Natazia is a combination oral contraceptive that pairs two hormones, estradiol valerate (a form of estrogen) and dienogest (a progestin). Unlike most birth control pills, it is a four-phasic (quadriphasic) pill, meaning the hormone doses change across four stages of the cycle. It is FDA-approved to prevent pregnancy in women who choose an oral contraceptive for birth control, and it is also the first oral contraceptive FDA-approved to treat heavy menstrual bleeding that is not caused by a diagnosed uterine condition, in women who also want the Pill for contraception.

For heavy menstrual bleeding, the steady combination of estrogen and progestin helps stabilize and thin the uterine lining, which reduces the amount of menstrual blood loss over time. Its efficacy has not been studied in women with a BMI greater than 30 kg/m2. Natazia does not protect against HIV or other sexually transmitted infections.

Natazia manufacturer savings card vs. Rx.com cash coupon

The maker of Natazia offers a manufacturer savings card, and you can review its current terms on the official site at natazia.com. Manufacturer copay cards like this are generally limited to people with commercial (private) insurance and typically exclude anyone covered by Medicare, Medicaid, or other government programs. Terms, eligibility, and any dollar limits vary and change over time, so check the official page for the latest details.

The Rx.com cash coupon works differently: it is a cash-price discount, so it can help if you are uninsured, are on Medicare or another government plan that the manufacturer card excludes, or if the savings card is declined at the counter. You cannot combine a cash coupon with insurance on the same fill, but you can compare both and use whichever is lower. Because there is no generic for Natazia yet, the brand price is what you are comparing. Enter your ZIP above to see today's Rx.com price near you.

Natazia alternatives and related birth control pills

Natazia is one of several combination birth control pills, and the right choice depends on your health history and what your prescriber recommends. Other combination pills people compare with Natazia include Yaz, Yasmin, Beyaz, Loryna, and Lo Loestrin Fe. If you cannot take estrogen, a progestin-only option such as Slynd may be discussed with your provider.

Several of these alternatives have lower-cost generic versions available, which can be a significant savings lever compared with a brand-only pill like Natazia. Only your prescriber can decide whether switching is appropriate for you, so use this list as a starting point for that conversation rather than a recommendation to change on your own.

Natazia safety and warnings

Natazia carries a boxed warning: women older than 35 who smoke should not use it, because smoking combined with estrogen-containing birth control pills significantly raises the risk of serious cardiovascular events such as heart attack, stroke, and blood clots. Like other combination pills, Natazia can increase the risk of venous and arterial blood clots, and that risk is higher when other risk factors are present.

Other risks include liver disease or liver tumors, high blood pressure, gallbladder disease, and changes in how your body handles blood sugar and fats. Natazia should not be used during pregnancy. This information is a summary, not medical advice, and does not cover every risk. Talk with your doctor or pharmacist about your personal health history and report any concerning symptoms right away.

Sources & accuracy

This Natazia information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Natazia on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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